Richard Baxter Ph.D.
Assistant Professor of Chemistry and of Molecular Biophysics and Biochemistry
The Baxter lab is interested in the innate immune response of
arthropods, especially the complement-like system in Anopheles gambiae,
host-pathogen interactions, and the development of new chemical entities
for the control of vector-borne disease. Our primary research tools are
biophysical methods, including macromolecular crystallography and
small-angle x-ray scattering, biochemistry and chemical biology. Our
approach is multi-disciplinary and interfaces with both cross-campus and
international collaborators studying vector biology and infectious disease.
- 4. Baxter, R.H.G., Chang, C.-I., Chelliah, Y.C., Blandin, S., Levashina, E.A., Deisenhofer, J. (2007) "Structural basis for conserved complement factor-like function in the antimalarial protein TEP1" Proc. Natl. Acad. Sci. USA 104, 11615-11620. [PMID 17606907]
- 3. Fraiture, M., Baxter, R.H.G., Steinert, S., Chelliah, Y., Frolet, C., Quispe-Tintaya, W., Hoffmann, J., Blandin, S., Levashina, E. (2009) "Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium" Cell Host Microbe 5, 273-284. [PMID 19286136]
- Baxter, R.H.G., Volohonsky, G., Chelliah, Y., Steinert, S., Levashina, E.A., Deisenhofer J. (2010) “A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae”, Proc. Natl. Acad. Sci. USA 107, 16817-16822. [PMID 20826443]