Recent Publications

English DP, Bellone S, Schwab CL, Roque DM, Lopez S, Bortolomai I, Cocco E, Bonazzoli E, Chatterjee S, Ratner E, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Santin AD.
Solitomab, an epithelial cell adhesion molecule/CD3 bispecific antibody (BiTE), is highly active against primary chemotherapy-resistant ovarian cancer cell lines in vitro and fresh tumor cells ex vivo.
Cancer. 2014 Sep 23.

Han L, Zi X, Garmire LX, Wu Y, Weissman SM, Pan X, Fan R.
Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform.
Sci Rep. 2014 Sep 26;4:6485.

Schwab CL, Bellone S, English DP, Roque DM, Lopez S, Cocco E, Nicoletti R, Bortolomai I, Bonazzoli E, Ratner E, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Santin AD.
Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrialcancer in vitro and in vivo.
Br J Cancer. 2014 Sep 30.

Brown TC, Juhlin CC, Healy JM, Prasad ML, Korah R, Carling T.
Frequent Silencing of RASSF1A via Promoter Methylation in Follicular Thyroid Hyperplasia: A Potential Early Epigenetic Susceptibility Event in Thyroid Carcinogenesis.
JAMA Surg. 2014 Sep 17.

Bosenberg MW, Turk MJ. Steinberg SM, Zhang P, Malik B, Boni A, Shabaneh T, Byrne K, Mullins DW, Brinckerhoff CE, Ernstoff M,
BRAF-inhibition alleviates immune suppression in murine autochthonous melanoma.
Cancer Immunol Res. 2014 Sep 2

Honarpisheh H, Camp R, Lazova R.
Staphylococcal Purpura Fulminans: Report of a Case.
Am J Dermatopathol. 2014 Aug 5.

Schwab CL, English DP, Roque DM, Bellone S, Lopez S, Cocco E, Nicoletti R, Rutherford TJ, Schwartz PE, Santin AD.
Neratinib shows efficacy in the treatment of HER2/neu amplified uterine serous carcinoma in vitro and in vivo.
Gynecol Oncol. 2014 Aug 12.

Chen X, Wilson JB, McChesney P, Williams SA, Kwon Y, Longerich S, Marriott AS, Sung P, Jones NJ, Kupfer GM.
The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization.
J Biol Chem. 2014 Jul 28. pii: jbc.M114.552570.

Schimmack S, Taylor A, Lawrence B, Alaimo D, Schmitz-Winnenthal H, Büchler MW, Modlin IM, Kidd M.
A mechanistic role for the chromatin modulator, NAP1L1, in pancreatic neuroendocrine neoplasm proliferation and metastases.
Epigenetics Chromatin. 2014 Jul 21;7:15.

Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE.
Novel gene identified in an exome-wide association study of tanning dependence.
Exp Dermatol. 2014 Jul 16.

Callender GG, Udelsman R.
Surgery for primary hyperparathyroidism.
Cancer. 2014 Jul 9.

Theodosakis N, Micevic G, Kelly DP, Bosenberg M.
Mitochondrial function in melanoma.
Arch Biochem Biophys. 2014 Jul 2.

Pillai MM, Gillen AE, Yamamoto TM, Kline E, Brown J, Flory K, Hesselberth JR, Kabos P.
HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
Breast Cancer Res Treat. 2014 Jun 7.

Zhang B, Bolognia J, Marks P, Podoltsev N.
Enhanced skin toxicity associated with the combination of clofarabine plus cytarabine for the treatment of acute leukemia.
Cancer Chemother Pharmacol.

Menderes G, Azodi M, Clark L, Xu X, Lu L, Ratner E, Schwartz PE, Rutherford TJ, Santin AD, Silasi DA.
Impact of Body Mass Index on Surgical Outcomes and Analysis of Disease Recurrence for Patients With Endometrial Cancer Undergoing Robotic-Assisted Staging.
Int J Gynecol Cancer. 2014 Jun 12.

Higgins Ii HW, Lee KC, Leffell DJ.
Point of care cutaneous imaging technology in melanoma screening and mole mapping.
F1000Prime Rep. 2014 May 6;6:34.

Fenn KM, Evans SB, McCorkle R, DiGiovanna MP, Pusztai L, Sanft T, Hofstatter EW, Killelea BK, Knobf MT, Lannin DR, Abu-Khalaf M, Horowitz NR, Chagpar AB.
Impact of Financial Burden of Cancer on Survivors' Quality of Life?
J Oncol Pract. 2014 May 27.

Santamaria X, Taylor H.
MicroRNA and gynecological reproductive diseases.
Fertil Steril. 2014 Jun;101(6):1545-1551.

English DP, Bellone S, Schwab CL, Bortolomai I, Bonazzoli E, Cocco E, Buza N, Hui P, Lopez S, Ratner E, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Santin AD.
T-DM1, a novel antibody-drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo.
Cancer Med. 2014 Jun 2.

Callender GG, Carling T, Christison-Lagay E, Udelsman R.
Surgery for Thyroid Cancer.
Endocrinol Metab Clin North Am. 2014 Jun;43(2):443-458.

Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S.
SRF is required for neutrophil migration in response to inflammation.
Blood. 2014 Feb 26.

Brierley KL, Bonadies DC, Moyer A, Matloff ET.
Would you test your children without their consent?" and other sticky dilemmas in the field of cancergenetic testing.
Fam Cancer. 2014 May 8.

Semkova K, Lott JP, Lazova R.
Clinicopathologic features and survival in Spitzoid malignant melanoma and conventional malignant melanoma.
J Am Acad Dermatol. 2014 May 15.

Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST.
Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study.
Eur J Cancer Prev. 2014 May 16.

Schalper KA, Velcheti V, Carvajal D, Wimberly H, Brown J, Pusztai L, Rimm DL.
In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas.
Clin Cancer Res. 2014 May 15;20(10):2773-82.

Vasan N, Yelensky R, Wang K, Moulder S, Dzimitrowicz H, Avritscher R, Wang B, Wu Y, Cronin MT, Palmer G, Symmans WF, Miller VA, Stephens P, Pusztai L.
ATargeted Next-Generation Sequencing Assay Detects a High Frequency of Therapeutically Targetable Alterations in Primary and Metastatic Breast Cancers: Implications for Clinical Practice.
Oncologist. 2014 Apr 7.

Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM.
Immune-based antitumor effects of BRAF Inhibitors rely on signaling by CD40L and IFN-γ.
Cancer Res. 2014 Apr 15.

Goh G, Scholl UI, Healy JM, Choi M, Prasad ML, Nelson-Williams C, Kuntsman JW, Korah R, Suttorp AC, Dietrich D, Haase M, Willenberg HS, Stålberg P, Hellman P, Akerström G, Björklund P, Carling T, Lifton RP.
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.
Nat Genet. 2014 Apr 20.

Ustun B, Chhieng D, Van Dyke A, Carling T, Holt E, Udelsman R, Adeniran AJ.
Risk stratification in follicular neoplasm: A cytological assessment using the modified bethesda classification.
Cancer Cytopathol. 2014 Apr 18.

Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q.
Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis.
Cell Rep. 2014 Feb 25.

Schalper KA, Velcheti V, Carvajal D, Wimberly H, Brown J, Pusztai L, Rimm DL.
In situ Tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas.
Clin Cancer Res. 2014 Mar 19. 

Murtha M, Tokcaer-Keskin Z, Tang Z, Strino F, Chen X, Wang Y, Xi X, Basilico C, Brown S, Bonneau R, Kluger Y, Dailey L.
FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells.
Nat Methods. 2014 Mar 23.

Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S.
SRF is required for neutrophil migration in response to inflammation.
Blood. 2014 Feb 26.

Aktas B, Sun H, Yao H, Shi W, Hubbard R, Zhang Y, Jiang T, Ononye SN, Wali VB, Pusztai L, Symmans WF, Hatzis C.
Global gene expression changes induced by prolonged cold ischemic stress and preservation method of breast cancer tissue.
Mol Oncol. 2014 Feb 17.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.
Development and function of human innate immune cells in a humanized mouse model.
Nat Biotechnol. 2014 Mar 16.

Shi W, Balazs B, Györffy B, Jiang T, Symmans WF, Hatzis C, Pusztai L.

Combined Analysis of gene expression, DNA copy number, and mutation profiling data to display biological process anomalies in individual breast cancers. 

Breast Cancer Res Treat. 2014 Mar 12. 

Zhao S, Choi M, Heuck C, Mane S, Barlogie B, Lifton RP, Dhodapkar MV.
Serial exome analysis of disease progression in premalignant gammopathies.
Leukemia. 2014 Feb 5.

Ross RJ, Weiner MM, Lin H.
PIWI proteins and PIWI-interacting RNAs in the soma.
Nature. 2014 Jan 16;505(7483):353-9.

Gibson J, Lacy J, Matloff E, Robert M.
Microsatellite instability testing in colorectal carcinoma: a practical guide.
Clin Gastroenterol Hepatol. 2014 Feb;12(2):171-176.e1.

Stahlhut C, Slack FJ.
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications.
Genome Med. 2013 Dec 30;5(12):111.

Matloff ET, Bonadies DC, Moyer A, Brierley KL.
Erratum to: Changes in Specialists' Perspectives on Cancer Genetic Testing, Prophylactic Surgery and Insurance Discrimination: Then and Now.
J Genet Couns. 2013 Aug 6.

Cao J, Yan Q.
Histone demethylases set the stage for cancer metastasis.
Sci Signal. 2013 Apr 30;6(273):pe15.

Kidd M, Gustafsson B, Modlin IM.
Gastric carcinoids (neuroendocrine neoplasms).
Gastroenterol Clin North Am. 2013 Jun;42(2):381-97.

Kwak M, Mu L, Lu Y, Chen JJ, Wu Y, Brower K, Fan R.
Erratum: single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction.
Front Oncol. 2013 Apr 8;3:78.

Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q.
Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High-throughput Screen.
J Biol Chem. 2013 Feb 13.

Metheetrairut C, Slack FJ.
MicroRNAs in the ionizing radiation response and in radiotherapy.
Curr Opin Genet Dev. 2013 Feb 27. 

Kim YJ, Greer CB, Cecchini KR, Harris LN, Tuck DP, Kim TH.
DAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade.
Oncogene. 2013 Feb 25.

Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q.
Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High-throughput Screen.
J Biol Chem. 2013 Feb 13.

Scholl UI, Lifton RP.
New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5.
Curr Opin Nephrol Hypertens. 2013 Jan 10.

Zhao S, Choi M, Overton JD, Bellone S, Roque DM, Cocco E, Guzzo F, English DP, Varughese J, Gasparrini S, Bortolomai I, Buza N, Hui P, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Carrara L, Pecorelli S, Silasi DA, Ratner E, Azodi M, Schwartz PE, Rutherford TJ, Stiegler AL, Mane S, Boggon TJ, Schlessinger J, Lifton RP, Santin AD.
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.
Proc Natl Acad Sci U S A. 2013 Jan 28.

Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J.
An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response.
Cell Rep. 2012 Oct 17.

Brierley KL, Blouch E, Cogswell W, Homer JP, Pencarinha D, Stanislaw CL, Matloff ET.
Adverse events in cancer genetic testing: medical, ethical, legal, and financial implications.
Cancer J. 2012 Jul;18(4):303-9. 

Matloff ET
From the guest editor: cancer genetic counseling and testing: past, present, and future.
Cancer J. 2012 Jul;18(4):285-6

Cromer MK, Starker LF, Choi M, Udelsman R, Nelson-Williams C, Lifton RP, Carling T.
Identification of Somatic Mutations in Parathyroid Tumors Using Whole-Exome Sequencing.
J Clin Endocrinol Metab. 2012 Jun 27.

Bellone S, Roque D, Cocco E, Gasparrini S, Bortolomai I, Buza N, Abu-Khalaf M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD.
Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy.
Br J Cancer. 2012 Apr 24;106(9):1543-50.

Hanna JA, Wimberly H, Kumar S, Slack F, Agarwal S, Rimm DL.
Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization.
Biotechniques. 2012 Apr;52(4):235-45.

Lo SM, Choi M, Liu J, Jain D, Boot RG, Kallemeijn WW, Aerts JM, Pashankar F, Kupfer GM, Mane S, Lifton RP, Mistry PK.
Phenotypic diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematological malignancy phenotype by individual genome analysis.
Blood. 2012 Apr 4.

Cao J and Yan
Q  Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.
Front. Oncol. 2:26. doi: 10.3389/fonc.2012.00026 

Kundu ST, Nallur S, Paranjape T, Boeke M, Weidhaas JB, Slack FJ.
KRAS alleles: The LCS6 3'UTR variant and KRAS coding sequence mutations in the NCI-60 panel.
Cell Cycle. 2012 Jan 15;11(2).

Russ R, Slack FJ.
Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis
Pulm Med. 2012;2012:791234. Epub 2011 Dec 1.

Kasinski AL, Slack FJ.
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy.
Nat Rev Cancer. 2011 Nov 24;11(12):849-64.

DA, Slack FJ.
MicroRNAs in Mutagenesis, Genomic Instability, and DNA Repair.
Semin Oncol. 2011 Dec;38(6):743-51

Weidhaas JB, Slack FJ.
KRAS rs61764370 in Epithelial Ovarian Cancer-Letter.
Clin Cancer Res. 2011 Oct 15;17(20):6600.

Babar IA Czochor J, Steinmetz A. Weidhaas JB. Glazer PM, Slack FJ.
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells.
Cancer Biol Ther. 2011 Nove 15;12(10)

Kluger, H.M., Hoyt, K., Bacchiocchi, A., Mayer, T., Kirsch, J., Kluger, Y., Sznol, M., Ariyan, S., Molinaro, A., Halaban, R.
Plasma markers for identifying patients with metastatic melanoma
(2011) Clinical Cancer Research, 17 (8), pp. 2417-2425.

Paranjape, T., Heneghan, H., Lindner, R., Keane, F.K., Hoffman, A., Hollestelle, A., Dorairaj, J., Geyda, K., Pelletier, C., Nallur, S., Martens, J.W.M., Hooning, M.J., Kerin, M., Zelterman, D., Zhu, Y., Tuck, D., Harris, L., Miller, N., Slack, F., Weidhaas, J.
A 3'-untranslated region KRAS variant and triple-negative breast cancer: A case-control and genetic analysis
(2011) The Lancet Oncology, 12 (4), pp. 377-386.

Godshalk, S.E., Paranjape, T., Nallur, S., Speed, W., Chan, E., Molinaro, A.M., Bacchiocchi, A., Hoyt, K., Tworkoski, K., Stern, D.F., Sznol, M., Ariyan, S., Lazova, R., Halaban, R., Kidd, K.K., Weidhaas, J.B., Slack, F.J.
A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma
(2011) Oncogene, 30 (13), pp. 1542-1550. Cited 1 time.

Starker, L.F., Delgado-Verdugo, A., Udelsman, R., Björklund, P., Carling, T.
Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism
(2010) Endocrine, 38 (3), pp. 397-401.