Murat Gunel MD, FACS, FAHA

Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neurobiology; Co-Director, Yale Program on Neurogenetics; Director, Neurovascular Surgery

Departments & Organizations

Gamma Knife Center, Yale-New Haven

Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Cell Biology, Genetics and Development

Interdepartmental Neuroscience Program

Yale Medical Group

Cancer Center, Yale

Vascular Biology and Therapeutics Program

Neurobiology

Genetics

Neurosurgery: Neurovascular Surgery | Brain Aneurysm & AVM Program

Brain Tumor Research

Research Interests

Molecular genetics and biology of brain aneurysms and cavernous malformations; molecular genetics of brain development more...

Education

• M.D., Istanbul University, 1991

Selected Publications

• Bilgüvar K, Öztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoglu D, Tüysüz B, Çaglayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioglu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MJ, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandas S, Topçu M, Özmen M, Šestan N, Lifton RP, State MW, Günel M: Whole exome sequencing identifies recessive mutations in severe brain malformations, Nature, 467(7312):207-10, 2010.
• Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok YM, Niemela M, Tajima A, von und zu Fraunberg M, Doczi T, Wirjatijasa F, Hata A, Blasco J, Oszvald A, Kasuya H, Zilani G, Schoch B, Singh P, Stüer C, Risselada R, Beck J, Sola T, Ricciardi F, Aromaa A, Illig T, Schreiber S, van Duijn CM, van den Berg LH, Perret C, Proust C, Roder C, Ozturk AK, Gaál E, Berg D, Geisen C, Friedrich CM, Summers P, Frangi AF, State MW, Wichmann HE, Breteler MMB, Wijmenga C, Mane S, Peltonen L, Elio V, Sturkenboom MCJM, Lawford P, Byrne J, Macho J, Sandalcioglu EI, Meyer B, Raabe A, Steinmetz H, Rüfenacht D, Jääskeläinen JE, Hernesniemi J, Rinkel GJE, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Günel M: Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42(5):420-5, 2010.
• He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W: Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal. 2010 Apr 6;3(116):ra26

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