Slav Bagriantsev PhD

Assistant Professor of Cellular and Molecular Physiology

Research Interests

Sensory physiology; Biophysics; Biochemistry; Neuroscience; Electrophysiology; Polymodal ion channels; Temperature-sensitive ion channels; Mechanosensitive ion channels; Two-pore potassium channels; Ion channel pharmacology


Research Summary

Our laboratory uses a multidisciplinary approach to study the molecular basis of sensory physiology, with a focus on temperature- and mechano-transduction. We apply transcriptomics, electorphysiology, molecular biology and biochemistry to identify novel sensory molecules, and to understand the physiological roles and molecular properties of known temperature-, mechano-sensitive and polymodal ion channels.


Selected Publications

  • Bagriantsev S, Ang K, Gallardo-Godoy A, Clark K, Arkin M, Renslo A, Minor DL. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano sensitive K2P channels. ACS Chem Biol 2013, 8(8):1841-51.
  • Bagriantsev S, Clark K, Minor DL. Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains. EMBO J 2012, 31: 3297-3308.
  • Bagriantsev S, Peyronnet R, Clark K, Honore E, Minor DL. Multiple modalities converge on a common gate to control K2P channel function. EMBO J 2011, 30: 3594-3606.
  • Bagriantsev S and Minor DL. Using yeast to study potassium channel function and interactions with small molecules. Methods Mol Biol 2013, 995: 31-42.
  • Bagriantsev S, Minor DL. Small molecule ion channel match making: a natural fit for new ASIC ligands. Neuron 2010, 68(1):1-3.
  • Bagriantsev S, Gracheva EO, Richmond JE, and Liebman SW. Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition. Mol Biol Cell 2008, 19(6):2433-43.
  • Bagriantsev S, Liebman SW. Specificity of prion assembly in vivo. [PSI+] and [PIN+] form separate structures in yeast. J Biol Chem 2004, 279(49): 51042-8.

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