Titus J. Boggon, PhD

Associate Professor of Pharmacology and of Molecular Biophysics and Biochemistry

Research Interests

Molecular Biology; Signal Transduction; Hemangioma, Cavernous, Central Nervous System

Research Organizations

Molecular Biophysics and Biochemistry

Cancer Center: Signal Transduction

Structural Biology

Office of Cooperative Research

Research Summary

Cerebral Cavernous Malformations (CCM)

Normal regulation of signal transduction by the CCM proteins is lost in CCM disease. This is associated with formation of mulberry-shaped blood vessels in the brain or spine, which can have major complications [see theAngioma Alliance website]. We have determined the first crystal structures that describe each of the three CCM proteins and are using structure-directed functional approach to discover their roles and importance in signal transduction.

Rho GTPase signaling cascades

Rho family GTPases are critical regulators of actin dynamics and are important for cell proliferation, apoptosis, cell-cycle and cell adhesion. We are interested in understanding the structural biology of the signaling cascades which are regulated by Rho GTPases and the ways that these pathways are altered in disease, especially cancer. We are interested in understanding how signaling by the Rho-family member, RAC1, is altered by acquisition of a point mutation at codon 29 in melanoma. We are also interested in understanding the regulation mechanisms for downstream Rho-family effector molecules, and discovered that the type II p21-activated kinases are regulated by pseudosubstrate autoinhibition.

Integrin signaling

Integrins are transmembrane receptors that play essential roles during development, tissue formation, hemostasis, and in response to injury and infection. We are interested in the integrin-linked kinase, pinch, parvin (IPP) complex, a hub in integrin-actin and integrin-signaling networks. The IPP complex has critical roles in anchorage-dependent cell growth and survival, cell cycle progression, epithelial to mesenchymal transition, cell motility, contractility and early development. The complex is also required for cardiac, vascular, brain, kidney, muscle, skin, platelet, chondrocyte and T cell function and plays important roles in tumor angiogenesis. We are also interested in understanding how the CCM proteins interact with and impact integrin signaling.

Specialized Terms: Structural biology of signal transduction

Selected Publications

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Contact Info

Titus J. Boggon, PhD
Lab Location
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste Suite 302

New Haven, CT 06510
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Office Location
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste SHM B316A

New Haven, CT 06510
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Mailing Address
PO Box 208066
333 Cedar Street

New Haven, CT 06520-8066

Boggon Lab