Tourette Syndrome; Neurosciences; Obsessive-Compulsive Disorder; Physics; Psychiatry and Psychology
I am interested in the development and application of new functional brain imaging paradigms. These include resting state functional connectivity analyses and neurofeedback via real-time fMRI (rt-fMRI). Rt-fMRI neurofeedback has great potential as a clinical treatment for mental and neurological disorders. When used in conjunction with resting state functional connectivity assessments (collected before and after the neurofeedback), it provides a powerful perturb-and-measure approach for studying human brain function.
Extensive Research Description
1. Using neurofeedback of real-time fMRI data to train patients with tic disorders to control activity in the supplementary motor area, which we hope will translate into a reduction of their urges to tic.
2. Using neurofeedback of real-time fMRI data to train patients with obsessive-compulsive disorder to control activity in a region of their orbitofrontal cortex associated with contamination anxiety, and examining how this training affects their symptoms.
3. Evaluating changes in resting state functional connectivity between brain areas before and after neurofeedback to gain an understanding of how the neurofeedback alters brain networks.
4. Examining the correlates of excessive video game playing in adolescents. We are comparing gamers and non-gamers in terms of both their brain function (assessed using resting state functional connectivity measures) and their behavior.
- Scheinost, D., Stoica, T., Saksa, J., Papademetris, X., Constable, R.T., Pittenger, C., Hampson, M. 2013. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry, 3, e25
- Hampson, M., Driesen, N.R., Skudlarski, P., Gore, J.C., Constable, R.T. 2006. Brain connectivity related to working memory performance. The Journal of Neuroscience, 26(51): 13338-13343.
- Hampson, M., Stoica, T., Saksa, J., Scheinost, D., Qiu, M., Bhawnani, J., Pittenger, C., Papademetris, X. 2011, Constable, R.T. 2011. Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety, Journal of Visualized Experiment
- Hampson, M., Scheinost, D., Qiu, M., Bhawnani, J., Lacadie, C., Leckman, J.F., Constable, R.T., Papademetris, X. 2011. Biofeedback from the supplementary motor area reduces functional connectivity to subcortical regions. Brain Connectivity, 1(1): 91-8.
- Hampson, M., Tokoglu, F., King, R.A., Constable, R.T., Leckman, J.F. 2009. Brain areas co-activating with motor cortex during chronic motor tics and intentional movements. Biological Psychiatry, 65(7): 594-9.
- Hoffman, R.E., Anderson, A.W., Varanko, M., Gore, J.C., Coric, V., Hampson, M. 2008. Time course of regional brain activation associated with onset of auditory/verbal hallucinations. British Journal of Psychiatry,193: 424-425.
- Hampson, M., Tokoglu, F., Sun, Z. Schafer, R., Skudlarski, P., Gore, J.C., Constable, R.T., 2006. Connectivity-behaviour analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. NeuroImage, 31: 513-519.