Endocrine System; Nervous System; Diseases
My research focuses on CNS (hypothalamic) mechanisms relating to the regulation of energy homeostasis, with emphasis on hormone action in the hypothalamus. These studies on hypothalamic inter- and intra-cellular mechanisms that regulates energy metabolism add critical information to the current understanding of the central regulation of energy balance and how alterations in stored energy are sensed in the hypothalamus. The results of my research have important implications for understanding the pathogenesis of metabolic syndrome, obesity and type 2 diabetes, disorders that are the leading cause of morbidity and mortality in the U.S., and the developed world in general, with the highest financial burden on the national economy.
- Diano S, Horvath TL. (2010) A sympathetic view on free radicals in diabetes. Neuron 66(6):809-11.
- Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, Diano S. (2009) Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. J Clin Invest. 119(8):2291-303.
- Andrews ZB, Liu ZW, Wallingford N, Erion DM, Borok E, Friedman JM, Tschoep MH, Shanabrough M, Cline GM, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S (2008) UCP2 mediates ghrelin’s action on NPY/AgRP neurons. Nature 454(7206):846-51.