Christos Hatzis Ph.D.
Assistant Professor of Medicine (Medical Oncology); Director, Bioinformatics, Breast Medical Oncology at Yale Cancer Center
Personalized medicine; Molecular diagnostics; Cancer heterogeneity; Next generation sequencing; Diagnostic study design
Characterization of molecular and genetic heterogeneity in breast cancer and its association with treatment response or resistance.
Evaluation of high-throughput drug screens for triple negative breast cancer and assocation of sensitivity to genetic background.
Translation of microarray based prognostic tests to next generation platforms.
Dr. Hatzis continues to be involved in the design of biomarker validation clinical studies and development of strategies for translating genomic diagnostic assays to clinical practice. His current research interests focus on developing methods to characterize the genetic and molecular heterogeneity of breast cancer subtypes and the implications it might have on response and resistance to treatment. A key area of interest is to develop methodology that integrates genomic level information of individual patients to lead to more focused treatment decisions tailored for the individual tumor.