Selected Publications



Idevall-Hagren O, and De Camilli P. Detection and manipulation of phosphoinositides  (2015).  Biochim. Biophys. Acta.  [Epub ahead of print]. 

Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia NT, Shulman GI, Bagriantsev SN, Gracheva EO*.(2015). Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.PNAS112(5):1607-12.


Kosmaczewski, SG, Edwards, TJ, Han, SM, Eckwahl, MJ, Meyer, B, Peach, S, Hesselberth, J, Wolin, SL, and Hammarlund, M.(2014). The RtcB RNA ligase is an essential component of the metazoan unfolded protein response.EMBO Reports 15, 1278-85. PMCID: PMC4264930.

Cao M, Milosevic I, Giovedi S, and De Camilli P.  ( Up-regulation of Parkin in endophilin mutant mice2014)  .  J. Neurosci.  34: 16544-16549.  PMCID: PMC4252559

Bagriantsev SN, Gracheva EO*.(2014). Molecular mechanisms of temperature adaptations.J Physiol.E-pub Nov 28.

Zhang, Y-Q and Chandra, SS.(2014). Oligomerization of Cysteine String Protein alpha mutants causing adult neuronal ceroid lipofuscinosis.BBA Molecular Basis of Disease. 1842, 2136-2146. PMID: 25064588

Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM.(2014). Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice. Brain Res. 1588:168-74.

Bagriantsev SN, Gracheva EO, Gallagher PG. (2014). Piezo Proteins: Regulators of mechanosensation and other cellular processes.J Biol Chem2014, 289(46):31673-31681.

Kumar A, Wu Y, Christensen R, Chandris P, Gandler W, McCreedy E, Bokinsky A, Colón-Ramos DA, Bao Z, McAuliffe M, Rondeau G, Shroff H.(2014). Dual-view plane illumination microscopy for rapid and spatially isotropic imaging. Nat Protoc . 9(11):2555-73. doi: 10.1038/nprot.2014.172. PMID:25299154

Haas LT, Kostylev MA, Strittmatter SM.(2014). Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5). J Biol Chem. 289(41):28460-77

Lee, H, Kim, SA, Mugno, P, Hammarlund, M,Hilliard, MA, and Lu, H.(2014). A Multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features inC. elegans. Lab Chip 14, 4513-22. PMCID: PMC4213302.

Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG,Gracheva EO Bagriantsev SN., (2014).Neuronal mechanism for acute mechanosensitivityin tactile-foraging waterfowl.PNAS (Cover).111(41):14941-6.

Higley MJ.(2014). Localized GABAergic inhibition of dendritic Ca(2+) signalling. Nat Rev Neurosci.15(9):567-72. doi: 10.1038/nrn3803.

Nandez R, Balkin DM, Messa M, Paradise S, Czapla H, Hein MY, Mann M, and De Camilli P. A role of OCRL in clathrin-coated pit fission and uncoating revealed by studies of Lowe syndrome cells(2014).  .  Elife. 3:e02975

Schwab ME, Strittmatter SM.(2014). Nogo limits neural plasticity and recovery from injury. Curr Opin Neurobiol. 27:53-60

Messa M, Fernandez-Busnadiego R, Sun EW, Chen H, Czapla H, Wrasman K, Wu Y, Ko G, Ross T,Wendland B, and De Camilli P. Epsin deficiency impairs endocytosis by stalling the actin- dependent invagination of endocytic clathrin coated pits.  (2014).    Elife.  3: e03311.  PMCID: PMC4161027

Stagi M, Klein ZA, Gould TJ, Bewersdorf J, Strittmatter SM.(2014). Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.Mol Cell Neurosci. 61:226-40.

Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, DeCamilli P.(2014).Coupling between endocytosis and sphingosine kinase 1 recruitment.Nat. Cell Biol.  16:652-662.  PMCID: PMC3557052

Strittmatter SM.(2014). Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks. Nat Med. 20(6):590-1

Edwards, TJ and Hammarlund, M.(2014). Syndecan promotes axon regeneration by stabilizing growth cone migration.Cell Reports 8, 1-12. PMCID: PMC4127196. 

Vargas, KJ, Makhani, S, Davis, T, Westphal, C, Castillo, PE, and Chandra, SS.(2014). Synucleins regulate the kinetics of synaptic vesicle endocytosis.J. Neuroscience.34, 9364-9376.PMID: 25009269.Cover Article

Luo L, Wen Q, Ren J, Hendricks M, Gershow M, Qin Y, Greenwood J, Soucy ER, Klein M, Smith-Parker HK, Calvo AC, Colón-Ramos DA, Samuel AD, Zhang Y.(2014). Dynamic encoding of perception, memory, and movement in a C. elegans chemotaxis circuit. Neuron.82(5):1115-28.

Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR,  De Camilli P*, and Reinisch KM*.  (2014). Structure of a lipid-bound Extended-Synaptotagmin indicates a role in lipid transferNature.  510: 552-555. PMCID: PMC4135724 

Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson P, Ferguson SM, De Camilli P. (2014).A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.  Elife. 3: e01621.  PMCID: PMC4107917

Luo L, Cook N, Venkatachalam V, Martinez-Velazquez LA, Zhang X, Calvo AC, Hawk J, MacInnis BL, Frank M, Ng JH, Klein M, Gershow M, Hammarlund M, Goodman MB, Colón-Ramos DA, Zhang Y, Samuel AD.(2014).Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons. Proc Natl Acad Sci 111, 2776-81. PMCID: PMC3932917.

Nygaard HB, van Dyck CH, Strittmatter SM.(2014). Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimers Res Ther. 6(1):8

Schneider ER, Anderson EO,Gracheva EOBagriantsev SN.(2014). Temperature sensitivity of two-pore (K2P) potassium channels.Curr Top Membr74:113-33.

Byrne, A. B., Walradt, T., Gardner, K. E., Hubbert, A., Reinke, V., and Hammarlund, M.(2014). Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration. Neuron 81, 1-13. PMCID: PMC3924874.

Nix, P, Hammarlund, M, Hauth, L, Lachnit, M, Jorgensen, EM, and Bastiani, MJ.(2014). Axon Regeneration Genes Identified by RNAi Screening inC. elegans.J Neuroscience 34, 629-645. PMCID: PMC3870940.
Laursen WJ, Bagriantsev SN, Gracheva EO. (2014). TRPA1 Channels: chemical and temperature sensitivity. Curr Top Membr2014, 74:89-112. 

Zhang F, Bhattacharya A, Nelson JC, Abe N, Gordon P, Lloret-Fernandez C, Maicas M, Flames N, Mann RS, Colón-Ramos DA, Hobert O.(2014). The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types. Development 141(2):422-35


Nelson JC, Colón Ramos DA. Serotonergic neurosecretory synapse targeting is controlled by netrin-releasing guidepost neurons in Caenorhabditis elegans. J.Neurosci (2013) Jan23, 33 (4): 1366-76 PMID: 23345213 

Yan D, Yamasaki M, Straub C, Watanabe M, Tomita S (2013) Homeostatic control of synaptic transmission by distinct glutamate receptors. Neuron. 2013 May 22;78(4):687-99. dol:10.1016/j.neuron.2013.02.031

Recessive  loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration. Proc. Natl. Acad. Sci,(2013) USA Feb 26;110(9):3489-94. doi:10.1073/pnas.1222732110. Epub 2013 Jan 28.

Westphal, C. and Chandra, S.S. Monomeric Synucleins generate membrane curvature J. Biol Chem. 2013 288:  1829-1840 PMID: 23184946

Akbik FV, Bhagat SM, Patel RR, Cafferty WBJ, Strittmatter SM.  Anatomical Plasticity of Adult Brain is Titrated by Nogo Receptor 1. Neuron, (2013) Mar 6;77 (5) :859-66. PMID: 23473316

Wu, M., Wu, X., DeCamilli, PCalcium oscillations-coupled conversion of actin travelling waves to standing oscillations. PNAS (2013) 110 (4) 1339-1344

Giordano F, Saheki Y, Idevall-Hagren O, Colombo S, Pirruccello M, Milosevic I, Gracheva E, Gagriantsev SN, Borgese N and De Camilli P., PI (4,5)P2-Dependent And C A2+-Regulated ER-PM Interactions Mediated by the Exetended-Synaptotagmins. Cell. 153: 1494-1509

Ju H, Kokubu H, Todd TW, Kahle JJ, Kim S, Richman R, Chirala K, Orr HT, Zoghbi HY, and Lim J.(2013). Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. Journal of Neuroscience 33, 9328-9336. 


Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJCompartmentalization of GABAergic inhibition by dendritic spines.Science. 2013 May 10;340(6133):759-62. doi: 10.1126/science.1234274. 

Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley JF, Sabatini BL, Ellis-Davies GC. Optically selective two-photon uncaging of glutamate at 900 nm.  J Am Chem Soc. 2013 Apr 24;135(16):5954-7. doi: 10.1021/ja4019379. Epub 2013 Apr 11 

Williams DC, El Bejjani R, Ramirez PM, Coakley S, Kim S, Lee H, Wen Q, Samuel A, Lu H, Hillard MA and Hammarlund MRapid and permanent neuronal inactivation in vivo via subcellular generation of reactive oxygen using KillerRed.  Cell Reports (2013) 5, 553-63. PMCID:  PMC3877846

Firnhaber C, and Hammarlund MNeuron-specific feeding RNAi in C. elegans, and it's use in a screen for essential genes required for GABA neuron function.  PLoS Genetics (2013) 9 (11):e1003921. PMCID: PMC3820814

Guerrero-Medina G, Feliu-Mojer M, Gonzalez-Espada W, Diaz-Munoz G, Lopez M, Diaz-Munoz S, Fortis-Santiago Y, Flores-Otero J, Craig C,Colón Ramos DA. Supporting Diversity in Science through Social Networking.  Plos Biology 2013 Dec; 11(12); e1001740. PMID: 24391467

Wu Y, Wawrzusin P, Senseney J, Fischer RS, Christensen C, Santella A, York AG, Winter PW, Waterman CM, Bao Z,Colón Ramos DA, McAuliffe M and Shroff H. Volumetric Isotropic Imaging with Dual-view Plane Illumination Microscopy. 2013 Nature Biotechnology Oct 13 PMID 24108093



Bejjani RE, Hammarlund M.Notch signaling inhibits axon regenerationNeuron. 2012 Jan 26;73(2):268-78. PMID: 22284182

Smith C.J., WatsonJ.D., VanHoven M., Colón-Ramos D.A., Miller III D.M.UNC-6/Netrin mediates dendritic self-avoidance 3rd.Nat Neurosci. 2012 15(5):731-7.PMID:22426253[PubMed - indexed for MEDLINE]

Stavoe A.K.H., Colón-Ramos D.A. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10/Lamellipodin and the actin cytoskeleton. J Cell Biol. 2012 Apr 2;197(1):75-88. PMID:22451697[PubMed - indexed for MEDLINE]

Duffy P, Wang X, Seigel CS, Tu N, Henkemeyer M, Cafferty WBJ, Strittmatter SMMyelin-Derived EphrinB3 Restricts Axonal Regeneration and Recovery after Adult CNS Injury. Proc. Natl. Acad. Sci. USA, 109: 5063-8 (2012).

Higley MJ, Sabatini BL.Calcium Signaling in Dendritic Spines . Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a005686. PMID: 22338091.

Zhang, Y., Henderson, M.X., Colangelo, C.M., Ginsberg, S., Bruce, C., Terence Wu, T., Chandra, S.S.Identification of CSP a clients reveals a role in dynamin 1 regulation. .Neuron74: 136-50.PMID: 22500636 

Scott K, Hammarlund M.Science in Suzhou: establishment and function of neural circuits . EMBO Rep. 2012 13 (4): 286-8 PMID:22402665

Ferguson SM, and De Camilli P.
2012.Dynamin, a membrane-remodelling GTPase.Nat. Rev. Mol. Cell Biol.13: 75-88.

Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger L, Ferguson S, and De Camilli P.
2012. Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. Proc. Nat. Acad. Sci.109: 515-523.PMCID: PMC3286982

Pirruccello M, and De Camilli P. 2012. Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL. Trends. Biochem. Sci. 37:134-143. PMICD: PMC3323734

Saheki Y, and De Camilli P.2012.Synaptic vesicle endocytosis.In The Synapse. Eds.M. Sheng & B Sabatini, T.C. Südhof.Cold Spring Harb Perspect Biol.

Idevall-Hagren O, Dickson EJ, Hille B, Toomre DK, andDe Camilli P. 2012. Optogenetic control of phosphoinositide metabolism. Proc. Nat. Acad. Sci. 109: 2316-2323.PMCID: PMC3435206

Shen H, Pirruccello M and De Camilli P.2012. SnapShot: Membrane Curvature Sensors and Generators.Cell, 150: 1300-1300.e2

Stavoe AK, Nelson JC, Martínez-Velázquez LA, Klein M, Samuel AD, Colón-Ramos DASynaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin..Genes Dev. 2012 Oct 1;26(19):2206-21. PMID:23028145

Picciotto MR, Higley MJ, Mineur YS.Acetylcholine as a neuromodulator:cholinergic signaling shapes nervous system function and behavior. Neuron. 2012Oct 4;76(1):116-29. PMID: 23040810;PubMed Central PMCID: PMC3466476.

Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC, Strittmatter SM. Alzheimer Amyloid-ß Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons. Nat Neurosci. 15:1227-1235 (2012). PMID: 22820466

El Bejjani, R., Hammarlund, M.Neural regeneration in Caenorhabditis elegans. Annu Rev Genet. 46:499-513. PMID: 22974301

Nakatsu, F., Baskin, J.M., Chung, J., Tanner, L.B., Shui, G., Lee, S.Y., Pirruccello, M, Hao, M., Ingolia, N.T., Wenk, M.R., DeCamilli, P.  Ptdlns4P synthesis by Pl4klllα at the plasma membrane and its impact on plasma membrane identity. J. Cell Biol. 199 (6): 1003-1016. 

Soda, K, Balkin, D.M., Ferguson, S.M., Paradise, S, Milosevic, I., Giovedi, S., Volpicelli-Daley, L., Tian, X., Wu, Y., Ma, H., Son, S.H., Zheng, R., Moeckel, G., Cremona, O., Holzman, L.B., DeCamilli, P., Ishibe, S.Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest 2012,; 122 (12): 4401-4411


Gill MB, Kato AS, Robert MF, Yu H, Wang H, Tomita S, and Bredt DS (2011) Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. Journal of Neuroscience, 31, 6928-6938 PMCID:

Straub C, Hunt DL, Yamasaki M, Kim KS, Watanabe M, Castillo PE, and Tomita S (2011) Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nature Neurosci., 14, 866-873 PMCID: PMC3125417 

Sumioka A, Brown T, Kato AS, Bredt DS, Kauer JA, and Tomita S. (2011)   PDZ binding of TARPγ-8 controls synaptic transmission, but not synaptic plasticity. Nature Neurosci., 14, 1410-1412 PMCID: PMC3206644 

Kahle JJ, Gulbahce N, Shaw CA, Lim J, Hill DE, Barabási A-L, and Zoghbi HY. (2011)    Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Hum. Mol. Genet. 20, 510-527. PMID: 21078624 

Rankin BR, Moneron G, Wurm CA, Nelson JC, Walter A, Schwarzer D, Schroeder J, Colón-Ramos DA, Hell SW.   Nanoscopy in a Living Multicellular Organism xpressing GFP.Biophys J. 2011;100(12):L63-5. PMCID: 3123922 

Wu Y., Ghitani A., Christensen R., Santella A., Bao Z.*, Colón-Ramos DA*, Shroff H*   A selective plane illumination microscope for high-speed C. elegans embryogenesis studies. PNAS 2011 Oct 25;108(43):17708-13. 

Christensen R., de la Torre-Ubieta L., Bonni A., Colón-Ramos DA.    A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
Development 2011 Dec; 138(23)5257-67 

Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL.   Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One. 2011 Apr 22;6(4):e19155. PubMed PMID: 21544206 

Pirruccello M, Swan LE, Folta-Stogniew E, and De Camilli P.    Recognition of the F&H motif by the Lowe Syndrome protein OCRLNature Struct. Mol. Biol. 2011. 18: 789-795 

Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Paradise S, Shen H, O’Toole E, Ferguson S, Cremona O, and De Camilli P.    Recruitment of endophilin to clathrin coated pit necks is required for uncoating but is dispensable for fissionNeuron.2011.72: 587-601 

Anwar, S., Peters, O., Millership, S., Ninkina, N., Doig, N., Connor-Robson, N., Threlfell, S., Kooner, G., Deacon, R., Bannerman, D.M., Bolam, J., Chandra, S., Cragg, S., Wade-Martins, R., and Buchman, V.   Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J. Neuroscience (2011).31:7264-7274. PMID:21593311 

Byrne AB, Edwards TJ, Hammarlund M. In vivo laser axotomy in C. elegans. J Vis Exp. 2011 May 19;(51). pii: 2707. doi: 10.3791/2707. PMID:21633331 

Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.Science. 333:769-773. (2011) PubMed PMID: 21817055. 

Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB, Strittmatter SM.   Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 70:805-821 (2011).