Selected References

  • Kümmel, D., Krishnakumar, S.S., Radoff, D.T., Li, F., Giraudo, C.G., Pincet, F., Rothman, J.E., and Reinisch, K.M. "Complexin Cross-links Pre-fusion SNAREs Into a ZigZag Array"  Nat. Struct. Mol. Biol. (2011) 18, 927-33.
  • Krishnakumar, S.S., Radoff, D.T., Kümmel, D, Giraudo,C.G., Li, F., Khandan, L., Baguley, S.W., Coleman, J., Reinisch, K.M., Pincet, F., and Rothman, J.E. "A Conformational Switch in Complexin is Required for Synaptotagmin to Trigger Synaptic Fusion" Nat. Struct. Mol. Biol. (2011) 18, 933-40.
  • Li, F., Pincet, F., Perez, E., Giraudo, C.G., Tareste, D., and Rothman, J.E. " Complexin Activates and Clamps SNAREpins by a Common Mechanism Involving an Intermediate Energetic State" Nat. Struct. Mol. Biol. (2011) 18, 941-46.
  • Lavieu, G., Orci, L., Shi, L., Geiling, M., Ravazzola, M., Wieland, F., Cosson, P. and Rothman, J. E. “Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes” Proc. Natl. Acad. Sci. (2010) 107, 6876-81.
  • Karatekin, E., Di Giovanni, J., Iborra, C., Coleman, J., O'Shaughnessy, B., Seagar, M. and Rothman, J. E. “A fast, single-vesicle fusion assay mimics physiological SNARE requirements” Proc. Natl. Acad. Sci. (2010) 107, 3517-21
  • Giraudo Claudio G; Garcia-Diaz Alejandro; Eng William S; Chen Yuhang; Hendrickson Wayne A; Melia Thomas J; Rothman James E. Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (New York, N.Y.) 2009;323(5913):512-6.
  • Paumet Fabienne; Wesolowski Jordan; Garcia-Diaz Alejandro; Delevoye Cedric; Aulner Nathalie; Shuman Howard A; Subtil Agathe; Rothman James E. Intracellular bacteria encode inhibitory SNARE-like proteins. PloS one 2009;4(10):e7375.
  • Giraudo Claudio G; Garcia-Diaz Alejandro; Eng William S; Yamamoto Ai; Melia Thomas J; Rothman James E. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. The Journal of biological chemistry 2008;283(30):21211-9.
  • Tareste David; Shen Jingshi; Melia Thomas J; Rothman James E. SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2380-5.
  • Shen, J., Tareste, D.C., Paumet, F., Rothman, J.E., Melia T.J., 2007. Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins. Cell. 128(1):183-95.
  • Giraudo, C.G., Eng, W., Melia, T.J., Rothman, J.E. 2006. A Clamping Mechanism Involved in SNARE-Dependent Exocytosis. Science 313:677-680.
  • Li, F., Pincet, F., Eng, W., Melia, T., Rothman, J.E., and Tareste, D. 2007. Energetics and dynamics of SNAREpin folding across lipid bilayers.  Nature Structural & Molecular Biology 14: 890-896.
  • Rothman, J.E. 2002. Lasker Basic Medical Research Award. The machinery and principles of vesicle transport in the cell. Nature Med. 8:1059-1062.
  • Pelham, H.R.B., and Rothman, J.E.  2000.  The debate about transport in the Golgi – Two sides of the same coin?  Cell  102:713-719