Frederic Pincet, Ph.D.

I am a CNRS scientist from the Laboratoire de Physique Statistique of the Ecole Normale Supérieure in Paris, France, where I am interested in various interactions of membranes and/or single molecules. During my sabbatical stay in the laboratory of Prof. J. Rothman I am studying the thermo-mechanical impact of SNAREpins on membranes by combining theoretical predictions and micromanipulation experiments.

Selected recent publications:

• J. Husson, F. Pincet, "Analyzing single-bond experiments : Inflence of the shape of the energy landscape and universal law between the width, depth, and force spectrum of the bond", Physical Review E, vol. 77, Art. No 026108 (2008)
• A. Jegou, F. Pincet, E. Pérez, J. Wolf, A. Ziyyat et C. Gourier, "Mapping mouse gamete interaction forces reveal several oocyte membrane regions with different mechanical and adhesive properties", Langmuir, vol. 24, pp. 1451-1458 (2008)
• P. Hermand, F. Pincet, S. Carvalho, H. Ansanay, E. Trinquet, M. Daoudi, C. Combadière and P. Deterre, "Functional adhesiveness of the CX3CL1 chemokine requires its aggregation: Role of the transmembrane domain", Journal of Biological Chemistry (2008) In Press.
• F. Li et F. Pincet, "Confinement free energy of surfaces bearing end-grafted, polymers in the mushroom regime and local measurement of the polymer density", Langmuir, 23, 12541-12548 (2007) F. Pincet, "Membrane Recruitment of Scaffold Proteins Drives Speciffic Signaling", PLoS ONE, vol. 10, Art. No e977 (2007)
• F. Li, F. Pincet, E. Pérez, W. Eng, T. Melia, J. Rothman et D. Tareste, "Energetics and dynamics of SNAREpin folding across lipid bilayers", Nature Structural & Molecular Biology, vol. 14, pp. 890-896(2007)
• N. Rodriguez, S. Cribier et F. Pincet, "Transition from long- to short-lived transient pores in giant vesicles in an aqueous medium", Physical Review E, vol. 74, Art. No 061902 (2006)
• F. Pincet et J. Husson, "The solution to the streptavidin-biotin paradox: The influence of history on the strength of single molecular bonds", Biophysical Journal, vol. 89, pp. 4374-4381 (2005)
• Y. Chu, S. Dufour, J. Thiery, E. Pérez et F. Pincet, "Johnson-Kendall-Roberts theory applied to living cells", Physical Review Letters, vol. 94, Art. No 028102 (2005)