Sabrina Diano PhD
Professor of Obstetrics, Gynecology, and Reproductive Sciences, of Comparative Medicine and of Neurobiology; Director, Reproductive Neurosciences Group
Sabrina Diano, Ph.D.
Dr. Sabrina Diano is a Tenure Professor in Departments of OB/GYN & Reproductive Sciences, Neurobiology and Comparative Medicine at the Yale University School of Medicine. She is also part of the Integrative Cell Signaling and Neurobiology of Metabolism (ICSNM), and Interdepartmental Neuroscience Program here at Yale. She graduated with honors from the University of Naples “Federico II”, Naples, Italy. She conducted her post doctoral studies here at Yale where she became faculty in 2000.
Her research focuses on CNS (hypothalamic) mechanisms relating to the regulation of energy homeostasis, with emphasis on hormone action in the hypothalamus. Her studies on hypothalamic inter- and intra-cellular mechanisms that regulates energy metabolism add critical information to the current understanding of the central regulation of energy balance and how alterations in stored energy are sensed in the hypothalamus. The results of her research have important implications for understanding the pathogenesis of metabolic syndrome, obesity and type 2 diabetes, disorders that are the leading cause of morbidity and mortality in the U.S., and the developed world in general, with the highest financial burden on the National economy.
Jeong JK, Diano S (2013) Prolyl carboxypeptidase and its inhibitors in metabolism. Trend in Endocrinology and Metabolism in press.
D'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S (2012) Cerebral Cortex
Diano S, Horvath TL (2012) Mitochondrial uncoupling protein 2 in glucose and lipid metabolism. Trends in Molecular Medicine 18(1):52-8.
Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett A, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL (2011) Peroxisome proliferation-related hypothalamic control of ROS sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine 2011 17(9):1121-7.
Diano S, Horvath TL. (2010) A sympathetic view on free radicals in diabetes. Neuron 66(6):809-11.
Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, Diano S. (2009) Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. J Clin Invest. 119(8):2291-303.
Andrews ZB, Liu ZW, Wallingford N, Erion DM, Borok E, Friedman JM, Tschoep MH, Shanabrough M, Cline GM, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S (2008) UCP2 mediates ghrelin’s action on NPY/AgRP neurons. Nature 454(7206):846-51.
Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. (2007) Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine. 13(1):89-94.
Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, HorvathTL, Gao XB, Diano S. (2007) A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metabolism 5:21-33.
Diano S, Farr SA, Benoit SC, Mcnay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Xu L, Banks WA, Morley JE, Pinto S, Sherwin RS, Yamada KA, Sleeman MW, Tschöp MH, Horvath TL. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience 9(3):381-8.
Education & Training
- University of Naples, Italy (1993)