Felix R. Wolf, DVM, PhD
Adjunct Associate Professor, Comparative Medicine
Associate Professor, Weill Cornell Medical College
Laboratory Member, Memorial Sloan-Kettering Cancer Center
1275 York Avenue Box 270
New York, New York 10075
Phone: (646) 888-2403
Fax: (646) 422-0139
- VMD, University of Zurich
- PhD, University of Zurich
My research has mainly focused on the pathogenesis of viral infections in rodents. The primary agent I examined was mouse hepatitis virus (MHV). Initially as part of a research group at Yale under the leadership of Steve Barthold and later independently with my own students I looked at pathogenesis and tissue tropism of various enterotropic MHV strains using both in vivo and in vito models. In addition I studied other infectious agents such as the rat adenovirus and the guinea pig adenovirus.
Another focus of my research is health monitoring in rodent colonies. I have studied transmission of infectious agents within colonies as well as detection of these agents both on the animal facility side (sentinels) as well as diagnostic assays for the laboratory. I developed and validated the first battery of real-time PCR assays to replace the traditional mouse antibody production (MAP) test to detect infectious contaminants in biologicals such as transplantable tumors.
Currently I am looking at novel and improved diagnostic and treatment options for murine ectoparasites. This includes a simple and economical treatment regime for large rodent colonies that has none or minimal side effects and a serological test for ectoparasites that allows screening of large groups of animals.
Laboratory Animal Medicine
Publications of Note
Cohen JK, Kilpatrick AM, Stroud FC, Paul K, Wolf F, Else JG (2007) Seroprevalence of West Nile virus in nonhuman primates as related to mosquito abundance at two national primate research centers. Comp Med. 57(1):115-9.
Compton SR, Homberger FR, MacArthur Clark J (2004) Microbiological monitoring in individually ventilated cage systems. Lab Anim (NY). 33(10):36-41.
Compton SR, Homberger FR, Paturzo FX, Clark JM (2004) Efficacy of three microbiological monitoring methods in a ventilated cage rack. Comp Med. 54(4):382-92.
Bootz F, Sieber I, Popovic D, Tischhauser M, Homberger FR (2003) Comparison of the sensitivity of in vivo antibody production tests with in vitro PCR-based methods to detect infectious contamination of biological materials. Lab Anim. 37(4):341-51.
Pullium JK, Homberger FR, Benjamin KA, Dillehay DL, Huerkamp MJ (2003) Confirmed persistent mouse hepatitis virus infection and transmission by mice with a targeted null mutation of tumor necrosis factor to sentinel mice, using short-term exposure. Comp Med. 53(4):439-43.