Daniel P Petrylak, MD

Professor of Medicine (Medical Oncology) and of Urology; Co-Director, Signal Transduction Research Program

Departments & Organizations

Cancer Center, Yale: Prostate and Urologic Cancers Program | Signal Transduction

General Urology

Medical Oncology: Subset Medical Oncology Faculty

Medical Oncology

Office of Student Research

Yale Medical Group


As Professor of Medicine and Urology at Yale School of Medicine, Dr. Daniel P. Petrylak is a pioneer in the research and development of new drugs and treatments to fight prostate, bladder, kidney and testicular cancer. For patients fighting these types of cancers, Petrylak finds recent developments in the field of immunotherapy particularly promising. “Up until recently, bladder cancer had not seen any major advancement in more than 30 years,” he says. “Studies are ongoing, but interim results are exciting so far.”

At the Smilow Cancer Hospital, Dr. Petrylak’s position as a national leader on clinical trials for men with prostate and bladder cancer has opened up a world of treatment options for patients in New England. “We offer the latest investigational drugs for these conditions, while providing the highest level of care,” he says.

Dr. Petrylak received his MD from Case Western Reserve University School of Medicine and joined the Yale faculty in 2012. In addition to his role as professor, he is also the co-director of the Signal Transduction Research Program at Yale Cancer Center, which studies how cancer stem cells are regulated in the body and communicate with surrounding tissue. Roughly 40 physicians and scientists in the program work together to develop the best methods for matching patients with the appropriate cancer drugs.

One of Dr. Petrylak’s key goals is to continue to successfully translate basic research into clinical practice. “One of the most significant accomplishments in my career was moving docetaxel (an antineoplastic agent) therapy for the most advanced form of prostate cancer from phase I to III,” he says. “We ran a trial which supported its approval for the most advanced form of prostate cancer.”

Dr. Petrylak currently serves as either the principal investigator or co-principal investigator on seven Southwest Oncology Group (SWOG) clinical trials for genitourinary cancers. To date, he has authored more than 100 peer-reviewed articles on prostate and bladder cancer research.

Education & Training

MD Case Western Reserve University School of Medicine (1985)
Fellowship Memorial Sloan-Kettering Cancer Center
Residency Bronx Municipal Hospital
Internship Bronx Municipal Hospital
Board Certification AB of Internal Medicine, Medical Oncology (1993)

Edit this profile

Contact Info

Daniel P Petrylak, MD
Patient Care Location
Smilow Cancer Hospital at Yale-New HavenYale-New Haven Hospital
20 York Street, Ste North Pavilion 4

New Haven, CT 06510
Mailing Address
PO Box 208032
New Haven, CT 06520-8032

Curriculum Vitae