test

Examination of Epigenetic Changes in Breast Tissue and Peripheral Blood of Women at Average versus Increased Risk of Breast Cancer

Conditions

Breast Cancer | Cancer

Trial Phase

Trial Purpose and Description

Trial Purpose

This study will test the hypothesis that epigenetic alterations in DNA accumulate more rapidly in the breast during the lifetime of women who are at increased risk for breast cancer compared to those who are at average risk. The objective is to compare the type and rate of epigenetic changes that accumulate in the breasts and/or blood of a cohort of women at increased risk of breast cancer with a cohort of age-matched women at average risk.


Participation Guidelines

Age:
18 Years and older
Gender:
Female

Eligibility Criteria

Inclusion Criteria:

  • Undergoing mastectomy for Stage 0-III breast cancer.
  • Data that will be collected: Hx DCIS or LCIS Hx Breast Atypical Hyperplasia FH breast cancer Known carrier of BRCA 1 or 2 mutation, or other known germline cancer predisposing mutation Active HRT Past HRT use and prior chest XRT.
  • Women >18 years.

Exclusion Criteria:

  • Received neoadjuvant chemotherapy or hormonal therapy

Sponsor:
Terri Brodeur Breast Cancer Foundation
Dates:
11/07/2013
Last Updated:
Study HIC#:
1302011482