Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer


Endometrial Clear Cell Carcinoma | Endometrial Papillary Serous Carcinoma | Stage I Endometrial Carcinoma | Stage II Endometrial Carcinoma | Stage III Endometrial Carcinoma | Stage IV Endometrial Carcinoma

What is the purpose of this trial?

This randomized phase III trial studies carboplatin and paclitaxel to see how well they work with or without cisplatin and radiation therapy in treating patients with stage I, stage II, stage III, or stage IVA endometrial cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Giving chemotherapy and radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether carboplatin and paclitaxel are more effective with or without cisplatin and radiation therapy in treating patients with endometrial cancer.

Participation Guidelines

18 Years - N/A

Click here for detailed information about who can participate in this trial.

Gynecologic Oncology Group
National Cancer Institute (NCI)
June 2009
Last Updated:
August 6, 2014
Study HIC#:

Clinicaltrials.gov ID: NCT00942357