| Grand Rounds
I was very pleased with the successful turnout at our first Grand Rounds of the year on Tuesday. I hope that you all enjoyed the new format for Rounds and that you will continue to fill the room each week. We will continue to hold Rounds in Brady Auditorium for the remainder of September and will evaluate attendance and determine if we should move to a larger space at that time. Additional lunches will be ordered to accommodate the increased attendance.
Please join me on Tuesday, September 22nd to listen to presentations by Francine Foss, MD and Melinda Irwin, PhD.
Learn More >>
Yale Cancer Center Welcomes Don Xuan Nguyen, PhD
We are pleased to announce that Don Nguyen will join the faculty of the Department of Pathology at Yale School of Medicine as an Assistant Professor. In his new role, Dr. Nguyen will be an active member of Yale Cancer Center.
In his current position, he is a postdoctoral fellow with Joan Massague at Memorial Sloan-Kettering Cancer Institute. Dr. Nguyen will continue his postdoctoral work, in which he has pioneered models to identify genes most important for human lung cancer metastasis. This work will help found two important new areas of research in YCC, the biology of tumor progression, and etiology and treatment of thoracic cancers.
Faculty Profiles The Yale School of Medicine Office of Institutional Planning and Communications is currently redesigning all of the faculty profile pages. Please take the time to edit the information on your profile to ensure it is both correct and complete. The new profiles will be used to populate all of the department websites, as well as Yale Cancer Center's site.
Learn More >>
|
Smilow Update
As construction nears completion in the Lower Level for Radiation Oncology, functional units are finalizing their departmental operating plans. The Education & Orientation team is completing scripting for tours and orientation sessions, which will begin shortly. Construction workers are now completing the lobby, including finishing the floors, placing the lobby furniture, and installing a water feature.
|
Notables
Matthew Strout, MD, PhD, has been awarded a K08 Career Development Award from the NCI. His research is focused on understanding the basic mechanism that regulates immune diversification in mature B cells and how it breaks down during pathogenesis of B cell leukemia and lymphomas. The total direct costs for the 5-year project period is $817,500.
|
New Clinical Trial Available
HIC 0906005239
Principal Investigator: Madhav Dhodapkar, MD
A Phase I/II Open-Label, Dose-Escalation Study of CDX-1401 in Patients with Malignancies Expressing NY-ESO-1
|
Update from Yale Pathology
Thus, as the Cancer Center increases its role and participation in multi-site clinical trials, it has become important to provide patient tissue samples for these trials. Many trials include signed patient consent for release of this material, but this was in conflict with compliance issues that require that the Department of Pathology maintain tissue blocks for 10 years. To respond to this need and mitigate this conflict, the Department of Pathology has established a new Standard Operating Procedure to provide tissue from formalin fixed, paraffin embedded tissue blocks. The tissue provided is a 4mm core, which is sufficient to meet most clinical trial tissue requirements, but allows maintenance of the block in the Pathology Archives for patient safety and to meet regulatory standards.
For more information, or to place a request, please contact Rose Piche.
If you have questions or concerns about the new procedures and services, please contact David Rimm, MD, PhD.
Learn More >>
|
Shared Resource Highlight
Microarray Shared Resource (MSR)
Major services of the MSR consist of gene expression and genotyping analysis using multiple platforms including Affymetrix, Illumina, NimbleGen, Sequenom, and ABI 7900. In addition to this, the MSR also provides high throughput DNA sequence analysis services using Illumina genome analyzer. The MSR assists in planning and carrying out microarray experiments; expression analysis services that include RNA/mRNA extraction, preparation of target samples suitable for array hybridization, and data analysis; SNP analysis using both Affymetrix (10,100 and 500 K assays) and ABI platforms; and quantitative PCR validation of microarray results using the ABI 7900 Sequence Detection System. The MSR also offers a range of spotted glass slide microarray services.
Shrikant Mane, PhD, Director
(203) 737-2229
Learn More >>
|
Recent Publications
Costs Associated with Capecitabine or 5-Fluorouracil Monotherapy after Surgical Resection in Patients with Colorectal Cancer.
Chu E, Shi N, Wei W, Bendell JC, Cartwright T.
Oncology. 2009 Sep 7;77(3-4):244-253.
Read More >>
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Strout MP, Schatz DG.
Cancer Cell. 2009 Sep 8;16(3):174-6.
Read More >>
C-Raf Is Associated with Disease Progression and Cell Proliferation in a Subset of Melanomas.
Jilaveanu LB, Zito CR, Aziz SA, Conrad PJ, Schmitz JC, Sznol M, Camp RL, Rimm DL, Kluger HM.
Clin Cancer Res. 2009 Sep 8.
Read More >>
Glutathione S-transferase polymorphisms and survival in African-American and White colorectal cancer patients.
Jones BA, Christensen AR, Wise JP Sr, Yu H.
Cancer Epidemiol. 2009 Sep 11.
Read More >>
7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: A novel compound capable of inducing cell death in epithelial ovarian cancer stem cells.
Green JM, Alvero AB, Kohen F, Mor G.
Cancer Biol Ther. 2009 Sep 17;8(18).
Read More >>
|
| |
| Inside Yale Cancer Center
Yale Cancer Center Grand Rounds
Video presentations from Yale Cancer Center members are now available online.
Learn More >>
Novel "On-Off Switch" Mechanism Stops Cancer in Its Tracks
Prostate Cancer Symposium
Share the invite to our annual prostate cancer symposium with your patients.
|
Events
September 21; 12:00 PM
Schwartz Center Rounds
YNHH EP 9th Fl. Conference Rm
Disagreeing with your Attending
September 22; 9:30 AMYale Cancer Center Seminar
WWW 201Racial Disparities in Cancer CareChristopher Lathan, MD, MPH
September 22; 12:00 PM
Yale Cancer Center Grand Rounds
Brady Auditorium
T-Cell Lymphomas: Assessing the Knowledge Gap Francine Foss, MD
Physical Activity and Cancer Prognosis and Survivorship Melinda Irwin, PhD
Learn More >>
September 26; 6:00 PM
Understanding Cancer Lecture
YNHH East Pavilion Cafeteria
Cancer: Is it Hereditary in my Family?
Rachel Barnett, MS
September 27; 6:00 PM Yale Cancer Center Answers
WNPR 90.5 FM Prostate Cancer
Wm. Kevin Kelly, DO
Learn More >>
|
Submissions
Please submit your recent publication and grant announcements to:
Renee Gaudette
Director, Public Affairs and Marketing
renee.gaudette@yale.edu
|
|
|
