The Department of Dermatology at Yale, one of the oldest in the country, is deeply rooted in research. The clinical research efforts of Yale dermatologists contributed significantly to the treatment of lethal skin tumors such as melanomas and cutaneous T-cell lymphomas. At present, we are actively exploring the uses of new technology such as photopheresis, a therapy for life-threatening and debilitating diseases like cutaneous T-cell lymphoma and graft versus host disease. A large portion of the department's research is performed through two separate research entities: The Yale SPORE in Skin Cancer Center and the Spitzoid Neoplasm Repository.
The Spitzoid Neoplasm Repository is an invaluable resource for researchers looking for specific markers and/or genetic abnormalities in neoplastic cells. The Repository facilitates all angles of research, including immunohistochemical, molecular, genetic and other studies.
The overall goals of the Yale SPORE in Skin Cancer (YSPORE) are to improve prevention, diagnosis and treatment of melanomas. One of the overriding themes of the YSPORE is to reveal biomarkers and targets for therapy based on information from Next-Generation (Next-Gen) DNA sequencing, genomics and proteomics analyses....
Our department works closely with other basic immunologists and molecular biologists at Yale exploring topics including:
- The role of dendritic epidermal T-cells in cutaneous immunity and immunopathology
- Identification and characterization of tumor (cutaneous T-cell lymphoma) specific class I major histocompatibility complex (MHC) associated peptide antigens
- The basis of normal and abnormal Tcell homing to the skin
In pigment cell projects, focusing on:
- Growth regulation of normal and malignant melanocytes
- Genetic defects in albinism and piebaldism
In the field of keratinocyte biology, we offer training in:
- Modulation and measurement of keratinocyte growth in vivo and in vitro
- Analytic techniques used to study the biochemistry of epidermal differentiation
There are 7,432 sq. feet of research space in the department. The laboratories are located on the fifth floor of LCI and the sixth floor of the Hunter Building. Facilities are available for:
- Tissue culture
- Transmission electron microscopy
- Flow cytometry
- Animal studies
- Digital imaging
- Molecular biology, including RNA and DNA isolation from tissue, PCR amplification and analysis of samples, transgene construction and plasmid preparation