Stephen George Waxman, MD, PhD

Bridget M. Flaherty Professor of Neurology and Professor of Neurobiology and of Pharmacology; Director, Center for Neuroscience and Regeneration Research

Departments & Organizations

Center for Neuroscience and Regeneration Research

Interdepartmental Neuroscience Program

Neurology

Office of Student Research

Pharmacology: Neuropharmacology | Secondary Faculty

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology: Ion Channels, Pumps and Transporters; Neurobiology, Neural Networks and Neuropharmacology | Neuroscience: Neural Disorders; Neurophysiology; Sensory Systems

Biography

Stephen G. Waxman, MD, PhD

Stephen Waxman exemplifies the bridge between basic research and clinical medicine. He is the Bridget Flaherty Professor of Neurology, Neurobiology, and Pharmacology at Yale University. He served as Chairman of Neurology at Yale from 1986 until 2009. He founded and is Director of the Neuroscience & Regeneration Research Center at Yale. He also holds an appointment as Visiting Professor at University College London. Prior to moving to Yale, Dr. Waxman worked at Harvard, MIT, and Stanford.

Dr. Waxman received his BA from Harvard, and his MD and PhD degrees from Albert Einstein College of Medicine. His research, which uses tools from the “molecular revolution” to find new therapies that will promote recovery of function after injury to the brain, spinal cord, and peripheral nerves, has received international recognition.

Dr. Waxman’s research has defined the ion channel architecture of nerve fibers, and demonstrated its importance for axonal conduction (Science, 1985). He demonstrated increased expression of sodium channels in demyelinated axons (Science, 1982), identified the channel isoforms responsible for this remarkable neuronal plasticity which supports remission in multiple sclerosis (PNAS, 2004), and delineated the roles of sodium channels in axonal degeneration (PNAS, 1993). He has made pivotal discoveries that explain pain after nerve injury. Most recently, in translational leaps from laboratory to humans, he carried out molecule-to-man studies combining molecular genetics, molecular biology, and biophysics to demonstrate the contribution of ion channels to human pain (Trends in Molec.Med, 2005; PNAS, 2006), led an international coalition that identified sodium channel mutations as causes of peripheral neuropathy (PNAS, 2012) and has used atomic-level modeling to advance pharmacogenomics (Nature Comm., 2012).

Dr. Waxman has published more than 600 scientific papers. He has as edited nine books, and is the author of Spinal Cord Compression and of Clinical Neuroanatomy (translated into eight languages). He has served on the editorial boards of many journals including The Journal of Physiology, Brain, Annals of Neurology, Trends in Neurosciences, Nature Reviews Neurology, and Trends in Molecular Medicine, and is Editor-in-Chief of Neuroscience Letters. He has trained more than 150 academic neurologists and neuroscientists who lead research teams around the world.

A member of the Institute of Medicine of the National Academy of Sciences, Dr. Waxman’s many awards include the Tuve Award (NIH), the Distinguished Alumnus Award (Albert Einstein College of Medicine), the Dystel Prize and Wartenberg Award (American Academy of Neurology), and the Middleton Award of the Veterans Administration. He received the Annual Prize of the British Physiological Society, an honor he shares with his heroes, Nobel Prize laureates Andrew Huxley, John Eccles, and Alan Hodgkin. He most recently was honored with the Paul Magnuson Award of the Veterans Administration for his achievements in translation of laboratory advances into new therapeutic strategies for restoration of function after injury to the brain, spinal cord and peripheral nerves

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Education & Training

MD Albert Einstein College of Medicine (1972)
PhD Albert Einstein College of Medicine (1970)
BA Harvard University (1967)
Postdoctoral Fellow MIT
Resident Boston City Hospital
Clinical Fellow Harvard Medical School

Honors & Recognition

  • Magnuson Award for Outstanding Achievements in Rehabilitation ResearchU.S. Department of Veterans Affairs (2012)

  • W.I. McDonald Award, British Multiple Sclerosis Society (2009)

  • William S Middleton Award (highest scientific honor of the Dept of Veterans Affairs, presented at Ceremonies at the U.S. Capitol). (2009)

  • Annual Review Prize, The Physiological Society (Premier Award of the Society previous awardees include J.C. Eccles, A.F. Huxley, A.L. Hodgkin) (2009)

  • Honorary Member, Association of British Neurologists (2005)

  • Reingold Award, National Multiple Sclerosis Society (2004)

  • Dystel Prize for Research on Multiple Sclerosis, awarded jointly by the American Academy of Neurology and the Natl MS Society (2000)

  • Wartenberg Award, American Academy of Neurology (1999)

  • Honorary Senior Fellow, Institute of Neurology, London (1999)

  • Elected to Institute of Medicine, National Academy of Sciences (1996)

  • Listed in The Best Doctors in America (1994)

  • Member, Dana Alliance for Brain Initiatives (1993)

  • Distinguished Alumnus Award, Albert Einstein College of Medicine Albert Einstein Coll. of Med. (1991)

  • Fellow, Royal Society of MedicineRoyal Society of Medicine, London (1991)

  • Established Investigator, National Multiple Sclerosis Society National MS Society (1987)

  • Research Career Development Award, NINCDS NIH (1976)

  • Trygve Tuve Memorial Award for Outstanding Contributions in the Biomedical Sciences, NIH NIH (1973)

International Activity

  • PROPANE Neuropathy Genomics Project Italy (2012)

    We are the molecular neurobiology/functional genomics arm of an international project, funded by the EU, examining the genetic basis and molecular pathophysiology of painful peripheral neuropathies.

  • CRS Injury and Repair London, United Kingdom (2008)

    International Health Yale School of Medicine Yale-London collaboration in CNS injury and repair. This is a formal collaboration established by Dr. Waxman involving research on injured nervous system which takes the form of an exchange of trainees and faculty.

  • International Pain Genomics Consortium Netherlands (2008)

    Our laboratory is the hub for studies on rare families, from throughout the world, with mutations of ion channels that produce a pain phenotype. We have major collaborations with University of Radboud, Netherlands; University of Maastrich, Netherlands; and Beijing University

  • Editor, Journal of Physiology United Kingdom (2005 - 2012)

    Editor, Journal of Physiology

  • Visiting Professor of Anatomy, Biology, and Clinical Neurology, University College London (1998)

    Visiting Professor of Anatomy, Biology, and Clinical Neurology, University College London

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Contact Info

Stephen George Waxman, MD, PhD
Office Location
Center for Neuroscience & Regeneration ResearchVA Connecticut Healthcare
950 Campbell Avenue, Ste BLDG. 34

West Haven, CT 06516
Mailing Address
Neurosci. Res. Ctr. (BLDG. 34)VA Hospital
950 Campbell Ave

West Haven, CT 06516

Curriculum Vitae

Waxman Lab/Center for Neuroscience & Regeneration Research