Christopher Gerard Bunick, MD/PhD

Assistant Professor of and Instructor in Dermatology

Research Interests

Research Organizations

Dermatology: Middlebury Dermatology

Thomas Steitz Lab

Research Summary

Dr. Bunick uses a technique called x-ray crystallography to determine the high resolution, three-dimensional structures of proteins important to both normal and diseased skin. Knowing the structure of various skin proteins enables a better understand of how a protein functions in normal and diseased skin states. Ultimately, it may lead to the development of novel therapies.

Extensive Research Description

Dr. Bunick has over 20 years of research experience in x-ray crystallography of proteins. He currently is the only American Board of Dermatology certified dermatologist who performs primary crystallography research. His current work is determining the 3D structures of proteins important for skin barrier formation. For example, he has determined the crystal structure of the N-terminus of human profilaggrin, an important protein for maintaining a normal skin barrier. Problems with profilaggrin can lead to the human skin diseases atopic dermatitis and ichthyosis vulgaris. The structural biology research in Dr. Bunick's laboratory offers biochemical understanding of how the human skin barrier forms and functions, and offers the ability to perform structure-based therapeutic design.

Selected Publications

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Contact Info

Christopher Gerard Bunick, MD/PhD
Patient Care Location
Yale Dermatology1625 Straits Turnpike, Ste Suite 306
Middlebury, CT 06762
Lab Location
Thomas A. SteitzBass Center
266 Whitney Avenue, Ste Bass 421

New Haven, CT 06511
Office Location
Yale DermatologyLaboratory for Medicine and Pediatrics
15 York Street, Ste Suite 5040

New Haven, CT 06510
Mailing Address
Yale DermatologyPO Box 208059
New Haven, CT 06520-8059

Dermatology Research in Nobel Laureate Dr. Thomas A. Steitz Laboratory