Viswanathan Muthusamy

Associate Research Scientist in Dermatology

Research Interests

melanoma; metastasis

Extensive Research Description

My primary interest lies in understanding the molecular and epigenetic alterations that drive tumor formation and metastasis in melanoma and other skin cancers. My current research is focused on: i) conditional knock out of genes involved in establishing epigenetic patterns and its effects on melanoma formation, metastasis and establishment of tumor heterogeneity ii) development of epigenetics based molecular markers for early diagnosis and improved prognostication of melanoma.

Selected Publications

  • Muthusamy V, Bosenberg M, Wajapeyee N. Redefining regulation of DNA methylation by RNA interference. Genomics. 2010 Jul 8.
  • Held MA, CurleyDP, Dankort D, McMahon M, Muthusamy V, Bosenberg M. Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97.
  • Smalley KS, Contractor R, Nguyen TK, Xiao M, Edwards R, Muthusamy V, King AJ, Flaherty KT, Bosenberg M, Herlyn M, Nathanson KL. Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. Cancer Res. 2008 Jul 15;68(14):5743-52.
  • Muthusamy V, Duraisamy S, Bradbury CM, Hobbs C, Curley DP, Nelson B, Bosenberg M. Epigeneticsilencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006, 66:11187-93.
  • Bosenberg M, Muthusamy V, Curley DP, Wang Z, Hobbs C, Nelson B, Nogueira C, Horner JW 2nd, Depinho R, Chin L. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice.Genesis. 2006, 44:262-7.
  • Muthusamy V , Hobbs C, Nogueira C, Cordon-Cardo C, McKee PH, Chin L, Bosenberg MW. Amplification of CDK4 and MDM2 in malignant melanoma. Genes Chromosomes Cancer. 2006, 45:447-54.

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