Topher Carroll PhD

Assistant Professor of Cell Biology

Research Interests

Epigenetics; Chromosomes; Chromatin; Gene expression; Nuclear Organization; Nuclear Membrane;


Selected Publications

  • Dynamics of CENP-N kinetochore binding during the cell cycle. Hellwig D, Emmerth S, Ulbricht T, Döring V, Hoischen C, Martin R, Samora CP, McAinsh AD, Carroll CW, Straight AF, Meraldi P, Diekmann S. J Cell Sci. 2011 Nov 15;124(Pt 22):3871-83
  • In vitro centromere and kinetochore assembly on defined chromatin templates. Guse A, Carroll CW, Moree B, Fuller CJ, Straight AF. Nature. 2011 Aug 28;477(7364):354-8
  • Dual recognition of CENP-A nucleosomes is required for centromere assembly. Carroll CW, Milks KJ, Straight AF. J Cell Biol. 2010 Jun 28;189(7):1143-55
  • Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF. Nat Cell Biol. 2009 Jul;11(7):896-902
  • Protein architecture of the human kinetochore microtubule attachment site. Wan X, O'Quinn RP, Pierce HL, Joglekar AP, Gall WE, DeLuca JG, Carroll CW, Liu ST, Yen TJ, McEwen BF, Stukenberg PT, Desai A, Salmon ED. Cell. 2009 May 15;137(4):672-84
  • An architectural map of the anaphase-promoting complex. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. Genes Dev. 2006 Feb 15;20(4):449-60
  • Centromere formation: from epigenetics to self-assembly. Carroll CW, Straight AF. Trends Cell Biol. 2006 Feb;16(2):70-8
  • Enzymology of the anaphase-promoting complex. Carroll CW, Morgan DO. Methods Enzymol. 2005;398:219-30
  • The APC subunit Doc1 promotes recognition of the substrate destruction box. Carroll CW, Enquist-Newman M, Morgan DO. Curr Biol. 2005 Jan 11;15(1):11-8
  • The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Carroll CW, Morgan DO. Nat Cell Biol. 2002 Nov;4(11):880-7

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