Examination of Epigenetic Changes in Breast Tissue and Peripheral Blood of Women at Average versus Increased Risk of Breast Cancer
Trial Purpose and Description
This study will test the hypothesis that epigenetic alterations in DNA accumulate more rapidly in the breast during the lifetime of women who are at increased risk for breast cancer compared to those who are at average risk. The objective is to compare the type and rate of epigenetic changes that accumulate in the breasts and/or blood of a cohort of women at increased risk of breast cancer with a cohort of age-matched women at average risk.
- 18 Years and older
- Undergoing mastectomy for Stage 0-III breast cancer.
- Data that will be collected: Hx DCIS or LCIS Hx Breast Atypical Hyperplasia FH breast cancer Known carrier of BRCA 1 or 2 mutation, or other known germline cancer predisposing mutation Active HRT Past HRT use and prior chest XRT.
- Women >18 years.
- Received neoadjuvant chemotherapy or hormonal therapy
- Lion Heart Fund for Cancer Research
- Last Updated:
- Study HIC#: