Departments & Organizations
Cell Biology: Carroll Lab
Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS): DNA Dynamics and Transcriptional Regulation; Membrane Biology | Molecular Cell Biology, Genetics and Development: Cell Biology; Epigenetics; Human Disease; Molecular Mechanisms; Nuclear Dynamics; Signal Transduction
The eukaryotic genome is highly organized within the nucleus. This organization occurs at several different spatial scales, ranging from local interactions between proximal nucleosomes to the global positioning of large chromosomal domains within specific nuclear compartments. The Carroll lab is interested in understanding the molecular mechanisms that that control nuclear organization, and further, how these mechanisms are integrated to ensure the integrity and proper expression of the genome. We take an interdisciplinary approach using biochemistry, cell biology, genomics, and proteomics to address these questions.
I first became interested in chromosome structure and dynamics as a graduate student in Dr. David Morgan's lab at UCSF where I studied the molecular mechanisms that control chromosome segregation during mitosis. I then moved to Stanford University School of Medicine to do a postdoc for Dr. Aaron Straight. As a postdoc, I developed biochemical and cell biological methods to dissect how the specialized chromatin environment of the centromere directs kinetochore assembly during mitosis. It was during this time that I became interested in understanding how specific regions of chromosomes are specialized for particular functions, and in particular, how the spatial organization of the genome influences these decisions.
Education & Training
|PhD||University of California-San Francisco (2005)|
|BS||University of California at Santa Cruz (1997)|
|Postdoctoral Fellow||Stanford School of Medicine|
Honors & Recognition
Postdoctoral FellowshipAmerican Heart Association (2009)
Postdoctoral FellowshipHelen Hay Whitney Foundation (2006)