Selected References

2008

• DE Befroy, KF Petersen, S Dufour, GF Mason, DL Rothman and GI Shulman. Increased Substrate Oxidation and Mitochondrial Uncoupling in Skeletal Muscle of Endurance Trained Individuals. Proc Natl Acad Sci USA 105:16701-16706, 2008. PMID: 18936488.
• DE Befroy, CS Choi, R Codella, S Kim, RM Reznick, YJ Hwang, ZX Liu, HY Lee, A Distefano, VT Samuel, D Zhang, GW Cline, C Handschin, J Lin, KF Petersen, BM Spiegelman, GI Shulman. Paradoxical Effects of Increased Expression of PGC-1 on Muscle Mitochondrial Function and Insulin Stimulated Muscle Glucose Metabolism. Proc Natl Acad Sci USA. in press, 2008.
• DM Wigmore, DE Befroy, IR Lanza, JA Kent-Braun. Contraction frequency modulates muscle fatigue and intracellular oxygenation during incremental contractions in humans. App Phys Nutr Metab, 3: 915-921, 2008., PMID: 18923566
• Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psych. 2008 Sep 30. [Epub ahead of print]
• Chahboune H, Mahdjoub R, Desgoutte P, Rousset C, Briguet A, Cespuglio R. Effects of chloramphenicol on brain energy metabolism using (31)P spectroscopy: influences on sleep-wake states in rat. Journal of neurochemistry, 106(4):1552-62, 2008.
• d'Errico F, Di Fulvio A, Maryanski M, Selici S. and Torrigiani M. Optical readout of superheated emulsions. Radiat. Meas 43(2-6) 432-436 (2008).
• T. W. Nixon, S. McIntyre, D. L. Rothman, R. A. de Graaf, Compensation of gradient-induced magnetic field perturbations, J. Magn. Reson. 192, 209-217 (2008).
• R. A. de Graaf, P. B. Brown, D. L. Rothman, K. L. Behar, Natural abundance 17O NMR spectroscopy of rat brain in vivo, J. Magn. Reson. 193, 63-67 (2008).
• Sanganahalli BG, Herman P, Hyder F.(2008) Frequency-dependent tactile responses in rat brain measured by functional MRI. NMR Biomed. 21(4):410-416.
• Shulman RG, Rothman DL, Hyder F (2007) A BOLD search for baseline. NeuroImage. 36:277-281
• Riera JJ, Schousboe A, Waagepetersen HS, Howarth C, Hyder F (2008) The micro-architecture of the cerebral cortex: Functional neuroimaging models and metabolism. Neuroimage. 40:1436-1459.
• Sanganahalli BG, Herman P, Hyder F (2008) Frequency-dependent tactile responses in rat brain by fMRI. NMR Biomed. 21:410-416.
• Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H (2008) Negative BOLD with large increases in neuronal activity. Cereb Cortex. 18:1814-1827.
• Hyder F (2008) Dynamic imaging of brain function. Methods Mol Med. 489:3-21.
• Sanganahalli BG, Bailey CJ, Herman P, Hyder F (2008) Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents. Methods Mol Med. 489:213-242.
• Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, Blumenfeld H (2008) Remote effects of focal hippocampal seizures on the rat neocortex. J Neurosci. 28:9066-9081.
• Herman P, Sanganahalli BG, Hyder F (2008) Multi-modal measurements of blood plasma and red blood cell volumes during functional brain activation. J Cereb Blood Flow Metab. (in press)
• Coman D, Trübel HK, Rycyna RE, Hyder F (2008) Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent. NMR Biomed. (in press)
• De Feyter HM, Lenaers E, Houten SM, Schrauwen P, Hesselink MK, Wanders RJA, Nicolay K, Prompers JJ: Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. In FASEB Journal, 2008, Epub ahead of print.
• De Feyter HM, Van Den Broek N, Praet SF, Nicolay K, van Loon LJ, Prompers J: Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction. In European Journal of Endocrinology, 2008, p. 643-653.
• Daniel Coman, Hubert K. Trubel, Robert E. Rycyna, Fahmeed Hyder. Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent. (NMR in Biomed., in press)
• Du, H.Y.; Wang, J.; Watzl, J.; Zhang, X.Y. and Hu, Z.D., Classification structure activity relationship (CSAR) studies for prediction of genotoxicity of thiophene derivatives. Toxicology Letters 177(1): 10-19, 2008.
• Du, H.Y.; Zhang, X.Y.; Wang, J.; Yao, X.J and Hu, Z.D., Novel approaches to predict the retention of histidine-containing peptides in immobilized metal-affinity chromatography. Proteomics 8(11): 2185-2195, 2008.

2007

• DE Befroy, KF Petersen, S Dufour, GF Mason, RA de Graaf, DL Rothman and GI Shulman. Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients. Diabetes 56:1376-1381, 2007. PMID: 17287462
• Chowdhury GM, Gupta M, Gibson KM, Patel AB, Behar KL. Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling. J Neurochem. 2007 Dec;103(5):2077-91. Epub 2007 Sep 13.
• Chowdhury GM, Patel AB, Mason GF, Rothman DL, Behar KL. Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development. J Cereb Blood Flow Metab. 2007 Dec;27(12):1895-907. Epub 2007 Apr 18.
• Chahboune H, Ment LR, Stewart WB, Ma X, Rothman DL, Hyder. Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging, NMR in biomedicine, 20 (3), 375-82, 2007.
• R. A. de Graaf, D. L. Rothman, K. L. Behar, High resolution NMR spectroscopy of rat brain in vivo through indirect zero-quantum-coherence detection, J. Magn. Reson. 187, 320-326 (2007).
• Q. Qin, M. Does, J. C. Gore, R. A. de Graaf, 2D arbitrary shape selective excitation summed spectroscopy (ASSESS), Magn. Reson. Med. 58, 19-26 (2007).
• Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F.(2007) Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci U S A. 104(51):20546-20551.
• Maandag NJG, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F (2007) Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci USA. 104:20546-20551
• Juchem C, Logothetis NK, Pfeuffer J. 1H MR Spectroscopy of the Macaque Primary Visual Cortex at 7 Tesla: Strategies and Pitfalls of Shimming at the Brain Surface. Magn Reson Imaging 25, 902-912, 2007.
• Mason GF, Petersen KF, de Graaf RA, Shulman GI, Rothman DL (2007) Measurements of the anaplerotic rate in the human cerebral cortex using 13C MRS and [1-13C] and [2-13C]glucose. J Neurochem 100: 73-86.
• Natasja J.G. Maandag, Daniel Coman, Basavaraju G. Sanganahalli, Peter Herman, Arien J. Smith, Hal Blumenfeld, Robert G. Shulman, Fahmeed Hyder. Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci USA., 2007, Dec 18; 104(51): 20546-20551.
• De Feyter HM, Praet SF, van den Broek NM, Kuipers H, Stehouwer CD, Nicolay K, Prompers JJ, van Loon LJ: Exercise training improves glycemic control in long-standing insulin-treated type 2 diabetic patients. In Diabetes Care, 2007, p. 2511-2513.
• van den Broek NMA, De Feyter HM, de Graaf RA, Nicolay K, Prompers JJ: Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates. In Am J Physiol Cell Physiol, 2007, p. 228-237.
• Wang, J.; Du, H.Y.; Liu, H.X.; Yao, X.J.; Hu, Z.D. and Fan, B.T., Prediction of surface tension for common compounds based on novel methods using heuristic method and support vector machine. Talanta 73: 147-156, 2007.
• Wang, J.; Du, H.Y.; Yao, X.J. and Hu, Z.D., Using classification structure pharmacokinetic relationship (SCPR) method to predict drug bioavailability based on grid-search support vector machine. Analytica Chimica Acta 601(2): 156-163, 2007.

2006

• IR Lanza, DM Wigmore, DE Befroy and JA Kent-Braun. In-vivo ATP Production during free-flow and ischemic muscle contractions in humans. J Physiol. 577:353-367, 2006. PMID: 16945975
• KF Petersen, S Dufour, Jing Feng, D Befroy, J Dziura, CD Man, C Cobelli and GI Shulman. Increased Prevalence of Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Asian Indian Men. Proc. Natl. Acad. Sci. U S A. 103:18273-18277, 2006. PMID: 17114290
• Patel AB, de Graaf RA, Martin DL, Battaglioli G, Behar KL. Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo. J Neurochem. 2006 Apr;97(2):385-96. Epub 2006 Mar 15.
• Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG. Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. J Cereb Blood Flow Metab. 2006 Jul;26(7):865-77. Epub 2006 Jan 11.
• d'Errico, F. Status of radiation detection with superheated emulsions Radiat Prot Dosimetry, 120, 475 - 479 (2006).
• K. M. Koch, S. McIntyre, T. W. Nixon, D. L. Rothman, R. A. de Graaf, Dynamic shim updating on the human brain, J. Magn. Reson. 180, 286-296 (2006).
• K. M. Koch, P. B. Brown, D. L. Rothman, R. A. de Graaf, Sample-specific diamagnetic and paramagnetic passive shimming, J. Magn. Reson. 182, 66-74 (2006).
• Kocsis L, Herman P, Eke A. (2006) Mathematical model for the estimation of hemodynamic and oxygenation variables by tissue spectroscopy. J Theor Biol. 241(2):262-275.
• Herman P, Eke A. (2006) Nonlinear analysis of blood cell flux fluctuations in the rat brain cortex during stepwise hypotension challenge. J Cereb Blood Flow Metab. 26(9):1189-1197.
• Eke A, Herman P, Hajnal M. (2006) Fractal and noisy CBV dynamics in humans: influence of age and gender. J Cereb Blood Flow Metab. 26(7):891-898.
• Herman P, Trubel HK, Hyder F. (2006) A multiparametric assessment of oxygen efflux from the brain.J Cereb Blood Flow Metab. 26:79-91.
• Juchem C, Muller-Bierl B, Schick F, Logothetis NK, Pfeuffer J. Combined Passive and Active Shimming for In Vivo MR Spectroscopy at High Magnetic Fields. J Magn Reson 183, 278-289, 2006.
• Schmid MC, Oeltermann A, Juchem C, Smirnakis SM, Logothetis NK. Simultaneous EEG and fMRI in the macaque monkey at 4.7 T. Magn Reson Imaging 24(4), 335-342, 2006.
• Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI (2006) Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 55: 929-934.
• Mason GF, Petrakis IL, de Graaf RA, Appel M, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL, Krystal JH (2006) Cortical GABA Levels and the Recovery from Alcohol Dependence: Preliminary Evidence of Modification by Cigarette Smoking. Biol Psychiatry 59: 85:93.
• Praet SF, De Feyter HM, Jonkers RA, Nicolay K, Pul C, Kuipers H, Loon LJ, Prompers JJ: (31)P MR spectroscopy and in vitro markers of oxidative capacity in type 2 diabetes patients. In Magn Reson Mater Phy, 2006, p. 321-331.
• De Feyter HM, Schaart G, Hesselink MK, Schrauwen P, Nicolay K, Prompers JJ: Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle. In Magnetic Resonance in Medicine, 2006, p. 19-25.

2005

• IR Lanza, DE Befroy and JA Kent-Braun. Age-related changes in ATP-producing pathways in human skeletal muscle in-vivo. J. Appl. Phys. 99: 1736-1744, 2005. PMID: 16002769
• KF Petersen, S Dufour, D Befroy, M Lehrke, RE Hendler and GI Shulman. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes. 54: 603-8, 2005. PMID: 15734833
• Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL. The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. Proc Natl Acad Sci USA. 2005 Apr 12;102(15):5588-93. Epub 2005 Apr 4.
• R. A. de Graaf, Theoretical and experimental evaluation of broadband decoupling techniques for in vivo NMR spectroscopy, Magn. Reson. Med. 53, 1297-1306 (2005).
• Juchem C, Logothetis NK, Pfeuffer J. High-resolution (1)H chemical shift imaging in the monkey visual cortex. Magn Reson Med 54(6), 1541-6, 2005.
• Daniel Coman and Irina M. Russu. A Nuclear Magnetic Resonance Investigation of the Energetics of Base Pair Opening Pathways in DNA. Biophys J., 2005, 89(5):3285-3292.
• Daniel Coman and Irina M. Russu. Base-pair opening in three DNA-unwinding elements. Journal of Biological Chemistry, 2005, 280(21): 20216-20221.

2004

• KF Petersen, S Dufour, D Befroy, Rina Reyes and GI Shulman. Impaired mitochondrial activity in insulin-resistant offspring of Type 2 diabetics. N. Engl. J. Med. 350: 664-671, 2004. PMID: 14960743
• Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, Behar KL. Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation. J Cereb Blood Flow Metab. 2004 Sep;24(9):972-85.
• Shulman RG, Rothman DL, Behar KL, Hyder F. Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci. 2004 Aug;27(8):489-95. Review.
• B Sorli, J F Chateaux, H Chahboune, B Favre, A Briguet and P Morin. Micro-spectrometer for NMR: analysis of small quantities in vitro, Measurments Science and Technology, 15, 877-880, 2004.
• R. A. de Graaf, G. F. Mason, A. B. Patel, D. L. Rothman, K. L. Behar, Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo, Proc. Natl. Acad. Sci. USA 101, 12700-12705 (2004).
• Trubel H, Herman P, Kampmann C, Huth R, Maciejewski PK, Novotny E, Hyder F. (2004) A novel approach for selective brain cooling: implications for hypercapnia and seizure activity. Intensive Care Med 30:1829-1833.

2003

• KF Petersen, D Befroy, S Dufour, J Dzuira, C Ariyan, DL Rothman, L DiPietro, GW Cline and GI Shulman. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science. 300:1140-1142, 2003. PMID: 12750520
• d'Errico, F., Prokofiev, A., Sannikov, A.V., Schuhmacher, H. High-energy neutron detection and spectrometry with superheated emulsions. Nucl. Instr. Methods. A 505(1-2) 50-53 (2003).
• Mason GF, Petersen KF, de Graaf RA, Kanamatsu T, Otsuki T, Shulman GI, Rothman DL (2003) A Comparison of 13C NMR Measurements of the Rates of Glutamine Synthesis and the Tricarboxylic Acid Cycle During Oral and Intravenous Administration of [1-13C]Glucose. Brain Res Protocols 10: 181-190.
• Daniel Coman and Irina M. Russu. Probing hydrogen bonding in a DNA triple helix using protium-deuterium fractionation factors. Journal of the American Chemical Society, 2003, 125(22): 6626-6627.

2002

• Sepkuty JP, Cohen AS, Eccles C, Rafiq A, Behar K, Ganel R, Coulter DA, Rothstein JD. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J Neurosci. 2002 Aug 1;22(15):6372-9
• Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI, Rothman DL. Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci. 2002 Mar 1;22(5):1523-31.
• d'Errico, F., Nath., R., Holland, S.K., Lamba, M., Patz, S. and Rivard, M.J. A Position Sensitive Neutron Spectrometer/Dosimeter Based on Pressurized Superheated Drop (Bubble) Detectors. Nucl. Instr. Methods A476(1-2) 113-118 (2002).
• Apfel, R.E., and d'Errico, F. A Neutron Spectrometer Based on Temperature Variations in Superheated Drop Compositions. Nucl. Instr. Methods A476 (1-2) 298-303 (2002).
• Pratt, R., Schmithorst, V., Lamba, M., Dardzinski, B., Holland, S.K., d'Errico, F., and Nath R. System for Automated Magnetic Resonance Imaging of a Superheated Emulsion Chamber for Brachytherapy Dosimetry. Rev. Sci. Instruments 73(6) 2417-2421 (2002).
• Eke, A., Herman, P., Kocsis L., Kozak L.R. (2002) Fractal characterization of complexity in temporal physiological signals. Physiol. Meas. 23:R1-R38.
• Daniel Coman and Irina M. Russu. Site-resolved energetics in DNA triple helices containing G.TA and T.CG triads. Biochemistry, 2002, 41(13): 4407-4414.

2001

• O. Fokapu, H. Chahboune, M. Armenean, P. Desgoutte, R. Cespuglio, A. Briguet. Denoising EMG and EEG for monitoring small animal models during NMR experiments, IEEE, 2, 1824-1827, 2001.
• d'Errico, F. Radiation Dosimetry and Spectrometry with Superheated Emulsions. Nucl. Instr. Methods B 184(1-2) 229-254 (2001).
• Herman, P., L. Kocsis, A. Eke (2001) Fractal branching pattern in the pial vasculature in the cat. J. Cereb. Blood Flow and Metabol., 21:741-754.
• Mason GF, Martin DL, Martin SB, Manor D, Sibson NR, Patel A, Rothman DL, Behar KL (2001) Decrease in GABA synthesis rate in rat cortex following vigabatrin administration correlates with the decrease in GAD67 protein. Brain Research 914: 81-91.

2000

• d'Errico, F., Nath, R. and Nolte, R. A Model for Photon Detection and Dosimetry with Superheated Emulsions. Med. Phys. 27 (2) 401-409 (2000).
• Eke, A., P. Herman, J.B. Bassingthwaighte, G.M. Raymond, D.B. Percival, M. Cannon, I. Balla, and C. Ikrenyi. (2000) Physiological time series: distinguishing fractal noises from motions. Pflugers Arch. - Eur. J. Physiol., 439: 403-415.