Robert Henry Roth, Jr, PhD

Professor of Psychiatry and of Pharmacology

Research Interests

Behavior and Behavior Mechanisms; Mental Disorders; Central Nervous System Diseases; Parkinson Disease; Psychiatry and Psychology; Phenomena and Processes

Research Organizations

Interdepartmental Neuroscience Program

Neuropharmacology

Psychiatry: Neural Transplant and Neurobehavior Program

Research Summary

Our laboratory takes a neurochemical approach towards examining neurotransmitter function and the mechanism of action of psychotropic drugs. The major research investigates the biochemical organization, regulatory control, pharmacology, and function of catecholamine-containing neurons in the CNS. We also investigate the post-translational mechanisms by which neuronal impulse flow regulates tyrosine hydroxylase and examine the function of dopamine autoreceptors. Our focus recently has been on central dopamine systems and, in particular, on the mesocortical system. These studies, carried out both in rodents and non-human primates, have revealed that the mesotelencephalic dopamine systems are quite heterogeneous, exhibiting distinct physiological and pharmacological properties. Neural grafting is another research interest of our lab. We are currently investigating the function of neural grafts and stem cells in the MPTP primate model of Parkinson’s disease.

Selected Publications

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