Jaime Grutzendler MD

Associate Professor of Neurology and of Neurobiology; Director, Yale Center for Experimental Neuroimaging (YCEN)

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Medicine, Pharmacology, and Physiology

Interdepartmental Neuroscience Program

Cancer Center, Yale: Signal Transduction

Vascular Biology and Therapeutics Program


Neurology: Alzheimer's Disease/Dementia and Neuro-degenerative Disorders | Grutzendler Lab

Research Interests

Neuro-glio-vascular interactions, cerebral blood flow and metabolism blood-brain barrier, two-photon microscopy, myelin imaging, synaptic plasticity, development and pathology of the brain microvasculature, Neuroinflammationin, neurodegenerative diseases and stroke  more...


  • M.D., Universidad Javeriana School of Medicine, 1991

Selected Publications

  • Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Schain A, Hill R, Grutzendler J. Nature Medicine. 2014 Mar 30; Epub 2014 Mar 30.
  • Angiophagy prevents early embolus washout but leads to microvascular recanalization through embolus extravasation. Grutzendler J, Murikinati S, Hiner B ,Lam C , Yoo T ,Ji L, Hafler B, Adelman R ,Gupta S, Yuan P, Rodriguez G. Science Translational Medicine. 2014. 6:226-231
  • Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.C. Whiteus, C. Freitas, J. Grutzendler. Nature. 2013, Dec 04 .505, 407–411



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