Stephen M Strittmatter MD, PhD

Vincent Coates Professor of Neurology and Professor of Neurobiology; Director, Cellular Neuroscience, Neurodegeneration and Repair; Director, Memory Disorders Clinic

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Cell Biology, Genetics and Development

Program in Cellular Neuroscience, Neurodegeneration and Repair

Interdepartmental Neuroscience Program

Neurobiology: Kavli Institute for Neuroscience | Strittmatter Lab

Neurology: Alzheimer's Disease/Dementia and Neuro-degenerative Disorders

National Gaucher Disease Treatment Center

Research Interests

Axon Guidance; Axon Regeneration; Spinal Cord Injury; Molecular Biology; Stroke; Neurodegenerative Disease; Alzheimer's Disease; Fronto-Temporal Dementia more...


  • AB, Harvard College, 1980
  • M.D., Johns Hopkins University, 1986
  • Ph.D., Johns Hopkins University, 1986

Selected Publications

  • Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM. Metabotropic Glutamate Receptor 5 is a Co-Receptor for Alzheimer Aß Oligomer Bound to Cellular Prion Protein. Neuron, 79:887-902 (2013).
  • Akbik FV, Bhagat SM, Patel PR, Cafferty WB, Strittmatter SM. Anatomical plasticity of adult brain is titrated by nogo receptor 1. Neuron. 6:859-866 (2013).
  • Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC, Strittmatter SM. Alzheimer Amyloid-ß Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons. Nat Neurosci. 15: 1227-1235 (2012).



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