Ruth Halaban PhD

Senior Research Scientist in Dermatology

Research Interests

Genes controlling differentiation, proliferation and malignant transformation of melanocytes; growth factors and receptor kinases; signal transduction; epigenetic modification and gene expression; markers for melanoma

Research Summary

Genes controlling differentiation, proliferation and malignant transformation of melanocytes, growth factors and receptor kinases, signal transduction, epigenetic modification and gene expression, markers for melanoma

Selected Publications

  • Ha, B.H., M.J. Davis, C. Chen, H.J. Lou, J. Gao, R. Zhang, M. Krauthammer, R. Halaban, J. Schlessinger, B.E. Turk, and T.J. Boggon. 2012. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A.
  • Krauthammer, M., Y. Kong, B.H. Ha, P. Evans, A. Bacchiocchi, J.P. McCusker, E. Cheng, M.J. Davis, G. Goh, M. Choi, S. Ariyan, D. Narayan, K. Dutton-Regester, A. Capatana, E.C. Holman, M. Bosenberg, M. Sznol, H.M. Kluger, D.E. Brash, D.F. Stern, M.A. Materin, R.S. Lo, S. Mane, S. Ma, K.K. Kidd, N.K. Hayward, R.P. Lifton, J. Schlessinger, T.J. Boggon, and R. Halaban. 2012. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet. 44:1006-1014
  • Halaban, R., W. Zhang, A. Bacchiocchi, E. Cheng, F. Parisi, S. Ariyan, M. Krauthammer, J.P. McCusker, Y. Kluger, and M. Sznol. 2010. PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF(WT) melanoma cells. Pigment Cell Melanoma Res. 23:190-200.
  • Koga, Y., Pelizzola, M., Cheng, E., Krauthammer, M., Sznol, M., Ariyan, S., Narayan, D., Molinaro, A. M., Halaban, R., and Weissman, S. M. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res, published online June 2, 2009.
  • Halaban, R., Krauthammer, M. Pelizzola, M., Cheng, E., Kovacs, D. Sznol, M. Ariyan, S. Narayan, D., Bacchiocchi, A., Molinaro, A., Kluger, K. Deng, M., Tran, N. Zhang, W. Picardo, M., Enghild, JJ. (2009), Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical Implications. PlosOne, 4, e4563
  • Pelizzola, M., Y. Koga, et al. (2008). MEDME: An experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res 18: 1652-9.
  • Straszewski-Chavez, S. L., Visintin, I. P., Karassina, N., Los, G., Liston, P., Halaban, R., Fadiel, A., and Mor, G. (2007) XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway, J Biol Chem 282, 13059-13072

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