Alanna Schepartz, PhD

Milton Harris Professor of Chemistry; Professor of Molecular, Cellular, & Developmental Biology

Research Interests

Biochemistry; Biology; Chemistry; Cell Biology; Diseases; Chemicals and Drugs; Health Care

Research Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS)

Cancer Center, Yale: Developmental Therapeutics

Chemical Biology Institute

Office of Cooperative Research

Research Summary

The Schepartz laboratory applies the tools of chemistry, cell biology, biochemistry, and molecular imaging to study and manipulate protein networks and assemblies inside the cell. Our approach centers on the design and synthesis of molecules–miniature proteins, ß-peptides, fluorolipids, and designer fluorophores–that, by virtue of their structure or function, probe the functional roles of protein interactions or networks in the native cellular or organismal environment. Current topics include the design of miniature protein catalysts that rewire cellular circuits, the application of cell-permeable designer fluorophores to characterize transmembrane information transfer, the synthesis and application of orthogonal cellular compartments, and the design of protein-like assemblies of ß-peptides that possess catalytic function. For more information, please visit our group web site

Specialized Terms: Organic chemistry; chemical biology; biosynthetic engineering; drug design; synthetic biology; Novel methods to inhibit HIV infection

Extensive Research Description

Our research group is large and we investigate a broad range of scientific questions at the combined interface of chemistry, biology, and medicine. A subset of these projects is listed below.
1. Design and application of a cell signaling node to reactivate p53.
2. Genomic, high contact analysis of peptidomimetic release from early endosomes.
3. Illuminating cconformational changes controlling ligand-specific activation of EGFR family members.
4. Design and synthesis of a beta-peptide catalyst for the synthesis and cleavage of glycosidic bonds.
5. Design of b-peptide agonists of class B GPCRs.
6. Design and application of fluorolipid-based orthogonal cellular compartments.

Selected Publications

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