Stephen M Strittmatter, MD, PhD

Vincent Coates Professor of Neurology and Professor of Neuroscience; Director, Cellular Neuroscience, Neurodegeneration and Repair; Director, Memory Disorders Clinic; Director, Yale Alzheimer's Disease Research Center

Research Interests

Alzheimer Disease; Axons; Dementia; Spinal Cord Injuries; Motor Neuron Disease; Regenerative Medicine

Research Organizations

Neurology: Alzheimer's Disease Research Center (ADRC) | Strittmatter Lab

Interdepartmental Neuroscience Program

Program in Cellular Neuroscience, Neurodegeneration and Repair

Office of Cooperative Research

Research Summary

Neural Repair and Neuro-Degeneration

Neurological injury frequently interrupts connections while sparing nerve cells. Spinal Cord Injury (SCI) is the epitome of a disconnection syndrome, in which surviving neural tissue fails to function due to lost communication at the level of injury. For the organism to regain function, new pathways must form by growth of cut or surviving nerve fibers. Unfortunately, the growth of axons and the rearrangement of brain circuitry are extremely limited in the adult brain and spinal cord.

We focus on understanding the molecular pathways that limit fiber growth and functional rewiring of neuronal circuits during health and disease. Axonal growth encompasses both neural plasticity and repair. Technically, we utilize chronic in vivo imaging of neuronal connections, genetic alteration of mice and induction of surgical lesions resembling clinical SCI and Stroke. In particular, we have found that the NogoReceptor (NgR1) pathway mediating myelin inhibition of axonal growth plays a role in titrating anatomical plasticity in the adult CNS.

In Alzheimer's Disease and several other neurodegenerative conditions, nerve cells are lost over time. Molecular contributors to this pathology have been discovered by genetic methods, but their mechanism of action has remained poorly understood. We have focused on defining the pathophysiological action of Amyloid-beta (Aß) peptide oligomers in Alzheimer's Disease, and on the role of secreted Progranulin in Fronto-Temporal Dementia. For both of these molecules, interaction with the specific receptors on the neuronal surface is crucial. We utilize receptor ligand binding assays, expression cloning, electrophysiology, genetics and mouse behavior to study these pathways.

Selected Publications

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Contact Info

Stephen M Strittmatter, MD, PhD
Patient Care Location
Yale Memory ClinicYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Lab Location
Boyer Center for Molecular Medicine
295 Congress Avenue, Ste 431-435

New Haven, CT 06510
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Mailing Address
CNNR Program295 Congress Ave.
New Haven, CT 06536

Strittmatter Laboratory

Amyloid Beta and Neurons

Oligomeric Beta-Amyloid Binding to Cultured Hippocampal Neurons.

Spinal Cord Injury

Raphespinal Axon Regeneration after Spinal Cord Transection in Mice Lacking Nogo Receptor.

Mouse Model of Alzheimer

In a mouse model of Alzheimer’s disease, amyloid beta clusters (red) build up among neurons (green) in a memory-related area of the brain.