Faces of Yale Dermatology
Meet Dr. Jaehyuk Choi
Dr. Jaehyuk Choi is an Instructor in Dermatology at Yale School of Medicine where he has a research focus and a clinical interest in cutaneous oncology, specifically melanoma and cutaneous T cell lymphoma (CTCL). With a long-standing interest in CTCL, he has published articles, reviews, and book chapters on the pathogenesis of CTCL, the treatment of CTCL, and specifically the use of extracorporeal photopheresis (ECP) to treat CTCL and related diseases. Currently, he is a member of the ECP unit at Yale where he oversees the treatment of patients with advanced CTCL as well as patients with graft-versus-host disease, organ transplant rejection, as well as recalcitrant autoimmune diseases such as scleroderma. Further, he is an active participant in the monthly interdisciplinary CTCL tumor boards.
He has a research focus using genetics to better understand cancer with the ultimate goal of improving cancer therapy. In the laboratory, he is currently using forward genetic screens to interrogate cancer phenotypes. Under the mentorship of Dr. Tian Xu, he has completed a genome wide transposon insertional mutagenesis screen to identify genes that confer drug resistance to targeted therapies against melanoma. The laboratory is currently interested in using similar techniques to interrogate and therefore better understand other questions in cutaneous oncology, including CTCL. The work has been funded in part by awards from the Yale SPORE in skin cancer, the Dermatology Foundation, as well as the Skin Cancer Foundation.
In addition, Dr. Choi runs a full medical and surgical dermatology practice at the Yale Health Plan, caring for patients with complex dermatologic disease. These diseases include squamous cell carcinoma, basal cell carcinoma, psoriasis, and autoimmune connective tissue disease such as lupus, lichen planus, and sarcoidosis. He is experienced in the use of systemic dermatologic therapies including Enbrel, Humira, Stelara, and other steroid sparing agents. He also has collaborated and works with the Yale Cancer Center Genetic Counseling Program. Patients with a genetic predisposition to internal cancer may have unique dermatologic concerns. He cares for these patients as needed to help with diagnosis, manage dermatologic issues, as well as screen for skin cancer, for which some of these patients have an elevated risk.