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Anna Marie Pyle

William Edward Gilbert Prof of Molecular, Cellular & Developmental Biology; Director, Division of Biological Sciences

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Computational Biology and Bioinformatics | Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Molecular, Cellular, and Developmental Biology

Molecular Virology

Structural Biology

Center for RNA Science and Medicine, Yale

RNA Biology

Structural Biology

Mechanisms of Viral Pathogenesis

Molecular Virology


Research Interests

Structure and function of catalytic RNA; RNA helicase mechanisms; Computational analysis of RNA structure  more...


Selected Publications

  • Dumont, S., et al. (2006). RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature 439:105-108.
  • Solem, A., Zingler, N., and Pyle, A.M. (2006). A DEAD protein that activates intron self-splicing without unwinding RNA. Mol. Cell 24:611-617.
  • Toor, N., Keating, K. S., Taylor, S. D. and Pyle, A. M. Crystal structure of a self-spliced group II intron. Science 320, 77-82 (2008)

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