Flora Maria Vaccarino, MD

Harris Professor in the Child Study Center; Professor in the Department of Neuroscience

Departments & Organizations

Child Study Center: Albert J. Solnit Integrated Training | Albert J. Solnit Integrated Training Program | Child & Adolescent Psychiatry Training Program | Family, Genetic and Molecular Research | NIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders | Tourette’s Syndrome & Obsessive-Compulsive Disorders | Vaccarino Lab

Interdepartmental Neuroscience Program

Kavli Institute for Neuroscience

Office of Student Research

Program in Neurodevelopment and Regeneration

Stem Cell Center, Yale: Stem Cell Genetics

WHRY Pilot Project Program Investigators

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Developmental Biology | Neuroscience: Cognitive/Learning and Memory; Development; Molecular/Cellular Neuroscience


Dr. Flora Vaccarino graduated in Medicine at Padua University in Italy and studied neuropharmacology and cell biology at NIH as a research fellow before starting her Residency in Psychiatry at Yale University. After her residency, she studied developmental biology and genetics and was appointed Assistant Professor at Yale University in 1994. She then pursued several lines of research, using genetic mouse models as well as human brain specimens, to understand the pathophysiology of neuropsychiatric disorders. Her 1999 paper in Nature Neuroscience (Vaccarino et al,1999) showing that a single administration of Fibroblast Growth Factor 2 can induce permanent increases in cerebral cortical size, embodies the powerful role of these factors in development and evolution.
Together with people in her lab, Dr. Vaccarino, now a full Professor at Yale University School of Medicine, studies mouse and human neural stem cells and their role in development and repair. She and a group of colleagues recently founded the Program in Neurodevelopment and Regeneration to harness the power of induced pluripotent stem cells for understanding individual variation in neurodevelopment and the pathophysiology of neuropsychiatric disorders.

Education & Training

MD Padua University Medical University (1979)
Resident Yale University, School of Medicine, Psychiatry
Visiting Assistant Professor FIDIA-Georgetown Institute for the Neurosciences
Research Fellow NIMH-Laboratory of Preclinical Pharmacology

Honors & Recognition

  • FellowAmerican Association for the Advancement of Science (AAAS) (2015)

  • NARSAD Distinguished Investigator AwardNARSAD (2011)

  • Collegio dei Docenti, Dottorato di Ricerca in Neuropsicofarmacologia Clinica e SperimentaleUniversity of Messina, Italy (2011)

  • Harris Endowed ProfessorshipChild Study Center, Yale University School of Medicine (2010)

  • Executive CouncillorInternational Society for Developmental Neuroscience (2008)

  • Tourette’s Syndrome Association AwardTourette’s Syndrome Association (2004)

  • NARSAD Independent Investigator Award NARSAD (2003)

  • Essel InvestigatorNARSAD (2003)

  • NARSAD Independent Investigator AwardNARSAD (2000)

  • Tourette’s Syndrome Association AwardTourette’s Syndrome Association (1998)

  • Professional Opportunities for Women in Research & Education AwardNational Science Foundation (1997)

  • NARSAD Young Investigator AwardNARSAD (1993)

  • Lustman AwardYale University (1991)

  • NARSAD Young Investigator AwardNational Alliance for Research in Schizophrenia and Depression (1990)

  • Rotary International Educational AwardRotary Foundation (1981)

Professional Service

  • Member, YSM Faculty Advisory Council Yale School of Medicine (2015)

  • Scientific Advisory, Yale Genome Editing Center Yale University (2015)

  • Clinical and Translational Strategic Planning Committee Yale University (2015)

  • Ad hoc Member, ZRG1 BDCN-C (02) Special Emphasis Panel: Brain Disorders in Animal Models and Patient Populations NIH (2014 - 2014)

  • Ad hoc Member, Silvio O. Conte Centers for Basic or Translational Mental Health Research Panel, NIMH NIH (2013 - 2013)

  • Member, NIMH Repository & Genomics Resource (RGR) Steering Committee NIH (2013)

  • Scientific Committee member Telethon , Italy (2013)

  • Human Embryonic Stem Cell Oversight Committee (ESCRO) Yale University (2013)

  • Associate Editor Journal of Neuroscience (2013)

  • Senior Editor Brain Research (2011)

  • Senior Faculty Allotment Committee Yale University School of Medicine (2009 - 2012)

  • International Journal of Developmental Neuroscience International Society of Developmental Neuroscience (2008)

  • Associate Editor Frontiers in Neurogenesis (2008)

  • Funds and Fellowships Committee Yale University School of Medicine (2006 - 2009)

  • Developmental Brain Disorders (DBD) Study Section, NIH NIH (2005 - 2009)

  • Animal Users Committee Yale University (2004)

  • Member Society for Neuroscience (1983)

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Contact Info

Flora Maria Vaccarino, MD
Mailing Address
PO Box 207900
230 South Frontage Road

New Haven, CT 06520-7900

Curriculum Vitae

Program in Neurodevelopment and Regeneration

Vaccarino Lab

Human iPSC- derived telencephalic organoid

Telencephalic organoid derived from human iPSC and grown in 3D culture. Red, progenitor cells stained for SOX1; green, immature neurons stinaed for bIII tubulin.