Services & Rates

New Services

We offer a startup package for electron tomography. The purpose is to provide investigators with an opportunity to try out this new technique and determine whether it would be a good addition to their current portfolio of conventional electron microscopy projects. The package includes generating two tomograms at both high and low magnification levels. We will prepare sample grids, collect image data from the high tilting range, process acquired images, and reconstruct data into 3-dimensional tomograms. The flat-rate charge is $250 for the first image data set (single-axis). Subsequent tomograms will be $200 for a single-axis tilt and $350 for a dual-axis collection.

Biological EM facility provides the following services:

  • Sample processing, embedding in plastic resin
  • Ultramicrotomy of plastic sections
  • Cryo-sectioning and immuno-gold labeling
  • Negative staining
  • Immuno-electron microscopy
  • Sputter coating
  • Assisting in transmission electron microscopy and digital imaging
  • Consultation and assistance in design of EM experiments
  • Electron tomography: tilt series acquisition, image alignment and reconstruction for plastic embedded samples

Cryo EM facility service:

This facility is a "user facility" and currently does not provide cryo EM service. Any parties interested in having samples evaluated for suitability for cryo EM work should contact EM facility director, Xinran Liu


Regular services are invoiced monthly after a project is completed.

Service                   Yale          Other
Staff Time / hour$65$78$130
Samples embedding (1-4)$250$300$500
Samples embedding (4+/each)                     $80
Plastic sectioning (each)$72$86$144
Cryo sample sectioning (run) **$125$150$250
Immuno-gold labeling (run) ***
(single/double label)
Grid metal staining (each, 8 minimum)$6$8$12
Negative staining (run, 4 max)$70$84$140
High pressure freezing /Per shot + LN2
Freeze substitution / 1-4 samples$180$216$360
**The charge for cryo-sectioning is for a maximum of 12 grids, additional grids being charged per time.
***Up to 3 antibodies

Services are invoiced monthly after a project is completed.

ServiceYaleOther InstitutionIndustry
Standard TEM / sample$350$420$700
High pressure freezing & freeze-substitution / run$420$504$840
Cryosectioning and immunogold labeling / run$450$540$900

Complete service includes embedding, ultrathin sectioning/cryosectioning, staining / immunogold labeling, observation at the EM, and digital imaging, all carried out by the staff of the facility.

For more information regarding additional services, please contact the facility staff.

Training is invoiced in full once the request has been submitted and approved by the Facility Director, Xinran Liu.

Electron MicroscopeTraining HoursPrepaid HoursYaleOther InstitutionIndustry
FEI Tecnai Biotwin106$1,000$1,200$2,000
FEI Tecnai T12106$1,000$1,200$2,000
FEI Tecnai TF20 TEM/STEM (hourly)

FEI Tecnai F20 Cryo EM (hourly)


Invoicing & Payment


All requests for services and training must be submitted with a valid Yale PTAEO or purchase order from your institution. Please keep in mind that no work can begin prior to receipt of the PTAEO or purchase order - which will be referenced by the Electron Microscopy to invoice your department or institution.

Please note that in some instances a record of estimated charges (quote) has been emailed to you as requested. This quote is not an invoice. Invoices are emailed/mailed monthly and generally within 30 days after the completion of the requested service. All invoice payments should be made upon receipt of the invoice.

Invoicing and Payment Information

Yale Federal Tax Identification Number:


Payments Due:

Upon receipt of Invoice

Mail Payments To:

Yale University

Make Check Payments To:

Yale University School of Medicine
Treasury Operations
P.O. Box 208087
333 Cedar Street, I-100 SHM
New Haven, CT 06520-8087

Invoice or Payment Inquiries:

Please Note

It is VERY IMPORTANT that check information includes a reference that payment is for Electron Microscopy Facility and invoice number (please list invoice number) to ensure the transfer is credited correctly by the Yale Financial Office.


Any questions regarding invoices or payments should be emailed to: