Brian Richard Smith MD

Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics; Chair, Department of Laboratory Medicine, Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics

Research Interests

Inflammation-Coagulation Interface; Hematology; Bioethics; Biomedical Engineering; Laboratory Medicine Education; Therapeutic Pathology

Research Summary

Dr. Smith's research laboratory primarily investigates the inflammation-coagulation interface, especially at the cellular level, i.e., the interaction of leukocytes and platelets, but also at the level of soluble mediators such as the complement system. A major interest is in relating basic biological events to human disease, for example, studying the mechanisms and consequences of platelet, leukocyte and complement activation during cardiac surgery, as a consequence of transfusion, in the pathophysiology of tumor metastasis, and in primary hematologic disorders. Because of the importance of inflammation-coagulation in the success or failure of clinically utilized biomechanical devices, the laboratory is also engaged in aspects of biomedical engineering.

In addition to these areas, Dr. Smith is involved in clinically oriented research designed to improve hematologic and immunologic diagnostics and ''personalized'' cell therapy, has published in the area of bioethics, and is engaged in educational methodology research to improve medical student education in Laboratory Medicine.

Selected Publications

  • Truong F, Smith, BR, Stachurski D, Cerny J, Medeiros LJ, Woda BA, Wang SA. The Utility of Flow Cytometric Immunophenotyping in Cytopenic Patients with a Non-Diagnostic Bone Marrow- A Prospective Study. 2009. Leuk Res 33: 1039-46.
  • Smith BR. Therapeutic Pathology: Time to Move Beyond Diagnostics. 2008. Hum Pathol 39: 1725-7.
  • Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation. Ann Thorac Surg. 2007 Jan83(1):146-52.
  • Greilich PE, Brouse CF, Rinder HM, Jessen ME, Rinder CS, Whitten CW, Eberhart RC, Smith BR. 2008. Differential markers and time course of monocyte activation in on- versus off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesthes 22: 361-8.
  • Rinder CS, Rinder HM, Smith MJ, Fitch JCK, Tracey JB, Chandler WL, Rollins SA, Smith BR. 2006. Antithrombin reduces monocyte and neutrophil CD11b upregulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 46(7): 1130-1137.
  • Smith BR, Rinder HM, Rinder CS. 2006. Chapter 59: Cardiopulmonary Bypass. In: Michaelson, A (ed) Platelets, 2nd Edition (Academic Press, New York) pp. 1077-1095.

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