Research in the Rothman Lab

SNARE Overview

Over 30 years ago, we observed what we interpreted to be vesicular transport in crude extracts of tissue culture cells. In subsequent years we found... more...

Current Research & Projects

Our lab is working to elucidate the underlying mechanisms of vesicular transport within cells and the secretion of proteins and neurotransmitters. We take an interdisciplinary approach which includes cell-free biochemistry, single molecule biophysics, high resolution optical imaging of single events/single molecules in the cell and in cell-free formats. more...

The Mechanism of SNARE-Mediated Fusion

more...

Regulation of Membrane Fusion

more...

Structural and Functional Organization of the Golgi Apparatus

more...