Sabrina Diano, PhD

Professor of Obstetrics, Gynecology, and Reproductive Sciences, of Comparative Medicine and of Neuroscience; Director, Reproductive Neurosciences Group

Research Interests

Endocrine System; Nervous System; Diseases

Research Organizations

Obstetrics, Gynecology & Reproductive Sciences: Reproductive Neurosciences Group | Reproductive Sciences: diano lab; Discovery to Cure Internship

Comparative Medicine: Integrative Cell Signaling & Neurobiology of Metabolism (ICSNM)

Diabetes Research Center

Faculty Research

Interdepartmental Neuroscience Program

Office of Cooperative Research

Research Summary

My research focuses on CNS (hypothalamic) mechanisms relating to the regulation of energy and glucose homeostasis. These studies on hypothalamic inter- and intra-cellular mechanisms that regulates metabolism add critical information to the current understanding of the central regulation of energy and glucose homeostasis and how alterations in stored energy are sensed in the hypothalamus. The results of my research have important implications for understanding the pathogenesis of metabolic syndrome, obesity and type 2 diabetes, disorders that are the leading cause of morbidity and mortality in the U.S., and the developed world in general, with the highest financial burden on the national economy.

Selected Publications

  • DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. Cell Metab. 2017 Mar 7;25(3):647-660. doi: 10.1016/j.cmet.2017.01.003. Epub 2017 Feb 9. PMID: 28190775
  • POMC Neurons: From Birth to Death. Toda C, Santoro A, Kim JD, Diano S. Annu Rev Physiol. 2017 Feb 10;79:209-236. doi: 10.1146/annurev-physiol-022516-034110. PMID: 28192062
  • UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S. Cell. 2016 Feb 25;164(5):872-83. doi: 10.1016/j.cell.2016.02.010. PMID: 26919426
  • Hypothalamic POMC neurons promote cannabinoid-induced feeding. Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Nature. 2015 Mar 5;519(7541):45-50. doi: 10.1038/nature14260. Epub 2015 Feb 18. PMID: 25707796

Full List of PubMed Publications

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Contact Info

Sabrina Diano, PhD
Mailing Address
Department of Obstetrics, Gynecology & Reproductive Sciences333 Cedar Street
New Haven, CT 06510-