Themis Kyriakides, PhD

Associate Professor of Pathology; Director Graduate Programs

Research Interests

Cell Fusion; Education, Medical; Extracellular Matrix; Foreign Bodies; Inflammation; Pathology; Wound Healing; Animal Experimentation; Nanomedicine; Translational Medical Research

Research Organizations

Pathology: Kyriakides Lab | Pathology Research

NIH T32 Program

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Summary

The main area of my research is the elucidation of the molecular events that dictate the course of healing and especially inflammation and angiogenesis following ischemia, injury and the implantation of biomaterials and scaffolds for tissue engineering applications. In collaboration with VBT colleagues we are exploring the inter-relationship between TSP2 and the Akt/eNOS signaling axis in arteriogenesis. In addition, through the process of molecular dissection of cell-matrix interactions, we aim to incorporate rational design in the development of bioengineering applications such as tissue-engineered vascular grafts. Finally, we aim to define the role of substrate nanotopography in matrix assembly and the regulation of cell-matrix interactions. Recently, we have explored the role of TSP2 in matrix assembly and have shown that the lossof TSP2 results in reduced interation with von Willebrand factor, which provides an explanation for the bleeding diathesis in TSP2 KO mice. We have also initiated studies to investigate the role of TSP2 in diabetic wound healing. In our biomedical engineering-related research we have discovered that mir-223 regulates macrophage fusion in foreign body giant cell formation and have developed a nanoparticle-based strategy to ameliorate this process on the surface of biomaterials. Finally, we have expanded our biomaterial studies to include bulk metallic glass-based implants and have explored the impact of nanotopography on cell function.

Specialized Terms: Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Tissue Engineering, Biomaterials; Nanomaterials; Bulk Metallic Glass

Extensive Research Description

Our specialized research interests include cellular and molecular events; the interface between implanted biomaterials and tissues; biomaterial-induced inflammation, wound healing, tissue engineering with a focus on angiogenesis, and extracellular matrix remodeling; in vivo work on genetically-modified mice; gene delivery from biomaterials; development of bioactive and biodegradable polymers; modification of glucose sensors; development of artificial skin.

Selected Publications

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Contact Info

Themis Kyriakides, PhD
Office Location
Department of PathologyAmistad Street Building
10 Amistad Street, Ste 301C

New Haven, CT 06519
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Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Curriculum Vitae

Kyriakides Lab