We are concentrating on the 5 organ systems, innovolved by hereditary hemorrhagic telangiectasia. See www.hhtavm.org
We are actively researching exercise stress testing in the follow-up of patients with pulmonary arteriovenous malformations.
Extensive Research Description
Dr. Robert I. White Jr.'s research interests include clinical investigation of the new diagnostic and therapeutic methods for treating vascular malformations. Among patients with congenital vascular malformations, there exists an uncommon autosomal dominant type referred to as Osler-Weber-Rendu Syndrome or more properly Hereditary Hemorrhagic Telangiectasia (HHT). The clinical manifestations of this disorder are due to direct artery-to-vein connections referred to as arteriovenous malformation which occur in nose, brain, lung and boweland to lead to abnormal bleeding and other physiological consequences. Dr. White's group is concluding a number of ongoing collaborative projects with the gastrointestinal and pulmonary sections of medicine, and the Department of Neurology, Neurosurgery and Otolaryngology.We are embarking on a new area of study: reproduciability and efficacy of exercise oximetry in assessing children and adults with pulmonary arteriovenous malformations. Our first paper appeared in Pediatric Cariology 2009. online version available in pub med.
Distal Cross-sectional Occlusion Is the “Key” to Treating Pulmonary Arteriovenous Malformations.
Jeffrey S. Pollak, MD, Robert I. WhiteJr, MD. Journal of Vascular and Interventional Radiology, Vol 23, Issue 12, December 2012, Pages 1578–1580.
Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: gene-phenotype correlations.
Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: gene-phenotype correlations. Nishida T, Faughnan ME, Krings T, Chakinala M, Gossage JR, Young WL, Kim H, Pourmohamad T, Henderson KJ, Schrum SD, James M, Quinnine N, Bharatha A, Terbrugge KG, White RI Jr. Am J Med Genet A. 2012 Nov;158A(11):2829-34. doi: 10.1002/ajmg.a.35622. Epub 2012 Sep 18. 22991266
The Young's procedure for severe epistaxis from hereditary hemorrhagic telangiectasia.
Richer SL, Geisthoff UW, Livada N, Ward PD, Johnson L, Mainka A, Henderson KJ, Maune S, White RI Jr, Ross DA. Am J Rhinol Allergy. 2012 Sep-Oct;26(5):401-4. doi: 10.2500/ajra.2012.26.3809.
Reproducibility of oxygen saturation monitoring during six-minute walk test and exercise stress test in patients with pulmonary arteriovenous malformations associated with hereditary hemorrhagic telangiectasia.
Li W, Niu B, Henderson K, Northrup V, Pollak JS, Trow T, Fahey J, White RI Jr. Pediatr Cardiol. 2011 Jun;32(5):590-4. doi: 10.1007/s00246-011-9917-8. Epub 2011 Feb 19.
International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia.
Faughnan ME, Palda VA, Garcia-Tsao G, Geisthoff UW, McDonald J, Proctor DD, Spears J, Brown DH, Buscarini E, Chesnutt MS, Cottin V, Ganguly A, Gossage JR, Guttmacher AE, Hyland RH, Kennedy SJ, Korzenik J, Mager JJ, Ozanne AP, Piccirillo JF, Picus D, Plauchu H, Porteous ME, Pyeritz RE, Ross DA, Sabba C, Swanson K, Terry P, Wallace MC, Westermann CJ, White RI, Young LH, Zarrabeitia R; HHT Foundation International - Guidelines Working Group. J Med Genet. 2011 Feb;48(2):73-87. doi: 10.1136/jmg.2009.069013. Epub 2009 Jun 23.
Hemothorax due to rupture of pulmonary arteriovenous malformation: an interventional emergency.
Hemothorax due to rupture of pulmonary arteriovenous malformation: an interventional emergency. Berg AM, Amirbekian S, Mojibian H, Trow TK, Smith SJ, White RI Jr. Chest. 2010 Mar;137(3):705-7. PubMed PMID: 20202952.
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome.
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome. Gallione C, Aylsworth AS, Beis J, Berk T, Bernhardt B, Clark RD, Clericuzio C, Danesino C, Drautz J, Fahl J, Fan Z, Faughnan ME, Ganguly A, Garvie J, Henderson K, Kini
Treatment guidelines for hereditary hemorrhagic telangiectasia.
2009 Treatment guidelines for hereditary hemorrhagic telangiectasia. Trerotola SO, Pyeritz RE, White RI Jr, Picus D, Miller FJ; HHT Foundation; HHT Centers. J Vasc Interv Radiol. 2010 Feb;21(2):179. Epub 2009 Dec 21. PubMed PMID: 20022766.