MRS Group Publications

Juchem C, Umesh Rudrapatna S, Nixon TW and de Graaf RA: Dynamic multi-coil technique (DYNAMITE) shimming for echo-planar imaging of the human brain at 7 Tesla. Neuroimage. 2015 Jan 15;105 :462-72. Epub 2014 Nov 8. PMID: 25462795

Maritim S, Huang Y, Coman D and Hyder F: Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). J Biol Inorg Chem. 2014 Dec;19 (8) :1385-98. Epub 2014 Oct 11. PMID: 25304046


Cheng DW, Ersahin D, Staib LH, Della Latta D, Giorgetti A and d'Errico F: Using SUV as a Guide to 18F-FDG Dose Reduction. J Nucl Med. 2014 Dec;55 (12) :1998-2002. Epub 2014 Nov 13. PMID: 25453048


Romei C, Di Fulvio A, Traino CA, Ciolini R and d'Errico F: Characterization of a low-cost PIN photodiode for dosimetry in diagnostic radiology. Phys Med. 2014 Nov 20; Epub 2014 Nov 20. PMID: 25465072


Strohbehn G, Coman D, Han L, Ragheb RR, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM and Zhou J: Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. J Neurooncol. 2014 Nov 18; Epub 2014 Nov 18. PMID: 25403507


Shulman RG, Hyder F and Rothman DL: Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior. J Cereb Blood Flow Metab. 2014 Nov;34 (11) :1721-1735. Epub 2014 Aug 27. PMID: 25160670


Bagga P, Behar KL, Mason GF, De Feyter HM, Rothman DL and Patel AB: Characterization of cerebral glutamine uptake from blood in the mouse brain: implications for metabolic modeling of 13C NMR data. J Cereb Blood Flow Metab. 2014 Oct;34 (10) :1666-72. Epub 2014 Jul 30. PMID: 25074745


de Graaf RA, De Feyter HM and Rothman DL: High-sensitivity, broadband-decoupled <sup>13</sup> C MR spectroscopy in humans at 7T using two-dimensional heteronuclear single-quantum coherence. Magn Reson Med. 2014 Sep 29; Epub 2014 Sep 29. PMID: 25264872


Lin AL, Coman D, Jiang L, Rothman DL and Hyder F: Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. J Cereb Blood Flow Metab. 2014 Sep;34 (9) :1440-3. Epub 2014 Jul 2. PMID: 24984898


Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F and Strittmatter SM: Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery. J Neurotrauma. 2014 Aug 1;31 (15) :1362-73. Epub 2014 Jul 8. PMID: 24779685


Juchem C, Herman P, Sanganahalli BG, Brown PB, McIntyre S, Nixon TW, Green D, Hyder F and de Graaf RA: DYNAmic Multi-coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7 T. NMR Biomed. 2014 Aug;27 (8) :897-906. Epub 2014 May 17. PMID: 24839167


Chowdhury GM, Jiang L, Rothman DL and Behar KL: The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo. J Cereb Blood Flow Metab. 2014 Jul;34 (7) :1233-42. Epub 2014 Apr 30. PMID: 24780902


Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL and Shulman GI: Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat Med. 2014 Jul;20 (7) :759-63. Epub 2014 Jun 15. PMID: 24929951


de Graaf RA and Behar KL: Detection of cerebral NAD(+) by in vivo (1)H NMR spectroscopy. NMR Biomed. 2014 Jul;27 (7) :802-9. Epub 2014 May 15. PMID: 24831866


de Graaf RA, Chowdhury GM and Behar KL: Quantification of high-resolution ¹H-[¹³C] NMR spectra from rat brain extracts. Anal Chem. 2014 May 20;86 (10) :5032-8. Epub 2014 May 9. PMID: 24773047


Huang Y, Coman D, Ali MM and Hyder F: Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS). Contrast Media Mol Imaging. 2014 May 6; Epub 2014 May 6. PMID: 24801742


Lin AL and Rothman DL: What have novel imaging techniques revealed about metabolism in the aging brain? Future Neurol. 2014 May 1;9 (3) :341-354. PMID: 25214817


Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL and Hyder F: Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by (19)F chemical shift imaging. Magn Reson Imaging. 2014 May;32 (4) :305-13. Epub 2013 Dec 14. PMID: 24581725


Patel AB, Lai JC, Chowdhury GM, Hyder F, Rothman DL, Shulman RG and Behar KL: Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc Natl Acad Sci U S A. 2014 Apr 8;111 (14) :5385-90. Epub 2014 Mar 26. PMID: 24706914


Pugh KR, Frost SJ, Rothman DL, Hoeft F, Del Tufo SN, Mason GF, Molfese PJ, Mencl WE, Grigorenko EL, Landi N, Preston JL, Jacobsen L, Seidenberg MS and Fulbright RK: Glutamate and choline levels predict individual differences in reading ability in emergent readers. J Neurosci. 2014 Mar 12;34 (11) :4082-9. PMID: 24623786


Niciu MJ and Mason GF: Neuroimaging in Alcohol and Drug Dependence. Curr Behav Neurosci Rep. 2014 Mar 1;1 (1) :45-54. PMID: 24678450


Scafidi J, Hammond TR, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter RJ Jr, Hyder F, Horvath TL and Gallo V: Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature. 2014 Feb 13;506 (7487) :230-4. Epub 2013 Dec 25. PMID: 24390343


Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF and Shulman GI: Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nat Med. 2014 Jan;20 (1) :98-102. Epub 2013 Dec 8. PMID: 24317120


Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT and Ment LR: GABA, resting-state connectivity and the developing brain. Neonatology. 2014;106 (2) :149-55. Epub 2014 Jun 26. PMID: 24970028


Mishra AM, Bai X, Sanganahalli BG, Waxman SG, Shatillo O, Grohn O, Hyder F, Pitkänen A and Blumenfeld H: Decreased resting functional connectivity after traumatic brain injury in the rat. PLoS One. 2014;9 (4) :e95280. Epub 2014 Apr 18. PMID: 24748279


Abdallah CG, Niciu MJ, Fenton LR, Fasula MK, Jiang L, Black A, Rothman DL, Mason GF and Sanacora G: Decreased occipital cortical glutamate levels in response to successful cognitive-behavioral therapy and pharmacotherapy for major depressive disorder. Psychother Psychosom. 2014;83 (5) :298-307. Epub 2014 Aug 6. PMID: 25116726

Solecki W, Wickham RJ, Behrens S, Wang J, Zwerling B, Mason GF and Addy NA: Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking. Neuropharmacology. 2013 Dec;75 :9-18. Epub 2013 Jul 11. PMID: 23850572


Juchem C, Green D and de Graaf RA: Multi-coil magnetic field modeling. J Magn Reson. 2013 Nov;236 :95-104. Epub 2013 Sep 13. PMID: 24095841


Wang J, Du H, Ma X, Pittman B, Castracane L, Li TK, Behar KL and Mason GF: Metabolic products of [2-(13) C]ethanol in the rat brain after chronic ethanol exposure. J Neurochem. 2013 Nov;127 (3) :353-64. Epub 2013 Sep 23. PMID: 24033360


Coman D, de Graaf RA, Rothman DL and Hyder F: In vivo three-dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR Biomed. 2013 Nov;26 (11) :1589-95. Epub 2013 Jul 24. PMID: 23881869


Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL and Hyder F: Functional MRI and neural responses in a rat model of Alzheimer's disease. Neuroimage. 2013 Oct 1;79 :404-11. Epub 2013 May 3. PMID: 23648961


Herman P, Sanganahalli BG, Blumenfeld H, Rothman DL and Hyder F: Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI. Proc Natl Acad Sci U S A. 2013 Sep 10;110 (37) :15115-20. Epub 2013 Aug 26. PMID: 23980158


De Feyter HM, Mason GF, Shulman GI, Rothman DL and Petersen KF: Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals. Diabetes. 2013 Sep;62 (9) :3075-80. Epub 2013 May 28. PMID: 23715622


Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL and Sherwin RS: Increased brain transport and metabolism of acetate in hypoglycemia unawareness. J Clin Endocrinol Metab. 2013 Sep;98 (9) :3811-20. Epub 2013 Jun 24. PMID: 23796565


Mishra AM, Bai X, Motelow JE, Desalvo MN, Danielson N, Sanganahalli BG, Hyder F and Blumenfeld H: Increased resting functional connectivity in spike-wave epilepsy in WAG/Rij rats. Epilepsia. 2013 Jul;54 (7) :1214-22. PMID: 23815571


Sanganahalli BG, Herman P, Hyder F and Kannurpatti SS: Mitochondrial calcium uptake capacity modulates neocortical excitability. J Cereb Blood Flow Metab. 2013 Jul;33 (7) :1115-26. Epub 2013 Apr 17. PMID: 23591650


Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS and Behar KL: Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. J Clin Invest. 2013 May 1;123 (5) :1988-98. Epub 2013 Apr 1. PMID: 23543056


Sanganahalli BG, Herman P, Hyder F and Kannurpatti SS: Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI. PLoS One. 2013;8 (5) :e63317. Epub 2013 May 1. PMID: 23650561


Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH and Mason GF: Increased brain uptake and oxidation of acetate in heavy drinkers. J Clin Invest. 2013 Apr 1;123 (4) :1605-14. Epub 2013 Mar 8. PMID: 23478412


de Graaf RA, Klomp DW, Luijten PR and Boer VO: Intramolecular zero-quantum-coherence 2D NMR spectroscopy of lipids in the human breast at 7 T. Magn Reson Med. 2013 Mar 6; Epub 2013 Mar 6. PMID: 23468435


Hyder F, Fulbright RK, Shulman RG and Rothman DL: Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy. J Cereb Blood Flow Metab. 2013 Mar;33 (3) :339-47. Epub 2013 Jan 9. PMID: 23299240


Hyder F, Rothman DL and Bennett MR: Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels. Proc Natl Acad Sci U S A. 2013 Feb 26;110 (9) :3549-54. Epub 2013 Jan 14. PMID: 23319606


Stockmann JP, Galiana G, Tam L, Juchem C, Nixon TW and Constable RT: In vivo O-Space imaging with a dedicated 12 cm Z2 insert coil on a human 3T scanner using phase map calibration. Magn Reson Med. 2013 Feb;69 (2) :444-55. Epub 2012 May 14. PMID: 22585546


Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A and Hyder F: Analysis of time and space invariance of BOLD responses in the rat visual system. Cereb Cortex. 2013 Jan;23 (1) :210-22. Epub 2012 Jan 31. PMID: 22298731

Lacar B, Herman P, Platel JC, Kubera C, Hyder F and Bordey A: Neural progenitor cells regulate capillary blood flow in the postnatal subventricular zone. J Neurosci. 2012 Nov 14;32 (46) :16435-48. PMID: 23152626


Carlyle BC, Duque A, Kitchen RR, Bordner KA, Coman D, Doolittle E, Papademetris X, Hyder F, Taylor JR and Simen AA: Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits. Dev Psychopathol. 2012 Nov;24 (4) :1401-16. PMID: 23062306


Befroy DE, Rothman DL, Petersen KF and Shulman GI: ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism. Diabetes. 2012 Nov;61 (11) :2669-78. PMID: 23093656


Rothman DL, De Feyter HM, Maciejewski PK and Behar KL: Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes? Neurochem Res. 2012 Nov;37 (11) :2597-612. Epub 2012 Oct 27. PMID: 23104556


Eid T, Behar K, Dhaher R, Bumanglag AV and Lee TS: Roles of glutamine synthetase inhibition in epilepsy. Neurochem Res. 2012 Nov;37 (11) :2339-50. Epub 2012 Apr 10. PMID: 22488332


Hyder F and Rothman DL: Quantitative fMRI and oxidative neuroenergetics. Neuroimage. 2012 Aug 15;62 (2) :985-94. Epub 2012 Apr 19. PMID: 22542993


Chowdhury GM, Behar KL, Cho W, Thomas MA, Rothman DL and Sanacora G: ¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism. Biol Psychiatry. 2012 Jun 1;71 (11) :1022-5. Epub 2011 Dec 9. PMID: 22169441


Morgan PT, Pace-Schott EF, Mason GF, Forselius E, Fasula M, Valentine GW and Sanacora G: Cortical GABA levels in primary insomnia. Sleep. 2012 Jun 1;35 (6) :807-14. Epub 2012 Jun 1. PMID: 22654200


Duque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F and Simen AA: Neuroanatomical changes in a mouse model of early life neglect. Brain Struct Funct. 2012 Apr;217 (2) :459-72. Epub 2011 Oct 8. PMID: 21984312


Eke A, Herman P, Sanganahalli BG, Hyder F, Mukli P and Nagy Z: Pitfalls in Fractal Time Series Analysis: fMRI BOLD as an Exemplary Case. Front Physiol. 2012;3 :417. Epub 2012 Nov 15. PMID: 23227008


Lacar B, Herman P, Hartman NW, Hyder F and Bordey A: S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. PLoS One. 2012;7 (2) :e31960. Epub 2012 Feb 16. PMID: 22359646

Jiang L, Mason GF, Rothman DL, de Graaf RA and Behar KL: Cortical substrate oxidation during hyperketonemia in the fasted anesthetized rat in vivo. J Cereb Blood Flow Metab. 2011 Dec;31 (12) :2313-23. Epub 2011 Jul 6. PMID: 21731032


Coman D, Kiefer GE, Rothman DL, Sherry AD and Hyder F: A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate. NMR Biomed. 2011 Dec;24 (10) :1216-25. PMID: 22020775


Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F and Blumenfeld H: Where fMRI and electrophysiology agree to disagree: corticothalamic and striatal activity patterns in the WAG/Rij rat. J Neurosci. 2011 Oct 19;31 (42) :15053-64. PMID: 22016539


Herman P, Sanganahalli BG, Hyder F and Eke A: Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain. Neuroimage. 2011 Oct 15;58 (4) :1060-9. Epub 2011 Jul 12. PMID: 21777682


Juchem C, Nixon TW, McIntyre S, Boer VO, Rothman DL and de Graaf RA: Dynamic multi-coil shimming of the human brain at 7 T. J Magn Reson. 2011 Oct;212 (2) :280-8. Epub 2011 Jul 23. PMID: 21824794


de Graaf RA, Rothman DL and Behar KL: State of the art direct 13C and indirect 1H-[13C] NMR spectroscopy in vivo. A practical guide. NMR Biomed. 2011 Oct;24 (8) :958-72. Epub 2011 Aug 23. PMID: 21919099


Rothman DL, De Feyter HM, de Graaf RA, Mason GF and Behar KL: 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR Biomed. 2011 Oct;24 (8) :943-57. Epub 2011 Aug 31. PMID: 21882281


Juchem C, Brown PB, Nixon TW, McIntyre S, Rothman DL and de Graaf RA: Multicoil shimming of the mouse brain. Magn Reson Med. 2011 Sep;66 (3) :893-900. Epub 2011 Mar 25. PMID: 21442653


Herzog RI, Sherwin RS and Rothman DL: Insulin-induced hypoglycemia and its effect on the brain: unraveling metabolism by in vivo nuclear magnetic resonance. Diabetes. 2011 Jul;60 (7) :1856-8. PMID: 21709281


Cosgrove KP, Esterlis I, Mason GF, Bois F, O'Malley SS and Krystal JH: Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. Neuropharmacology. 2011 Jun;60 (7-8) :1318-25. Epub 2011 Jan 27. PMID: 21276806


Befroy DE and Shulman GI: Magnetic resonance spectroscopy studies of human metabolism. Diabetes. 2011 May;60 (5) :1361-9. PMID: 21525507


Hyder F and Rothman DL: Evidence for the importance of measuring total brain activity in neuroimaging. Proc Natl Acad Sci U S A. 2011 Apr 5;108 (14) :5475-6. Epub 2011 Mar 24. PMID: 21441108


Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Falk Petersen K and Shulman GI: Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance. Hepatology. 2011 Apr;53 (4) :1175-81. Epub 2011 Mar 11. PMID: 21400553


Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH and Sanacora G: The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS. Psychiatry Res. 2011 Feb 28;191 (2) :122-7. Epub 2011 Jan 12. PMID: 21232924


de Graaf RA, Chowdhury GM and Behar KL: Quantification of high-resolution (1)H NMR spectra from rat brain extracts. Anal Chem. 2011 Jan 1;83 (1) :216-24. Epub 2010 Dec 13. PMID: 21142125


Palejev D, Hwang W, Landi N, Eastman M, Frost SJ, Fulbright RK, Kidd JR, Kidd KK, Mason GF, Mencl WE, Yrigollen C, Pugh KR and Grigorenko EL: An application of the elastic net for an endophenotype analysis. Behav Genet. 2011 Jan;41 (1) :120-4. Epub 2011 Jan 13. PMID: 21229297


Hyder F, Herman P, Sanganahalli BG, Coman D, Blumenfeld H and Rothman DL: Role of ongoing, intrinsic activity of neuronal populations for quantitative neuroimaging of functional magnetic resonance imaging-based networks. Brain Connect. 2011;1 (3) :185-93. PMID: 22433047


Shulman RG: A philosophical analysis of neuroenergetics. Front Neuroenergetics. 2011;3 :6. Epub 2011 Nov 18. PMID: 22121346

Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI and Rothman DL: The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci. 2010 Oct 20;30 (42) :13983-91. PMID: 20962220


Juchem C, Nixon TW, Diduch P, Rothman DL, Starewicz P and de Graaf RA: Dynamic Shimming of the Human Brain at 7 Tesla. Concepts Magn Reson Part B Magn Reson Eng. 2010 Jul 6;37B (3) :116-128. PMID: 20657809


Leuenroth SJ, Bencivenga N, Chahboune H, Hyder F and Crews CM: Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD. Nephrol Dial Transplant. 2010 Jul;25 (7) :2187-94. Epub 2010 Feb 4. PMID: 20139063


Hyder F and Rothman DL: Neuronal correlate of BOLD signal fluctuations at rest: err on the side of the baseline. Proc Natl Acad Sci U S A. 2010 Jun 15;107 (24) :10773-4. Epub 2010 Jun 8. PMID: 20534504


Patel AB, de Graaf RA, Rothman DL, Behar KL and Mason GF: Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR. J Cereb Blood Flow Metab. 2010 Jun;30 (6) :1200-13. Epub 2010 Feb 3. PMID: 20125180


Juchem C, Nixon TW, McIntyre S, Rothman DL and de Graaf RA: Magnetic field modeling with a set of individual localized coils. J Magn Reson. 2010 Jun;204 (2) :281-9. Epub 2010 Mar 11. PMID: 20347360


Wang J, Jiang L, Jiang Y, Ma X, Chowdhury GM and Mason GF: Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine. J Neurochem. 2010 Jun;113 (6) :1447-58. Epub 2010 Mar 14. PMID: 20345764


Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL and Sanacora G: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry. 2010 May;15 (5) :501-11. Epub 2008 Sep 30. PMID: 18825147


DeSalvo MN, Schridde U, Mishra AM, Motelow JE, Purcaro MJ, Danielson N, Bai X, Hyder F and Blumenfeld H: Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat. Neuroimage. 2010 Apr 15;50 (3) :902-9. Epub 2010 Jan 14. PMID: 20079442


Coman D, Trubel HK and Hyder F: Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5- and TmDOTMA-. NMR Biomed. 2010 Apr;23 (3) :277-85. PMID: 19957287


Fitzgerald TN, Muto A, Fancher TT, Brown PB, Martin KA, Muhs BE, Rothman DL, Constable RT, Sampath S and Dardik A: Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamics. Ann Vasc Surg. 2010 Feb;24 (2) :242-53. Epub 2009 Dec 29. PMID: 20036497


Hyder F, Sanganahalli BG, Herman P, Coman D, Maandag NJ, Behar KL, Blumenfeld H and Rothman DL: Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms. Front Neuroenergetics. 2010;2 Epub 2010 Aug 19. PMID: 20838476


Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL and Petersen KF: Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 2010 Jan;30 (1) :211-21. Epub 2009 Sep 30. PMID: 19794401


Juchem C, Nixon TW, McIntyre S, Rothman DL and de Graaf RA: Magnetic field homogenization of the human prefrontal cortex with a set of localized electrical coils. Magn Reson Med. 2010 Jan;63 (1) :171-80. PMID: 19918909

Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F and Schwartz ML: Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment. Cereb Cortex. 2009 Dec;19 (12) :2891-901. Epub 2009 Apr 20. PMID: 19380380


Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F and Blumenfeld H: Cortical deactivation induced by subcortical network dysfunction in limbic seizures. J Neurosci. 2009 Oct 14;29 (41) :13006-18. PMID: 19828814


Shulman RG, Hyder F and Rothman DL: Baseline brain energy supports the state of consciousness. Proc Natl Acad Sci U S A. 2009 Jul 7;106 (27) :11096-101. Epub 2009 Jun 19. PMID: 19549837


Jiang L, Herzog RI, Mason GF, de Graaf RA, Rothman DL, Sherwin RS and Behar KL: Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo. Diabetes. 2009 Jun;58 (6) :1266-74. Epub 2009 Mar 10. PMID: 19276443


Herman P, Sanganahalli BG, Blumenfeld H and Hyder F: Cerebral oxygen demand for short-lived and steady-state events. J Neurochem. 2009 May;109 Suppl 1 :73-9. PMID: 19393011


de Graaf RA, Chowdhury GM, Brown PB, Rothman DL and Behar KL: In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research. J Neurochem. 2009 Apr;109 (2) :494-501. Epub 2009 Feb 7. PMID: 19200336


Musa-Aziz R, Jiang L, Chen LM, Behar KL and Boron WF: Concentration-dependent effects on intracellular and surface pH of exposing Xenopus oocytes to solutions containing NH3/NH4(+). J Membr Biol. 2009 Mar;228 (1) :15-31. Epub 2009 Feb 26. PMID: 19242745


Sanganahalli BG, Herman P, Blumenfeld H and Hyder F: Oxidative neuroenergetics in event-related paradigms. J Neurosci. 2009 Feb 11;29 (6) :1707-18. PMID: 19211878


Coman D, Trubel HK, Rycyna RE and Hyder F: Brain temperature and pH measured by (1)H chemical shift imaging of a thulium agent. NMR Biomed. 2009 Feb;22 (2) :229-39. PMID: 19130468


Herman P, Sanganahalli BG and Hyder F: Multimodal measurements of blood plasma and red blood cell volumes during functional brain activation. J Cereb Blood Flow Metab. 2009 Jan;29 (1) :19-24. Epub 2008 Sep 3. PMID: 18766196


Befroy DE, Falk Petersen K, Rothman DL and Shulman GI: Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods Enzymol. 2009;457 :373-93. PMID: 19426879


Sanganahalli BG, Bailey CJ, Herman P and Hyder F: Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents. Methods Mol Biol. 2009;489 :213-42. PMID: 18839094


Herman P, Kocsis L and Eke A: Fractal characterization of complexity in dynamic signals: application to cerebral hemodynamics. Methods Mol Biol. 2009;489 :23-40. PMID: 18839086


Hyder F: Dynamic imaging of brain function. Methods Mol Biol. 2009;489 :3-21. PMID: 18839085

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM and Shulman GI: Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A. 2008 Dec 16;105 (50) :19926-31. Epub 2008 Dec 9. PMID: 19066218


Chowdhury GM, Banasr M, de Graaf RA, Rothman DL, Behar KL and Sanacora G: Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus. J Cereb Blood Flow Metab. 2008 Dec;28 (12) :1892-7. Epub 2008 Jul 16. PMID: 18628780


De Feyter HM, Lenaers E, Houten SM, Schrauwen P, Hesselink MK, Wanders RJ, Nicolay K and Prompers JJ: Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. FASEB J. 2008 Nov;22 (11) :3947-55. Epub 2008 Jul 24. PMID: 18653763


Befroy DE, Petersen KF, Dufour S, Mason GF, Rothman DL and Shulman GI: Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals. Proc Natl Acad Sci U S A. 2008 Oct 28;105 (43) :16701-6. Epub 2008 Oct 20. PMID: 18936488


Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F and Blumenfeld H: Remote effects of focal hippocampal seizures on the rat neocortex. J Neurosci. 2008 Sep 3;28 (36) :9066-81. PMID: 18768701


Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F and Blumenfeld H: Negative BOLD with large increases in neuronal activity. Cereb Cortex. 2008 Aug;18 (8) :1814-27. Epub 2007 Dec 5. PMID: 18063563


Lesnik GT, Remenschneider AK, Herman P, Ross A and Ross DA: Capillary blood gas: a novel means of assessing free flap perfusion in an animal model. Otolaryngol Head Neck Surg. 2008 Aug;139 (2) :250-5. PMID: 18656724


de Graaf RA, Brown PB, Rothman DL and Behar KL: Natural abundance (17)O NMR spectroscopy of rat brain in vivo. J Magn Reson. 2008 Jul;193 (1) :63-7. Epub 2008 May 5. PMID: 18456525


Nixon TW, McIntyre S, Rothman DL and de Graaf RA: Compensation of gradient-induced magnetic field perturbations. J Magn Reson. 2008 Jun;192 (2) :209-17. Epub 2008 Feb 23. PMID: 18329304


Sanganahalli BG, Herman P and Hyder F: Frequency-dependent tactile responses in rat brain measured by functional MRI. NMR Biomed. 2008 May;21 (4) :410-6. PMID: 18435491


Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA Jr, Cook EH Jr, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA and McCandless R: It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15;63 (8) :725-7. PMID: 18371494


Kim H, Taksali SE, Dufour S, Befroy D, Goodman TR, Petersen KF, Shulman GI, Caprio S and Constable RT: Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magn Reson Med. 2008 Mar;59 (3) :521-7. PMID: 18306404


Maciejewski PK and Rothman DL: Proposed cycles for functional glutamate trafficking in synaptic neurotransmission. Neurochem Int. 2008 Mar-Apr;52 (4-5) :809-25. Epub 2007 Oct 2. PMID: 18006192

Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG and Hyder F: Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci U S A. 2007 Dec 18;104 (51) :20546-51. Epub 2007 Dec 13. PMID: 18079290


Chowdhury GM, Patel AB, Mason GF, Rothman DL and Behar KL: Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development. J Cereb Blood Flow Metab. 2007 Dec;27 (12) :1895-907. Epub 2007 Apr 18. PMID: 17440492


Chowdhury GM, Gupta M, Gibson KM, Patel AB and Behar KL: Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling. J Neurochem. 2007 Dec;103 (5) :2077-91. Epub 2007 Sep 13. PMID: 17854388


Qin Q, Gore JC, de Graaf RA and Does MD: Quantitative T2 measurement of a single voxel with arbitrary shape using pinwheel excitation and CPMG acquisition. MAGMA. 2007 Dec;20 (5-6) :233-40. Epub 2007 Nov 13. PMID: 17999101


de Graaf RA, Rothman DL and Behar KL: High resolution NMR spectroscopy of rat brain in vivo through indirect zero-quantum-coherence detection. J Magn Reson. 2007 Aug;187 (2) :320-6. Epub 2007 Jun 10. PMID: 17587617


Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL and Shulman GI: The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 2007 Jul 31;104 (31) :12587-94. Epub 2007 Jul 18. PMID: 17640906


Qin Q, Gore JC, Does MD, Avison MJ and de Graaf RA: 2D arbitrary shape-selective excitation summed spectroscopy (ASSESS). Magn Reson Med. 2007 Jul;58 (1) :19-26. PMID: 17659614


Shulman RG, Rothman DL and Hyder F: A BOLD search for baseline. Neuroimage. 2007 Jun;36 (2) :277-81. Epub 2007 Jan 16. PMID: 17223362


Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL and Shulman GI: Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes. 2007 May;56 (5) :1376-81. Epub 2007 Feb 7. PMID: 17287462


Chahboune H, Ment LR, Stewart WB, Ma X, Rothman DL and Hyder F: Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging. NMR Biomed. 2007 May;20 (3) :375-82. PMID: 17451176


Kida I, Rothman DL and Hyder F: Dynamics of changes in blood flow, volume, and oxygenation: implications for dynamic functional magnetic resonance imaging calibration. J Cereb Blood Flow Metab. 2007 Apr;27 (4) :690-6. Epub 2006 Oct 11. PMID: 17033688


Koch KM, Sacolick LI, Nixon TW, McIntyre S, Rothman DL and de Graaf RA: Dynamically shimmed multivoxel 1H magnetic resonance spectroscopy and multislice magnetic resonance spectroscopic imaging of the human brain. Magn Reson Med. 2007 Mar;57 (3) :587-91. PMID: 17326186


Sacolick LI, Rothman DL and de Graaf RA: Adiabatic refocusing pulses for volume selection in magnetic resonance spectroscopic imaging. Magn Reson Med. 2007 Mar;57 (3) :548-53. PMID: 17326179


Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH and Shulman GI: Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab. 2007 Feb;5 (2) :151-6. PMID: 17276357


Mason GF: Get sober; stay sober. Brain. 2007 Jan;130 (Pt 1) :8-9. PMID: 17178741


Mason GF, Petersen KF, de Graaf RA, Shulman GI and Rothman DL: Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose. J Neurochem. 2007 Jan;100 (1) :73-86. Epub 2006 Oct 31. PMID: 17076763

Koch KM, Papademetris X, Rothman DL and de Graaf RA: Rapid calculations of susceptibility-induced magnetostatic field perturbations for in vivo magnetic resonance. Phys Med Biol. 2006 Dec 21;51 (24) :6381-402. Epub 2006 Nov 27. PMID: 17148824


Carpenter TO, DeLucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J, Petersen KF, Befroy D and Cohen D: A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. J Clin Endocrinol Metab. 2006 Dec;91 (12) :4866-72. Epub 2006 Oct 3. PMID: 17018656


Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Dalla Man C, Cobelli C and Shulman GI: Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A. 2006 Nov 28;103 (48) :18273-7. Epub 2006 Nov 17. PMID: 17114290


Vartanian LR, Herman CP and Polivy J: Does regulatory focus play a role in dietary restraint? Eat Behav. 2006 Nov;7 (4) :333-41. Epub 2005 Nov 21. PMID: 17056409


Mason GF and Krystal JH: MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases. NMR Biomed. 2006 Oct;19 (6) :690-701. PMID: 16986118


Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J and Lappalainen J: Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Arch Gen Psychiatry. 2006 Sep;63 (9) :957-68. PMID: 16952998


Koch KM, Brown PB, Rothman DL and de Graaf RA: Sample-specific diamagnetic and paramagnetic passive shimming. J Magn Reson. 2006 Sep;182 (1) :66-74. Epub 2006 Jun 30. PMID: 16814580


de Graaf RA, Brown PB, McIntyre S, Nixon TW, Behar KL and Rothman DL: High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo. Magn Reson Med. 2006 Aug;56 (2) :386-94. PMID: 16767752


Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL and Epperson CN: The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacol Biochem Behav. 2006 Aug;84 (4) :635-43. Epub 2006 Jul 24. PMID: 16860856


Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL and Shulman RG: Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. J Cereb Blood Flow Metab. 2006 Jul;26 (7) :865-77. Epub 2006 Jan 11. PMID: 16407855


Song H, Roa DE, Yue N, d'Errico F, Chen Z and Nath R: Application of Gafchromic film in the dosimetry of an intravascular brachytherapy source. Med Phys. 2006 Jul;33 (7) :2519-24. PMID: 16898455


Schafer JR, Kida I, Xu F, Rothman DL and Hyder F: Reproducibility of odor maps by fMRI in rodents. Neuroimage. 2006 Jul 1;31 (3) :1238-46. Epub 2006 Apr 24. PMID: 16632382


Koch KM, McIntyre S, Nixon TW, Rothman DL and de Graaf RA: Dynamic shim updating on the human brain. J Magn Reson. 2006 Jun;180 (2) :286-96. Epub 2006 Mar 30. PMID: 16574443


Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL and Mason GF: Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology (Berl). 2006 Jun;186 (3) :425-33. Epub 2006 May 3. PMID: 16724188


Vartanian LR and Herman CP: Beliefs about the determinants of body weight predict dieting and exercise behavior. Eat Behav. 2006 May;7 (2) :176-9. Epub 2005 Aug 30. PMID: 16600845


de Graaf RA, Patel AB, Rothman DL and Behar KL: Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex. Neurochem Int. 2006 May-Jun;48 (6-7) :508-14. Epub 2006 Mar 3. PMID: 16517019


Mason GF, Petersen KF, Lebon V, Rothman DL and Shulman GI: Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes. 2006 Apr;55 (4) :929-34. PMID: 16567513


Patel AB, de Graaf RA, Martin DL, Battaglioli G and Behar KL: Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo. J Neurochem. 2006 Apr;97 (2) :385-96. Epub 2006 Mar 15. PMID: 16539672


Petroff OA, Hyder F, Rothman DL and Mattson RH: Brain homocarnosine and seizure control of patients taking gabapentin or topiramate. Epilepsia. 2006 Mar;47 (3) :495-8. PMID: 16529611


Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH and Mason GF: Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biol Psychiatry. 2006 Feb 1;59 (3) :284-6. Epub 2005 Sep 1. PMID: 16139814


Mason GF, Petrakis IL, de Graaf RA, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL and Krystal JH: Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking. Biol Psychiatry. 2006 Jan 1;59 (1) :85-93. Epub 2005 Nov 14. PMID: 16289397


Hermán P, Trübel HK and Hyder F: A multiparametric assessment of oxygen efflux from the brain. J Cereb Blood Flow Metab. 2006 Jan;26 (1) :79-91. PMID: 15973353


Trübel HK, Sacolick LI and Hyder F: Regional temperature changes in the brain during somatosensory stimulation. J Cereb Blood Flow Metab. 2006 Jan;26 (1) :68-78. PMID: 15959461


Kida I, Smith AJ, Blumenfeld H, Behar KL and Hyder F: Lamotrigine suppresses neurophysiological responses to somatosensory stimulation in the rodent. Neuroimage. 2006 Jan 1;29 (1) :216-24. Epub 2005 Aug 19. PMID: 16112588


d'Errico F: Status of radiation detection with superheated emulsions. Radiat Prot Dosimetry. 2006;120 (1-4) :475-9. Epub 2006 Jul 25. PMID: 16868012

Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M and Shulman GI: Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest. 2005 Dec;115 (12) :3587-93. Epub 2005 Nov 10. PMID: 16284649


Shulman RG: Glycogen turnover forms lactate during exercise. Exerc Sport Sci Rev. 2005 Oct;33 (4) :157-62. PMID: 16239831


Xu F, Schaefer M, Kida I, Schafer J, Liu N, Rothman DL, Hyder F, Restrepo D and Shepherd GM: Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones. J Comp Neurol. 2005 Sep 5;489 (4) :491-500. PMID: 16025460


Schafer JR, Kida I, Rothman DL, Hyder F and Xu F: Adaptation in the rodent olfactory bulb measured by fMRI. Magn Reson Med. 2005 Aug;54 (2) :443-8. PMID: 16032685


Safriel Y, Pol-Rodriguez M, Novotny EJ, Rothman DL and Fulbright RK: Reference values for long echo time MR spectroscopy in healthy adults. AJNR Am J Neuroradiol. 2005 Jun-Jul;26 (6) :1439-45. PMID: 15956513


de Graaf RA: Theoretical and experimental evaluation of broadband decoupling techniques for in vivo nuclear magnetic resonance spectroscopy. Magn Reson Med. 2005 Jun;53 (6) :1297-306. PMID: 15906279


Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG and Behar KL: The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. Proc Natl Acad Sci U S A. 2005 Apr 12;102 (15) :5588-93. Epub 2005 Apr 4. PMID: 15809416


Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE and Shulman GI: Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes. 2005 Mar;54 (3) :603-8. PMID: 15734833


Epperson CN, O'Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH and Mason GF: Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biol Psychiatry. 2005 Jan 1;57 (1) :44-8. PMID: 15607299


Qin Q, de Graaf R, Does M and Gore J: Calculation of RF Peak Power for 2D Arbitrary Shape Excitation in MRI. Conf Proc IEEE Eng Med Biol Soc. 2005;2 :1340-3. PMID: 17282444


Papademetris X, Shkarin P, Staib LH and Behar KL: Regional whole body fat quantification in mice. Inf Process Med Imaging. 2005;19 :369-80. PMID: 17354710


Patel AB, Chowdhury GM, de Graaf RA, Rothman DL, Shulman RG and Behar KL: Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures. J Neurosci Res. 2005 Jan 1-15;79 (1-2) :128-38. PMID: 15562501

Kida I, Maciejewski PK and Hyder F: Dynamic imaging of perfusion and oxygenation by functional magnetic resonance imaging. J Cereb Blood Flow Metab. 2004 Dec;24 (12) :1369-81. PMID: 15625411


Hyder F: Neuroimaging with calibrated FMRI. Stroke. 2004 Nov;35 (11 Suppl 1) :2635-41. Epub 2004 Sep 23. PMID: 15388903


Trübel H, Herman P, Kampmann C, Huth R, Maciejewski PK, Novotny E and Hyder F: A novel approach for selective brain cooling: implications for hypercapnia and seizure activity. Intensive Care Med. 2004 Sep;30 (9) :1829-33. Epub 2004 Jun 8. PMID: 15185071


Nersesyan H, Herman P, Erdogan E, Hyder F and Blumenfeld H: Relative changes in cerebral blood flow and neuronal activity in local microdomains during generalized seizures. J Cereb Blood Flow Metab. 2004 Sep;24 (9) :1057-68. PMID: 15356426


Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG and Behar KL: Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation. J Cereb Blood Flow Metab. 2004 Sep;24 (9) :972-85. PMID: 15356418


de Graaf RA, Mason GF, Patel AB, Rothman DL and Behar KL: Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo. Proc Natl Acad Sci U S A. 2004 Aug 24;101 (34) :12700-5. Epub 2004 Aug 13. PMID: 15310848


Shulman RG, Rothman DL, Behar KL and Hyder F: Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci. 2004 Aug;27 (8) :489-95. PMID: 15271497


Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ and Shulman GI: Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem. 2004 Jul 30;279 (31) :32345-53. Epub 2004 May 27. PMID: 15166226


Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH and Mason GF: Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry. 2004 Jul;61 (7) :705-13. PMID: 15237082


Nersesyan H, Hyder F, Rothman DL and Blumenfeld H: Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats. J Cereb Blood Flow Metab. 2004 Jun;24 (6) :589-99. PMID: 15181366


Roa DE, Song H, Yue N, d'Errico F and Nath R: Dosimetric characteristics of the Novoste Beta-Cath 90Sr/Y source trains at submillimeter distances. Med Phys. 2004 May;31 (5) :1269-76. PMID: 15191319


Petersen KF, Dufour S, Befroy D, Garcia R and Shulman GI: Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med. 2004 Feb 12;350 (7) :664-71. PMID: 14960743


Schafer JR, Fell DA, Rothman D and Shulman RG: Protein phosphorylation can regulate metabolite concentrations rather than control flux: the example of glycogen synthase. Proc Natl Acad Sci U S A. 2004 Feb 10;101 (6) :1485-90. Epub 2004 Jan 26. PMID: 14745035


Zhang XM, Patel AB, de Graaf RA and Behar KL: Determination of liposomal encapsulation efficiency using proton NMR spectroscopy. Chem Phys Lipids. 2004 Jan;127 (1) :113-20. PMID: 14706745


Mason GF and Rothman DL: Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivo. Metab Eng. 2004 Jan;6 (1) :75-84. PMID: 14734257


Liu N, Xu F, Marenco L, Hyder F, Miller P and Shepherd GM: Informatics approaches to functional MRI odor mapping of the rodent olfactory bulb: OdorMapBuilder and OdorMapDB. Neuroinformatics. 2004;2 (1) :3-18. PMID: 15067166


d'Errico F and Bos AJ: Passive detectors for neutron personal dosimetry: state of the art. Radiat Prot Dosimetry. 2004;110 (1-4) :195-200. PMID: 15353644

Patel AB, De Graaf RA, Mason GF, Rothman DL, Shulman RG and Behar KL: Coupling of glutamatergic neurotransmission and neuronal glucose oxidation over the entire range of cerebral cortex activity. Ann N Y Acad Sci. 2003 Nov;1003 :452-3. PMID: 14684486


Sanacora G, Rothman DL, Mason G and Krystal JH: Clinical studies implementing glutamate neurotransmission in mood disorders. Ann N Y Acad Sci. 2003 Nov;1003 :292-308. PMID: 14684453


Kugaya A, Sanacora G, Verhoeff NP, Fujita M, Mason GF, Seneca NM, Bozkurt A, Khan SA, Anand A, Degen K, Charney DS, Zoghbi SS, Baldwin RM, Seibyl JP and Innis RB: Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT. Biol Psychiatry. 2003 Oct 15;54 (8) :792-9. PMID: 14550678


de Graaf RA, Mason GF, Patel AB, Behar KL and Rothman DL: In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism. NMR Biomed. 2003 Oct-Nov;16 (6-7) :339-57. PMID: 14679499


Xu F, Liu N, Kida I, Rothman DL, Hyder F and Shepherd GM: Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc Natl Acad Sci U S A. 2003 Sep 16;100 (19) :11029-34. Epub 2003 Sep 8. PMID: 12963819


Price TB, Krishnan-Sarin S and Rothman DL: Smoking impairs muscle recovery from exercise. Am J Physiol Endocrinol Metab. 2003 Jul;285 (1) :E116-22. Epub 2003 Mar 11. PMID: 12637259


Krystal JH, Petrakis IL, Mason G, Trevisan L and D'Souza DC: N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther. 2003 Jul;99 (1) :79-94. PMID: 12804700


Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW and Shulman GI: Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science. 2003 May 16;300 (5622) :1140-2. PMID: 12750520


de Graaf RA and Behar KL: Quantitative 1H NMR spectroscopy of blood plasma metabolites. Anal Chem. 2003 May 1;75 (9) :2100-4. PMID: 12720347


Trübel HK, Maciejewski PK, Farber JH and Hyder F: Brain temperature measured by 1H-NMR in conjunction with a lanthanide complex. J Appl Physiol (1985). 2003 Apr;94 (4) :1641-9. Epub 2002 Nov 27. PMID: 12626478


Mason GF: Magnetic resonance spectroscopy for studies of neurotransmission in vivo. Psychopharmacol Bull. 2003 Spring;37 (2) :26-40. PMID: 14566212


Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, Berman RM and Krystal JH: Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry. 2003 Mar;160 (3) :577-9. PMID: 12611844


Shulman RG, Hyder F and Rothman DL: Cerebral metabolism and consciousness. C R Biol. 2003 Mar;326 (3) :253-73. PMID: 12806834


de Graaf RA, Brown PB, McIntyre S, Rothman DL and Nixon TW: Dynamic shim updating (DSU) for multislice signal acquisition. Magn Reson Med. 2003 Mar;49 (3) :409-16. PMID: 12594742


Mason GF, Falk Petersen K, de Graaf RA, Kanamatsu T, Otsuki T, Shulman GI and Rothman DL: A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose. Brain Res Brain Res Protoc. 2003 Feb;10 (3) :181-90. PMID: 12565689


de Graaf RA, Rothman DL and Behar KL: Adiabatic RARE imaging. NMR Biomed. 2003 Feb;16 (1) :29-35. PMID: 12577295


Hyder F, Kida I, Behar KL, Kennan RP and Rothman DL: Dominant events that modulate mass transfer coefficient of oxygen in cerebral cortex. Adv Exp Med Biol. 2003;530 :401-11. PMID: 14562735


Hyder F, Brown P, Nixon TW and Behar KL: Mapping cerebral glutamate 13C turnover and oxygen consumption by in vivo NMR. Adv Exp Med Biol. 2003;530 :29-39. PMID: 14562702


Novotny EJ Jr, Fulbright RK, Pearl PL, Gibson KM and Rothman DL: Magnetic resonance spectroscopy of neurotransmitters in human brain. Ann Neurol. 2003;54 Suppl 6 :S25-31. PMID: 12891651


Rothman DL, Behar KL, Hyder F and Shulman RG: In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol. 2003;65 :401-27. Epub 2002 May 1. PMID: 12524459


de Graaf RA, Brown PB, Mason GF, Rothman DL and Behar KL: Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy. Magn Reson Med. 2003 Jan;49 (1) :37-46. PMID: 12509818

Petroff OA, Errante LD, Rothman DL, Kim JH and Spencer DD: Neuronal and glial metabolite content of the epileptogenic human hippocampus. Ann Neurol. 2002 Nov;52 (5) :635-42. PMID: 12402262


Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL and Krystal JH: Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Arch Gen Psychiatry. 2002 Sep;59 (9) :851-8. PMID: 12215085


Kida I, Xu F, Shulman RG and Hyder F: Mapping at glomerular resolution: fMRI of rat olfactory bulb. Magn Reson Med. 2002 Sep;48 (3) :570-6. PMID: 12210928


Hyder F, Rothman DL and Shulman RG: Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI. Proc Natl Acad Sci U S A. 2002 Aug 6;99 (16) :10771-6. Epub 2002 Jul 19. PMID: 12134057


Smith AJ, Blumenfeld H, Behar KL, Rothman DL, Shulman RG and Hyder F: Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI. Proc Natl Acad Sci U S A. 2002 Aug 6;99 (16) :10765-70. Epub 2002 Jul 19. PMID: 12134056


Shulman RG, Hyder F and Rothman DL: Biophysical basis of brain activity: implications for neuroimaging. Q Rev Biophys. 2002 Aug;35 (3) :287-325. PMID: 12599751


Roa DE, Song H, Yue N, D'Errico F and Nath R: Measured TG-60 dosimetric parameters of the Novoste Beta-Cath 90Sr/Y source trains for intravascular brachytherapy. Cardiovasc Radiat Med. 2002 Jul-Dec;3 (3-4) :199-204. PMID: 12974374


Petroff OA, Errante LD, Rothman DL, Kim JH and Spencer DD: Glutamate-glutamine cycling in the epileptic human hippocampus. Epilepsia. 2002 Jul;43 (7) :703-10. PMID: 12102672


Mason GF and Rothman DL: Graded image segmentation of brain tissue in the presence of inhomogeneous radio frequency fields. Magn Reson Imaging. 2002 Jun;20 (5) :431-6. PMID: 12206869


Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P and Shulman GI: Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest. 2002 May;109 (10) :1345-50. PMID: 12021250


Sanacora G, Mason GF, Rothman DL and Krystal JH: Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry. 2002 Apr;159 (4) :663-5. PMID: 11925309


Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI and Caprio S: Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes. 2002 Apr;51 (4) :1022-7. PMID: 11916921


Kennan RP and Behar KL: Continuous-wave near-infrared spectroscopy using pathlength-independent hypoxia normalization. J Biomed Opt. 2002 Apr;7 (2) :228-35. PMID: 11966308


Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI and Petersen KF: The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 2002 Mar;51 (3) :797-802. PMID: 11872682


Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI and Rothman DL: Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci. 2002 Mar 1;22 (5) :1523-31. PMID: 11880482


Chen Q, Ma E, Behar KL, Xu T and Haddad GG: Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem. 2002 Feb 1;277 (5) :3274-9. Epub 2001 Nov 21. PMID: 11719513

Patel AB, Rothman DL, Cline GW and Behar KL: Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Res. 2001 Nov 23;919 (2) :207-20. PMID: 11701133


Hyder F, Kida I, Behar KL, Kennan RP, Maciejewski PK and Rothman DL: Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR Biomed. 2001 Nov-Dec;14 (7-8) :413-31. PMID: 11746934


Shulman RG, Hyder F and Rothman DL: Lactate efflux and the neuroenergetic basis of brain function. NMR Biomed. 2001 Nov-Dec;14 (7-8) :389-96. PMID: 11746930


Mason GF, Martin DL, Martin SB, Manor D, Sibson NR, Patel A, Rothman DL and Behar KL: Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein. Brain Res. 2001 Sep 28;914 (1-2) :81-91. PMID: 11578600


Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL and Shulman GI: Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest. 2001 Sep;108 (5) :733-7. PMID: 11544279


de Graaf RA and Rothman DL: Detection of gamma-aminobutyric acid (GABA) by longitudinal scalar order difference editing. J Magn Reson. 2001 Sep;152 (1) :124-31. PMID: 11531371


Behar KL and Rothman DL: In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine. J Nutr. 2001 Sep;131 (9 Suppl) :2498S-504S; discussion 2523S-4S. PMID: 11533301


Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS and Krystal JH: Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch Gen Psychiatry. 2001 Jun;58 (6) :556-61. PMID: 11386984


Shulman RG: Spectroscopic contributions to the understanding of hemoglobin function: implications for structural biology. IUBMB Life. 2001 Jun;51 (6) :351-7. PMID: 11758802


Shulman RG, Hyder F and Rothman DL: Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proc Natl Acad Sci U S A. 2001 May 22;98 (11) :6417-22. Epub 2001 May 8. PMID: 11344262


de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotny EJ, Hetherington HP and Rothman DL: Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab. 2001 May;21 (5) :483-92. PMID: 11333358


Petersen KF, Cline GW, Gerard DP, Magnusson I, Rothman DL and Shulman GI: Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism. 2001 May;50 (5) :598-601. PMID: 11319724


Chase JR, Rothman DL and Shulman RG: Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo 13C/31P NMR spectroscopy. Am J Physiol Endocrinol Metab. 2001 Apr;280 (4) :E598-607. PMID: 11254467


Petroff OA, Hyder F, Rothman DL and Mattson RH: Topiramate rapidly raises brain GABA in epilepsy patients. Epilepsia. 2001 Apr;42 (4) :543-8. PMID: 11440351


Rothman DL: Studies of metabolic compartmentation and glucose transport using in vivo MRS. NMR Biomed. 2001 Apr;14 (2) :149-60. PMID: 11320540


Petroff OA, Hyder F, Rothman DL and Mattson RH: Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology. 2001 Mar 27;56 (6) :709-15. PMID: 11274303


Sibson NR, Mason GF, Shen J, Cline GW, Herskovits AZ, Wall JE, Behar KL, Rothman DL and Shulman RG: In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during. J Neurochem. 2001 Feb;76 (4) :975-89. PMID: 11181817


Shulman RG and Rothman DL: The "glycogen shunt" in exercising muscle: A role for glycogen in muscle energetics and fatigue. Proc Natl Acad Sci U S A. 2001 Jan 16;98 (2) :457-61. PMID: 11209049


Shulman RG: Functional imaging studies: linking mind and basic neuroscience. Am J Psychiatry. 2001 Jan;158 (1) :11-20. PMID: 11136626


Shulman RG and Rothman DL: 13C NMR of intermediary metabolism: implications for systemic physiology. Annu Rev Physiol. 2001;63 :15-48. PMID: 11181947

Xu F, Kida I, Hyder F and Shulman RG: Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI. Proc Natl Acad Sci U S A. 2000 Sep 12;97 (19) :10601-6. PMID: 10973488


Petroff OA, Hyder F, Rothman DL and Mattson RH: Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients. Epilepsia. 2000 Jun;41 (6) :675-80. PMID: 10840398


Kida I, Kennan RP, Rothman DL, Behar KL and Hyder F: High-resolution CMR(O2) mapping in rat cortex: a multiparametric approach to calibration of BOLD image contrast at 7 Tesla. J Cereb Blood Flow Metab. 2000 May;20 (5) :847-60. PMID: 10826536


Hyder F, Renken R, Kennan RP and Rothman DL: Quantitative multi-modal functional MRI with blood oxygenation level dependent exponential decays adjusted for flow attenuated inversion recovery (BOLDED AFFAIR). Magn Reson Imaging. 2000 Apr;18 (3) :227-35. PMID: 10745130


Price TB, Laurent D, Petersen KF, Rothman DL and Shulman GI: Glycogen loading alters muscle glycogen resynthesis after exercise. J Appl Physiol (1985). 2000 Feb;88 (2) :698-704. PMID: 10658040


Krssak M, Petersen KF, Bergeron R, Price T, Laurent D, Rothman DL, Roden M and Shulman GI: Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab. 2000 Feb;85 (2) :748-54. PMID: 10690886


Petroff OA, Mattson RH and Rothman DL: Proton MRS: GABA and glutamate. Adv Neurol. 2000;83 :261-71. PMID: 10999208

Hyder F, Renken R and Rothman DL: In vivo carbon-edited detection with proton echo-planar spectroscopic imaging (ICED PEPSI): [3,4-(13)CH(2)]glutamate/glutamine tomography in rat brain. Magn Reson Med. 1999 Dec;42 (6) :997-1003. PMID: 10571918


Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS and Krystal JH: Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 1999 Nov;56 (11) :1043-7. PMID: 10565505


Price TB, Rothman DL and Shulman RG: NMR of glycogen in exercise. Proc Nutr Soc. 1999 Nov;58 (4) :851-9. PMID: 10817152


Verhoeff NP, Petroff OA, Hyder F, Zoghbi SS, Fujita M, Rajeevan N, Rothman DL, Seibyl JP, Mattson RH and Innis RB: Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRS. Epilepsia. 1999 Oct;40 (10) :1433-8. PMID: 10528940


Rothman DL, Sibson NR, Hyder F, Shen J, Behar KL and Shulman RG: In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354 (1387) :1165-77. PMID: 10466144


Cline GW, Petersen KF, Krssak M, Shen J, Hundal RS, Trajanoski Z, Inzucchi S, Dresner A, Rothman DL and Shulman GI: Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med. 1999 Jul 22;341 (4) :240-6. PMID: 10413736


Petroff OA, Hyder F, Collins T, Mattson RH and Rothman DL: Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures. Epilepsia. 1999 Jul;40 (7) :958-64. PMID: 10403220


Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS and Krystal JH: Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. Am J Psychiatry. 1999 Jun;156 (6) :952-4. PMID: 10360140


Hyder F, Petroff OA, Mattson RH and Rothman DL: Localized 1H NMR measurements of 2-pyrrolidinone in human brain in vivo. Magn Reson Med. 1999 May;41 (5) :889-96. PMID: 10332870


Novotny EJ Jr, Hyder F, Shevell M and Rothman DL: GABA changes with vigabatrin in the developing human brain. Epilepsia. 1999 Apr;40 (4) :462-6. PMID: 10219272


Petroff OA, Rothman DL, Behar KL, Hyder F and Mattson RH: Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures. Seizure. 1999 Apr;8 (2) :120-7. PMID: 10222306


Shulman RG, Rothman DL and Hyder F: Stimulated changes in localized cerebral energy consumption under anesthesia. Proc Natl Acad Sci U S A. 1999 Mar 16;96 (6) :3245-50. PMID: 10077669


Petroff OA, Hyder F, Mattson RH and Rothman DL: Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology. 1999 Feb;52 (3) :473-8. PMID: 10025774


Hyder F, Shulman RG and Rothman DL: Regulation of cerebral oxygen delivery. Adv Exp Med Biol. 1999;471 :99-110. PMID: 10659136


Petroff OA, Behar KL and Rothman DL: New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures. Adv Neurol. 1999;79 :939-45. PMID: 10514877


Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M and Shulman GI: Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999 Jan;42 (1) :113-6. PMID: 10027589


Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF and Shulman GI: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 1999 Jan;103 (2) :253-9. PMID: 9916137


Shen J, Shungu DC and Rothman DL: In vivo chemical shift imaging of gamma-aminobutyric acid in the human brain. Magn Reson Med. 1999 Jan;41 (1) :35-42. PMID: 10025609

Petroff OA, Mattson RH, Behar KL, Hyder F and Rothman DL: Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998 Dec;44 (6) :948-52. PMID: 9851440


Shen J, Novotny EJ and Rothman DL: In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train. Magn Reson Med. 1998 Nov;40 (5) :783-8. PMID: 9797163


Shulman RG and Rothman DL: Interpreting functional imaging studies in terms of neurotransmitter cycling. Proc Natl Acad Sci U S A. 1998 Sep 29;95 (20) :11993-8. PMID: 9751778


Hyder F, Shulman RG and Rothman DL: A model for the regulation of cerebral oxygen delivery. J Appl Physiol (1985). 1998 Aug;85 (2) :554-64. PMID: 9688733


Yang X, Renken R, Hyder F, Siddeek M, Greer CA, Shepherd GM and Shulman RG: Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. Proc Natl Acad Sci U S A. 1998 Jun 23;95 (13) :7715-20. PMID: 9636216


Jucker BM, Lee JY and Shulman RG: In vivo 13C NMR measurements of hepatocellular tricarboxylic acid cycle flux. J Biol Chem. 1998 May 15;273 (20) :12187-94. PMID: 9575166


Petersen KF, Laurent D, Rothman DL, Cline GW and Shulman GI: Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest. 1998 Mar 15;101 (6) :1203-9. PMID: 9502760


Petersen KF, Hendler R, Price T, Perseghin G, Rothman DL, Held N, Amatruda JM and Shulman GI: 13C/31P NMR studies on the mechanism of insulin resistance in obesity. Diabetes. 1998 Mar;47 (3) :381-6. PMID: 9519743


Shulman RG: Hard days in the trenches. FASEB J. 1998 Mar;12 (3) :255-8. PMID: 9506465


Petroff OA and Rothman DL: Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin. Mol Neurobiol. 1998 Feb;16 (1) :97-121. PMID: 9554704


Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL and Shulman RG: Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci U S A. 1998 Jan 6;95 (1) :316-21. PMID: 9419373


Shen J, Sibson NR, Cline G, Behar KL, Rothman DL and Shulman RG: 15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain. Dev Neurosci. 1998;20 (4-5) :434-43. PMID: 9778582


Sibson NR, Shen J, Mason GF, Rothman DL, Behar KL and Shulman RG: Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity. Dev Neurosci. 1998;20 (4-5) :321-30. PMID: 9778568

Rothman DL, Behar KL, Prichard JW and Petroff OA: Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magn Reson Med. 1997 Dec;38 (6) :924-9. PMID: 9402193


Yang X, Hyder F and Shulman RG: Functional MRI BOLD signal coincides with electrical activity in the rat whisker barrels. Magn Reson Med. 1997 Dec;38 (6) :874-7. PMID: 9402186


Shen J, Rycyna RE and Rothman DL: Improvements on an in vivo automatic shimming method [FASTERMAP]. Magn Reson Med. 1997 Nov;38 (5) :834-9. PMID: 9358459


Hyder F, Rothman DL, Mason GF, Rangarajan A, Behar KL and Shulman RG: Oxidative glucose metabolism in rat brain during single forepaw stimulation: a spatially localized 1H[13C] nuclear magnetic resonance study. J Cereb Blood Flow Metab. 1997 Oct;17 (10) :1040-7. PMID: 9346428


Shen J and Rothman DL: Fast automatic adjustment of on-axis shims for high-resolution NMR. J Magn Reson. 1997 Aug;127 (2) :229-32. PMID: 9281488


Hyder F, Phelps EA, Wiggins CJ, Labar KS, Blamire AM and Shulman RG: "Willed action": a functional MRI study of the human prefrontal cortex during a sensorimotor task. Proc Natl Acad Sci U S A. 1997 Jun 24;94 (13) :6989-94. PMID: 9192679


Cline GW, Magnusson I, Rothman DL, Petersen KF, Laurent D and Shulman GI: Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. J Clin Invest. 1997 May 1;99 (9) :2219-24. PMID: 9151794


Sibson NR, Dhankhar A, Mason GF, Behar KL, Rothman DL and Shulman RG: In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci U S A. 1997 Mar 18;94 (6) :2699-704. PMID: 9122259


Phelps EA, Hyder F, Blamire AM and Shulman RG: FMRI of the prefrontal cortex during overt verbal fluency. Neuroreport. 1997 Jan 20;8 (2) :561-5. PMID: 9080448


Shen J and Rothman DL: Adiabatic slice-selective excitation for surface coils. J Magn Reson. 1997 Jan;124 (1) :72-9. PMID: 9169211


Dhankhar A, Wexler BE, Fulbright RK, Halwes T, Blamire AM and Shulman RG: Functional magnetic resonance imaging assessment of the human brain auditory cortex response to increasing word presentation rates. J Neurophysiol. 1997 Jan;77 (1) :476-83. PMID: 9120588

Petroff OA, Rothman DL, Behar KL and Mattson RH: Low brain GABA level is associated with poor seizure control. Ann Neurol. 1996 Dec;40 (6) :908-11. PMID: 9007096


Petroff OA, Behar KL, Mattson RH and Rothman DL: Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy. J Neurochem. 1996 Dec;67 (6) :2399-404. PMID: 8931472


Petroff OA, Rothman DL, Behar KL, Collins TL and Mattson RH: Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology. 1996 Dec;47 (6) :1567-71. PMID: 8960747


Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, Rothman DL and Shulman GI: Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med. 1996 Oct 31;335 (18) :1357-62. PMID: 8857019


Shulman RG: Nuclear magnetic resonance studies of glucose metabolism in non-insulin-dependent diabetes mellitus subjects. Mol Med. 1996 Sep;2 (5) :533-40. PMID: 8898370


Manor D, Rothman DL, Mason GF, Hyder F, Petroff OA and Behar KL: The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA). Neurochem Res. 1996 Sep;21 (9) :1031-41. PMID: 8897466


Hyder F, Chase JR, Behar KL, Mason GF, Siddeek M, Rothman DL and Shulman RG: Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. Proc Natl Acad Sci U S A. 1996 Jul 23;93 (15) :7612-7. PMID: 8755523


Shulman RG and Rothman DL: Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proc Natl Acad Sci U S A. 1996 Jul 23;93 (15) :7491-5. PMID: 8755501


Petersen KF, West AB, Reuben A, Rothman DL and Shulman GI: Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy. Hepatology. 1996 Jul;24 (1) :114-7. PMID: 8707248


Blamire AM, Rothman DL and Nixon T: Dynamic shim updating: a new approach towards optimized whole brain shimming. Magn Reson Med. 1996 Jul;36 (1) :159-65. PMID: 8795035


Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW and Shulman GI: Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996 Jun 15;97 (12) :2859-65. PMID: 8675698


Price TB, Perseghin G, Duleba A, Chen W, Chase J, Rothman DL, Shulman RG and Shulman GI: NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. Proc Natl Acad Sci U S A. 1996 May 28;93 (11) :5329-34. PMID: 8643574


Gruetter R, Novotny EJ, Boulware SD, Rothman DL and Shulman RG: 1H NMR studies of glucose transport in the human brain. J Cereb Blood Flow Metab. 1996 May;16 (3) :427-38. PMID: 8621747


Hwang JH, Graham GD, Behar KL, Alger JR, Prichard JW and Rothman DL: Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magn Reson Med. 1996 May;35 (5) :633-9. PMID: 8722812


Petroff OA, Rothman DL, Behar KL and Mattson RH: Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology. 1996 May;46 (5) :1459-63. PMID: 8628502


Roden M, Perseghin G, Petersen KF, Hwang JH, Cline GW, Gerow K, Rothman DL and Shulman GI: The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest. 1996 Feb 1;97 (3) :642-8. PMID: 8609218


Yang X, Hyder F and Shulman RG: Activation of single whisker barrel in rat brain localized by functional magnetic resonance imaging. Proc Natl Acad Sci U S A. 1996 Jan 9;93 (1) :475-8. PMID: 8552664


Petersen KF, Price T, Cline GW, Rothman DL and Shulman GI: Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol. 1996 Jan;270 (1 Pt 1) :E186-91. PMID: 8772491


Petroff OA, Rothman DL, Behar KL, Lamoureux D and Mattson RH: The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol. 1996 Jan;39 (1) :95-9. PMID: 8572673


Shulman RG, Rothman DL and Price TB: Nuclear magnetic resonance studies of muscle and applications to exercise and diabetes. Diabetes. 1996 Jan;45 Suppl 1 :S93-8. PMID: 8529808


Taylor R, Magnusson I, Rothman DL, Cline GW, Caumo A, Cobelli C and Shulman GI: Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest. 1996 Jan 1;97 (1) :126-32. PMID: 8550823

Shulman RG, Bloch G and Rothman DL: In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proc Natl Acad Sci U S A. 1995 Sep 12;92 (19) :8535-42. PMID: 7567971


Petroff OA, Rothman DL, Behar KL and Mattson RH: Initial observations on effect of vigabatrin on in vivo 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain. Epilepsia. 1995 May;36 (5) :457-64. PMID: 7614922


Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG and Shulman GI: Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A. 1995 Feb 14;92 (4) :983-7. PMID: 7862678


Magnusson I, Rothman DL, Gerard DP, Katz LD and Shulman GI: Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration. Diabetes. 1995 Feb;44 (2) :185-9. PMID: 7859939


Hwang JH, Perseghin G, Rothman DL, Cline GW, Magnusson I, Petersen KF and Shulman GI: Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. J Clin Invest. 1995 Feb;95 (2) :783-7. PMID: 7860761


Novotny EJ Jr, Avison MJ, Herschkowitz N, Petroff OA, Prichard JW, Seashore MR and Rothman DL: In vivo measurement of phenylalanine in human brain by proton nuclear magnetic resonance spectroscopy. Pediatr Res. 1995 Feb;37 (2) :244-9. PMID: 7731764


Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG and Novotny EJ: Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab. 1995 Jan;15 (1) :12-25. PMID: 7798329


Hyder F, Rothman DL and Blamire AM: Image reconstruction of sequentially sampled echo-planar data. Magn Reson Imaging. 1995;13 (1) :97-103. PMID: 7898286

Jucker BM, Barnard ML and Shulman RG: NMR investigation of the futile cycling of ethanol in chronic alcoholic rats. Alcohol Clin Exp Res. 1994 Dec;18 (6) :1377-85. PMID: 7695033


Cline GW, Rothman DL, Magnusson I, Katz LD and Shulman GI: 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. J Clin Invest. 1994 Dec;94 (6) :2369-76. PMID: 7989593


Shulman RG, Rothman DL and Blamire AM: NMR studies of human brain function. Trends Biochem Sci. 1994 Dec;19 (12) :522-6. PMID: 7846759


Gruetter R, Novotny EJ, Boulware SD, Mason GF, Rothman DL, Shulman GI, Prichard JW and Shulman RG: Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. J Neurochem. 1994 Oct;63 (4) :1377-85. PMID: 7931289


Behar KL, Rothman DL, Spencer DD and Petroff OA: Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med. 1994 Sep;32 (3) :294-302. PMID: 7984061


Price TB, Taylor R, Mason GF, Rothman DL, Shulman GI and Shulman RG: Turnover of human muscle glycogen with low-intensity exercise. Med Sci Sports Exerc. 1994 Aug;26 (8) :983-91. PMID: 7968433


Hyder F, Behar KL, Martin MA, Blamire AM and Shulman RG: Dynamic magnetic resonance imaging of the rat brain during forepaw stimulation. J Cereb Blood Flow Metab. 1994 Jul;14 (4) :649-55. PMID: 8014212


Gruetter R, Magnusson I, Rothman DL, Avison MJ, Shulman RG and Shulman GI: Validation of 13C NMR measurements of liver glycogen in vivo. Magn Reson Med. 1994 Jun;31 (6) :583-8. PMID: 8057810


Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG and Shulman GI: Liver glycogen turnover in fed and fasted humans. Am J Physiol. 1994 May;266 (5 Pt 1) :E796-803. PMID: 8203517


Chen W, Avison MJ, Bloch G and Shulman RG: Proton NMR observation of glycogen in vivo. Magn Reson Med. 1994 May;31 (5) :576-9. PMID: 8015415


Bloch G, Chase JR, Meyer DB, Avison MJ, Shulman GI and Shulman RG: In vivo regulation of rat muscle glycogen resynthesis after intense exercise. Am J Physiol. 1994 Jan;266 (1 Pt 1) :E85-91. PMID: 8304447


Price TB, Rothman DL, Taylor R, Avison MJ, Shulman GI and Shulman RG: Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. J Appl Physiol (1985). 1994 Jan;76 (1) :104-11. PMID: 7909795


Blamire AM and Shulman RG: Implementation of echo-planar imaging on an unmodified spectrometer at 2.1 Tesla for functional imaging. Magn Reson Imaging. 1994;12 (4) :669-73. PMID: 8057772


Blamire AM, Graham GD, Rothman DL and Prichard JW: Proton spectroscopy of human stroke: assessment of transverse relaxation times and partial volume effects in single volume steam MRS. Magn Reson Imaging. 1994;12 (8) :1227-35. PMID: 7854028

Graham GD, Blamire AM, Rothman DL, Brass LM, Fayad PB, Petroff OA and Prichard JW: Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study. Stroke. 1993 Dec;24 (12) :1891-6. PMID: 8248973


Chen W, Avison MJ, Zhu XH and Shulman RG: NMR studies of 1H NOEs in glycogen. Biochemistry. 1993 Nov 2;32 (43) :11483-7. PMID: 8218214


Chen W, Novotny EJ, Zhu XH, Rothman DL and Shulman RG: Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proc Natl Acad Sci U S A. 1993 Nov 1;90 (21) :9896-900. PMID: 8234332


Chen W, Zhu XH, Avison MJ and Shulman RG: Nuclear magnetic resonance relaxation of glycogen H1 in solution. Biochemistry. 1993 Sep 14;32 (36) :9417-22. PMID: 8369311


Bloch G, Chase JR, Avison MJ and Shulman RG: In vivo 31P NMR measurement of glucose-6-phosphate in the rat muscle after exercise. Magn Reson Med. 1993 Sep;30 (3) :347-50. PMID: 8412606


Taylor R, Price TB, Katz LD, Shulman RG and Shulman GI: Direct measurement of change in muscle glycogen concentration after a mixed meal in normal subjects. Am J Physiol. 1993 Aug;265 (2 Pt 1) :E224-9. PMID: 8368292


Rothman DL, Petroff OA, Behar KL and Mattson RH: Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci U S A. 1993 Jun 15;90 (12) :5662-6. PMID: 8516315


McCarthy G, Blamire AM, Rothman DL, Gruetter R and Shulman RG: Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proc Natl Acad Sci U S A. 1993 Jun 1;90 (11) :4952-6. PMID: 8506340


Shulman RG, Blamire AM, Rothman DL and McCarthy G: Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proc Natl Acad Sci U S A. 1993 Apr 15;90 (8) :3127-33. PMID: 8475050


Behar KL, Fitzpatrick SM, Hetherington HP and Shulman RG: Cerebral metabolic studies in vivo by combined 1H/31P and 1H/13C NMR spectroscopic methods. Acta Neurochir Suppl (Wien). 1993;57 :9-20. PMID: 8421959


Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Tamborlane WV and Shulman RG: Non-invasive measurements of the cerebral steady-state glucose concentration and transport in humans by 13C nuclear magnetic resonance. Adv Exp Med Biol. 1993;331 :35-40. PMID: 8333347


Mason GF, Behar KL, Martin MA and Shulman RG: Rat brain glucose concentration and transport kinetics determined with 13C nuclear magnetic resonance spectroscopy. Adv Exp Med Biol. 1993;331 :29-34. PMID: 8333345

Blamire AM, Ogawa S, Ugurbil K, Rothman D, McCarthy G, Ellermann JM, Hyder F, Rattner Z and Shulman RG: Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci U S A. 1992 Nov 15;89 (22) :11069-73. PMID: 1438317


Petroff OA, Novotny EJ, Avison M, Rothman DL, Alger JR, Ogino T, Shulman GI and Prichard JW: Cerebral lactate turnover after electroshock: in vivo measurements by 1H/13C magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 1992 Nov;12 (6) :1022-9. PMID: 1400641


Rothman DL, Novotny EJ, Shulman GI, Howseman AM, Petroff OA, Mason G, Nixon T, Hanstock CC, Prichard JW and Shulman RG: 1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain. Proc Natl Acad Sci U S A. 1992 Oct 15;89 (20) :9603-6. PMID: 1409672


Magnusson I, Rothman DL, Katz LD, Shulman RG and Shulman GI: Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest. 1992 Oct;90 (4) :1323-7. PMID: 1401068


Gruetter R, Rothman DL, Novotny EJ, Shulman GI, Prichard JW and Shulman RG: Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain. Magn Reson Med. 1992 Sep;27 (1) :183-8. PMID: 1435204


Taylor R, Price TB, Rothman DL, Shulman RG and Shulman GI: Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med. 1992 Sep;27 (1) :13-20. PMID: 1435198


Shachar-Hill Y and Shulman RG: Co2+ as a shift reagent for 35Cl NMR of chloride with vesicles and cells. Biochemistry. 1992 Jul 14;31 (27) :6272-8. PMID: 1627566


Petroff OA, Graham GD, Blamire AM, al-Rayess M, Rothman DL, Fayad PB, Brass LM, Shulman RG and Prichard JW: Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology. 1992 Jul;42 (7) :1349-54. PMID: 1620345


Van Waarde A, Avison MJ, Thulin G, Gaudio KM, Shulman RG and Siegel NJ: Role of nucleoside uptake in renal postischemic ATP synthesis. Am J Physiol. 1992 Jun;262 (6 Pt 2) :F1092-9. PMID: 1621813


Mason GF, Behar KL, Rothman DL and Shulman RG: NMR determination of intracerebral glucose concentration and transport kinetics in rat brain. J Cereb Blood Flow Metab. 1992 May;12 (3) :448-55. PMID: 1569138


Mason GF, Rothman DL, Behar KL and Shulman RG: NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain. J Cereb Blood Flow Metab. 1992 May;12 (3) :434-47. PMID: 1349022


Gruetter R, Rothman DL, Novotny EJ and Shulman RG: Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo. Magn Reson Med. 1992 May;25 (1) :204-10. PMID: 1593953


Rothman DL, Hanstock CC, Petroff OA, Novotny EJ, Prichard JW and Shulman RG: Localized 1H NMR spectra of glutamate in the human brain. Magn Reson Med. 1992 May;25 (1) :94-106. PMID: 1350656


Rothman DL, Shulman RG and Shulman GI: 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest. 1992 Apr;89 (4) :1069-75. PMID: 1556176


Graham GD, Blamire AM, Howseman AM, Rothman DL, Fayad PB, Brass LM, Petroff OA, Shulman RG and Prichard JW: Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke. 1992 Mar;23 (3) :333-40. PMID: 1542892


Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Shulman RG and Tamborlane WV: Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proc Natl Acad Sci U S A. 1992 Feb 1;89 (3) :1109-12. PMID: 1736294

Zang LH, Howseman AM and Shulman RG: Assignment of the 1H chemical shifts of glycogen. Carbohydr Res. 1991 Nov 11;220 :1-9. PMID: 1667378


Rothman DL, Shulman RG and Shulman GI: N.m.r. studies of muscle glycogen synthesis in normal and non-insulin-dependent diabetic subjects. Biochem Soc Trans. 1991 Nov;19 (4) :992-4. PMID: 1794599


Rothman DL, Magnusson I, Katz LD, Shulman RG and Shulman GI: Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science. 1991 Oct 25;254 (5031) :573-6. PMID: 1948033


Rothman DL, Howseman AM, Graham GD, Petroff OA, Lantos G, Fayad PB, Brass LM, Shulman GI, Shulman RG and Prichard JW: Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion. Magn Reson Med. 1991 Oct;21 (2) :302-7. PMID: 1745129


Shulman RG: Is channeling a disproveable hypothesis? J Theor Biol. 1991 Sep 7;152 (1) :133-4. PMID: 1753757


Gruetter R, Prolla TA and Shulman RG: 13C NMR visibility of rabbit muscle glycogen in vivo. Magn Reson Med. 1991 Aug;20 (2) :327-32. PMID: 1775059


Avison MJ, Rothman DL, Nixon TW, Long WS and Siegel NJ: 1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man. Proc Natl Acad Sci U S A. 1991 Jul 15;88 (14) :6053-7. PMID: 2068084


Pan JW, Hamm JR, Hetherington HP, Rothman DL and Shulman RG: Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR. Magn Reson Med. 1991 Jul;20 (1) :57-65. PMID: 1943662


Pan JW, Hetherington HP, Hamm JR and Shulman RG: Quantitation of metabolites by 1H NMR. Magn Reson Med. 1991 Jul;20 (1) :48-56. PMID: 1943661


Price TB, Rothman DL, Avison MJ, Buonamico P and Shulman RG: 13C-NMR measurements of muscle glycogen during low-intensity exercise. J Appl Physiol (1985). 1991 Apr;70 (4) :1836-44. PMID: 2055862


Shulman RG, Rothman DL, Behar KL and Prichard JW: High resolution NMR studies of cerebral glucose metabolism in rats and humans. Adv Exp Med Biol. 1991;291 :5-8. PMID: 1927690

Novotny EJ Jr, Ogino T, Rothman DL, Petroff OA, Prichard JW and Shulman RG: Direct carbon versus proton heteronuclear editing of 2-13C ethanol in rabbit brain in vivo: a sensitivity comparison. Magn Reson Med. 1990 Dec;16 (3) :431-43. PMID: 2077334


David M, Petit WA, Laughlin MR, Shulman RG, King JE and Barrett EJ: Simultaneous synthesis and degradation of rat liver glycogen. An in vivo nuclear magnetic resonance spectroscopic study. J Clin Invest. 1990 Aug;86 (2) :612-7. PMID: 2117024


Zang LH, Laughlin MR, Rothman DL and Shulman RG: 13C NMR relaxation times of hepatic glycogen in vitro and in vivo. Biochemistry. 1990 Jul 24;29 (29) :6815-20. PMID: 2397215


Avison MJ, Herschkowitz N, Novotny EJ, Petroff OA, Rothman DL, Colombo JP, Bachmann C, Shulman RG and Prichard JW: Proton NMR observation of phenylalanine and an aromatic metabolite in the rabbit brain in vivo. Pediatr Res. 1990 Jun;27 (6) :566-70. PMID: 2162514


Fitzpatrick SM, Hetherington HP, Behar KL and Shulman RG: The flux from glucose to glutamate in the rat brain in vivo as determined by 1H-observed, 13C-edited NMR spectroscopy. J Cereb Blood Flow Metab. 1990 Mar;10 (2) :170-9. PMID: 1968068


Zang LH, Rothman DL and Shulman RG: 1H NMR visibility of mammalian glycogen in solution. Proc Natl Acad Sci U S A. 1990 Mar;87 (5) :1678-80. PMID: 2308928


Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA and Shulman RG: Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med. 1990 Jan 25;322 (4) :223-8. PMID: 2403659


Laughlin MR, Petit WA Jr, Shulman RG and Barrett EJ: Measurement of myocardial glycogen synthesis in diabetic and fasted rats. Am J Physiol. 1990 Jan;258 (1 Pt 1) :E184-90. PMID: 2405698

Pan JW and Shulman RG: In vivo human localized 1H spectroscopy. Magn Reson Med. 1989 Nov;12 (2) :257-8. PMID: 2559289


Behar KL, Rothman DL and Hossmann KA: NMR spectroscopic investigation of the recovery of energy and acid-base homeostasis in the cat brain after prolonged ischemia. J Cereb Blood Flow Metab. 1989 Oct;9 (5) :655-65. PMID: 2777935


Rossetti L, Rothman DL, DeFronzo RA and Shulman GI: Effect of dietary protein on in vivo insulin action and liver glycogen repletion. Am J Physiol. 1989 Aug;257 (2 Pt 1) :E212-9. PMID: 2669515


Jue T, Rothman DL, Shulman GI, Tavitian BA, DeFronzo RA and Shulman RG: Direct observation of glycogen synthesis in human muscle with 13C NMR. Proc Natl Acad Sci U S A. 1989 Jun;86 (12) :4489-91. PMID: 2734301


Fitzpatrick SM, Hetherington HP, Behar KL and Shulman RG: Effects of acute hyperammonemia on cerebral amino acid metabolism and pHi in vivo, measured by 1H and 31P nuclear magnetic resonance. J Neurochem. 1989 Mar;52 (3) :741-9. PMID: 2563756


Jue T, Rothman DL, Tavitian BA and Shulman RG: Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle. Proc Natl Acad Sci U S A. 1989 Mar;86 (5) :1439-42. PMID: 2922392


Van Waarde A, Stromski ME, Thulin G, Gaudio KM, Kashgarian M, Shulman RG and Siegel NJ: Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase. Am J Physiol. 1989 Feb;256 (2 Pt 2) :F298-305. PMID: 2537026

Stromski ME, van Waarde A, Avison MJ, Thulin G, Gaudio KM, Kashgarian M, Shulman RG and Siegel NJ: Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats. J Clin Invest. 1988 Nov;82 (5) :1694-9. PMID: 3263396


Pan JW, Hamm JR, Rothman DL and Shulman RG: Intracellular pH in human skeletal muscle by 1H NMR. Proc Natl Acad Sci U S A. 1988 Nov;85 (21) :7836-9. PMID: 3186694


Petroff OA, Prichard JW, Ogino T and Shulman RG: Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain. Neurology. 1988 Oct;38 (10) :1569-74. PMID: 3419601


Shulman GI, Rothman DL, Chung Y, Rossetti L, Petit WA Jr, Barrett EJ and Shulman RG: 13C NMR studies of glycogen turnover in the perfused rat liver. J Biol Chem. 1988 Apr 15;263 (11) :5027-9. PMID: 3128534


Avison MJ, Rothman DL, Nadel E and Shulman RG: Detection of human muscle glycogen by natural abundance 13C NMR. Proc Natl Acad Sci U S A. 1988 Mar;85 (5) :1634-6. PMID: 3422752


Laughlin MR, Petit WA Jr, Dizon JM, Shulman RG and Barrett EJ: NMR measurements of in vivo myocardial glycogen metabolism. J Biol Chem. 1988 Feb 15;263 (5) :2285-91. PMID: 3123491


Jue T, Rothman DL, Lohman JA, Hughes EW, Hanstock CC and Shulman RG: Surface coil localization of 31P NMR signals from orthotopic human kidney and liver. Proc Natl Acad Sci U S A. 1988 Feb;85 (4) :971-4. PMID: 3422493

Campbell-Burk SL, Jones KA and Shulman RG: 31P NMR saturation-transfer measurements in Saccharomyces cerevisiae: characterization of phosphate exchange reactions by iodoacetate and antimycin A inhibition. Biochemistry. 1987 Nov 17;26 (23) :7483-92. PMID: 3322400


Campbell-Burk SL, den Hollander JA, Alger JR and Shulman RG: 31P NMR saturation-transfer and 13C NMR kinetic studies of glycolytic regulation during anaerobic and aerobic glycolysis. Biochemistry. 1987 Nov 17;26 (23) :7493-500. PMID: 2962638


Jue T, Lohman JA, Ordidge RJ and Shulman RG: Natural abundance 13C NMR spectrum of glycogen in humans. Magn Reson Med. 1987 Oct;5 (4) :377-9. PMID: 3683168


Degani H, Alger JR, Shulman RG, Petroff OA and Prichard JW: 31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain. Magn Reson Med. 1987 Jul;5 (1) :1-12. PMID: 3657491


Prichard JW, Petroff OA, Ogino T and Shulman RG: Cerebral lactate elevation by electroshock: a 1H magnetic resonance study. Ann N Y Acad Sci. 1987;508 :54-63. PMID: 3439712


Shulman RG: Contributions of 13C and 1H NMR to physiological control. Ann N Y Acad Sci. 1987;508 :10-5. PMID: 3439699


Behar KL, Rothman DL, Fitzpatrick SM, Hetherington HP and Shulman RG: Combined 1H and 31P NMR studies of the rat brain in vivo: effects of altered intracellular pH on metabolism. Ann N Y Acad Sci. 1987;508 :81-8. PMID: 3125776