Molecular Cell Biology, Genetics, and Development Faculty

Murat Acar

Assistant Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Systems biology, synthetic biology, gene regulatory networks, noise in gene expression, aging, evolution of gene networks.

Herve Agaisse

Associate Professor of Microbial Pathogenesis

Research Interests:Host/pathogen interaction, microorganisms; infection; cell-to-cell spread; Listeria; Shigella; Chlamydia; Rickettsia; Vaccinia; Drosophila melanogaster; immune response; stem cells; JAK/STAT signaling; aging

Peter Aronson

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology

Research Interests:Urinary electrolyte excretion; cell membrane ion exchangers; proximal tubule

Allen Bale

Professor of Genetics
Director, DNA Diagnostic Lab

Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor

Susan Baserga

Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology

Research Interests:Ribosome biogenesis; rRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing

Anton Bennett

Associate Professor of Pharmacology and of Comparative Medicine
Co-Director, Program in Integrative Cell Signaling and Neurobiology of Metabolism
Director, BBS Minority Affairs

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

Joerg Bewersdorf

Assistant Professor of Cell Biology and of Biomedical Engineering

Research Interests:Super-resolution fluorescence microscopy

Jonathan Bogan

Associate Professor of Medicine (Endocrinology) and of Cell Biology

Research Interests:Protein trafficking; ubiquitin-like modification; cell structure; insulin signaling; type 2 diabetes; metabolic diseases

Titus Boggon

Associate Professor of Pharmacology

Research Interests:Structural biology of signal transduction

Alfred Bothwell

Professor of Immunobiology
Director of Graduate Studies

Research Interests:Human T cell recognition; inflammation and cancer; type 1 diabetes; function of PPARs

Emile Boulpaep

Professor of Cellular and Molecular Physiology
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology

Research Interests:Electrical properties of membrane proteins in plasma membranes and junctions of renal tubule cells

Douglas Brash

Senior Research Scientist in Therapeutic Radiology and Professor of Dermatology and of Genetics and Clinical Professor of Therapeutic Radiology

Research Interests:Ultraviolet Light; Skin Cancer

Ronald Breaker

Henry Ford II Professor of Molecular, Cellular, and Developmental Biology
Investigator, Howard Hughes Medical Institute

Research Interests:non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA's role in evolution

Thomas Brown

Professor of Psychology and of Cellular and Molecular Physiology

Research Interests:Neurobiological mechanism of learning and memory.

Gary Brudvig

Eugene Higgins Professor of Chemistry and Professor of Molecular Biophysics and Biochemistry

Research Interests:photosystem II; EPR spectroscopy; metalloproteins; artificial photosynthesis

Martina Brueckner

Associate Professor of Pediatrics (Cardiology) and of Genetics

Research Interests:Development of left-right asymmetry; Heterotaxy syndrome; Kartagener syndrome; Situs inversus

Christopher Burd

Associate Professor of Cell Biology

David Calderwood

Associate Professor of Pharmacology and of Cell Biology

Research Interests:Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology

Cecilia Canessa

Professor of Cellular and Molecular Physiology and of Medicine (Nephrology)

Research Interests:Renal Function; Epithelial Sodium Channels

Michael Caplan

C. N. H. Long Professor of Cellular and Molecular Physiology and Professor of Cell Biology
Chair, Cellular and Molecular Physiology

Research Interests:Ion pumps in polarized epithelia; Sorting and function

John Carlson

Eugene Higgins Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Drosophila, olfaction, taste, Anopheles, mosquito

Topher Carroll

Assistant Professor of Cell Biology

Research Interests:Epigenetics; Chromosomes; Chromatin; Gene expression; Nuclear Organization; Nuclear Membrane;

Sreeganga Chandra

Assistant Professor of Neurology and of Molecular, Cellular, and Developmental Biology

Research Interests:Presynaptic Biology; Synapse Maintenance; Parkinson's Disease; Neurodegeneration

Kei-Hoi Cheung

Associate Professor of Anesthesiology (Medical Informatics) and of Genetics

Research Interests:Genetic database and tool interpolation

Tian Chi

Associate Professor of Immunobiology

Research Interests:Epigenetic memory; transgenerational inheritance; chromatin biology

Judy Cho

Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and Professor of Genetics and of Pediatrics (Gastroenterology)
Director, Inflammatory Bowel Disease Center

Research Interests:Inflammatory Bowel Disease (IBD); identifying genetic variation that affects susceptibility to and expression of Inflammatory Bowel Disease (IBD)

Damon Clark

Assistant Professor of Molecular, Cellular, and Developmental Biology and Residential College Associate Fellow in Faculty of Arts and Sciences

Nicole Clay

Assistant Professor of Molecular, Cellular, and Developmental Biology

Daniel Colon-Ramos

Assistant Professor of Cell Biology

Research Interests:Neural connectivity; Brain; Nematode C. elegans

Lynn Cooley

C. N. H. Long Professor of Genetics and Professor of Cell Biology and of Molecular, Cellular, and Developmental Biology
Director, Combined Program in the Biological & Biomedical Sciences

Research Interests:Molecular Genetics of Drosophila Oogenesis; Actin Cytoskeleton Regulation; Drosophila; Oogenesis; Ring Canal; Ovarian Muscle Function

Chris Cotsapas

Assistant Professor of Neurology and of Genetics

Research Interests:We use genetics, computational biology and cell-based approaches to discover and understand the mechanisms that give rise to disease. We are particularly interested in disorders of the immune system and brain.

Peter Cresswell

Eugene Higgins Professor of Immunobiology and Professor of Cell Biology and of Dermatology

Research Interests:Molecular mechanisms of antigen processing; assembly and intracellular transport of CD1 molecules, class I and class II MHC molecules; effector functions and mechanisms of action of interferon-induced proteins; viral immunity

Craig Crews

Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry and of Pharmacology
Executive Director, Yale Molecular Discovery Center

Research Interests:Limb regeneration; wound epidermis; blastema; natural product mode of action studies; angiogenesis; Wnt signaling; protein turnover; protein kinase regulation

Pietro De Camilli

Eugene Higgins Professor of Cell Biology and Professor of Neurobiology
Director, Yale Program in Cellular Neuroscience and Neurodegeneration and Repair
Investigator, Howard Hughes Medical Institute

Research Interests:Synapses; exocytosis; endocytosis; membranes; clathrin; dynamin; phosphoinositides; Lowe syndrome; BAR proteins; neurodegeneration

Enrique De La Cruz

Professor of Molecular Biophysics and Biochemistry

Research Interests:Cytoskeleton; RNA helicases; Kinetics; Thermodynamics; Polymer Mechanics; Processivity

Stephen Dellaporta

Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Functional genomics; plant molecular genetics; marine genomics; biofuels

Xing Wang Deng

Daniel C. Eaton Professor of Molecular, Cellular, and Developmental Biology
Daniel C. Eaton Professor of Plant Biology at Yale
Director of Peking-Yale Center for Plant Molecular Genetics & Agrobiotechnology

Research Interests:Plant Biology, Genome and Epigenome, Development mechanism, Hybrid Vigor, Agribiotechnology Light Regulation

Michael DiGiovanna

Associate Professor of Medicine (Medical Oncology) and of Pharmacology

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; estrogen receptor, signal transduction

Ralph DiLeone

Associate Professor of Psychiatry and of Neurobiology

Research Interests:Addictions; Animal Behavior; Ethology; Animal Nutrition; Diseases and Disorders; Drug Abuse; Eating Disorders; Etiology; Evolution; Genetic Manipulation; Natural History; Obesity; Psychiatry

Daniel DiMaio

Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Scientific Director, Yale Cancer Center
Deputy Director, Yale Cancer Center

Research Interests:Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence ; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus

Thierry Emonet

Associate Professor of Molecular, Cellular, and Developmental Biology and of Physics

Research Interests:Computational Biology chemotaxis, olfaction, immunology

Shawn Ferguson

Assistant Professor of Cell Biology

Research Interests:lysosomes; membrane traffic; energy homeostasis; nutrient homeostasis; transcription factor; signaling; neurodegeneration; neuronal ceroid lipofuscinosis; genetics

Biff Forbush

Professor of Cellular and Molecular Physiology

Research Interests:Membrane Proteins; Epithelial Transport; Ion Transport; Na-K-Cl Cotransporter; Nerve Cells; Muscle Cells

Paul Forscher

Professor of Molecular, Cellular, and Developmental Biology

Research Interests:cytoskeleton; actin filament; microtubule; protein dynamics; axon growth; axon guidance; axon regeneration; mechanotransduction; calcium; Rho GTPase

Jorge Galan

Lucille P. Markey Professor of Microbial Pathogenesis and Professor of Cell Biology
Chair, Department of Microbial Pathogenesis

Research Interests:Microbial Pathogenesis; host/pathogen interaction

Patrick Gallagher

Professor of Pediatrics (Neonatology), of Genetics and of Pathology
Director, Yale Center for Blood Disorders
Director, Expression and Genomics Core, Yale Center of Excellence in Molecular Hematology

Research Interests:Neonatal hematology; Erythropoiesis; Inherited abnormalities of the erythrocyte including metabolic, membrane, and hemoglobin disorders; Sickle cell disease; Hereditary spherocytosis; Elliptocytosis; Pyropoikilocytosis; Stomatocytosis

Martin Garcia-Castro

Associate Professor of Molecular, Cellular, and Developmental Biology

Joel Gelernter

Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neurobiology
Director, Division of Human Genetics (Psychiatry)

Research Interests:Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Gene mapping

Mark Gerstein

Albert L. Williams Professor of Biomedical Informatics
Co-Director, Yale Computational biology and Bioinformatics Program

Research Interests:Biochemistry; Bioinformatics; Biophysics; Computational Biology; DNA; Genomics; Molecular Simulation; Proteins; Sequence Alignment; Structural Biology

Antonio Giraldez

Associate Professor of Genetics
Member of the Yale Cancer Center
Member of the Stem Cell Center
Director of Graduate Studies

Research Interests:Non-coding RNAs, Post-transcriptional regulation; microRNAs; Developmental Biology; Gene regulatory networks; Systems Biology; Zebrafish

Peter Glazer, MD, PhD

Robert E. Hunter Professor of Therapeutic Radiology and Professor of Genetics
Chair, Department of Therapeutic Radiology

Research Interests:Gene targeting and gene therapy; Genetic instability in cancer; Mutagenesis; DNA repair; Radiation resistance; Cellular responses to radiation

Andrew Goodman

Assistant Professor of Microbial Pathogenesis

Research Interests:Microbiota; Microbiome; Genomics; Gnotobiotic; Germfree; Symbiosis; Gut; Flora; Bacteria; Pathogen

Fred Gorelick

Professor of Medicine (Digestive Diseases) and of Cell Biology
Associate Director, Yale M.D., Ph.D. Program

Research Interests:Exocrine pancreas; pancreatitis; intracellular proteolysis; vacuolar ATPase; AMPK; protein kinase C

Valentina Greco

Assistant Professor of Genetics and of Dermatology

Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; cancer

Eduardo Groisman

Professor of Microbial Pathogenesis and Residential College Associate Fellow in Faculty of Arts and Sciences
HHMI Investigator

Research Interests:bacterial genetics; signal transduction; infectious diseases; gene regulation; bacteria-host interactions; gut commensal bacteria

Jeffrey Gruen

Professor of Pediatrics (Neonatology) and of Genetics

Research Interests:Complex inherited traits including bladder exstrophy; Genetic susceptibility to newborn disorders; Genetics of reading disability (dyslexia)

Murat Gunel

Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neurobiology
Co-Director, Yale Program on Neurogenetics
Director, Neurovascular Surgery

Research Interests:Molecular genetics and biology of brain aneurysms and cavernous malformations; molecular genetics of brain development

Marc Hammarlund

Assistant Professor of Genetics

Research Interests:Axon regeneration and degeneration; Neuronal plasticity; Femtosecond laser surgery; C. elegans neurobiology

Jo Handelsman

Professor of Molecular, Cellular, and Developmental Biology
Frederick Phineas Rose Professor
Howard Hughes Medical Institute Professor

Carl Hashimoto

Professor of Cell Biology

Research Interests:Proteolysis; serpins; intercellular signaling; morphogenesis; disease modeling; Drosophila molecular genetics

Shilpa Hattangadi

Assistant Professor of Pediatrics (Hematology / Oncology) and of Pathology
Assistant Professor, Pathology

Research Interests:Terminal erythroid development, hematopoiesis; bone marrow failure; red cell aplasia; chromatin condensation; nuclear protein export; proteomics; genomics; transcriptional regulation; histone modification; post-transcriptional modification of hematopoietic regulators

Michael Higley

Assistant Professor of Neurobiology
Primary Member, Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR)
Member, Kavli Institute fir Neuroscience

Research Interests:Synaptic integration; GABAergic interneurons; Inhibition; 2-photon; Electrophysiology

Mark Hochstrasser

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

Scott Holley

Associate Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Somitogenesis, Body Elongation, Morphogenesis, Developmental Gene Networks, Embryo Biomechanics

Valerie Horsley

Assistant Professor of Molecular, Cellular, and Developmental Biology and of Dermatology

Arthur Horwich

Sterling Professor of Genetics and Professor of Pediatrics
and Investigator HHMI

Research Interests:Chaperones in protein folding; ALS (Lou Gehrig's Disease)

Michael Hurwitz

Assistant Professor of Medicine (Medical Oncology)

Research Interests:Cell migration; Kinase signaling; Phosphorylation; Cytoskeleton; Engulfment; Apoptosis; C. elegans; Cancer biology

Vivian Irish

Professor of Molecular, Cellular, and Developmental Biology and of Ecology and Evolutionary Biology

Research Interests:developmental genetics; Arabidopsis; evolution of development

Farren Isaacs

Assistant Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Synthetic Biology; Systems Biology; Genomics; Biotechnology

Natalia Ivanova

Assistant Professor of Genetics

Research Interests:Embryonic and somatic stem cells; Vertebrate development; Functional genomics; Systems biology

Akiko Iwasaki

Professor of Immunobiology and of Molecular, Cellular, and Developmental Biology
Professor of Molecular Cellular and Developmental Biology
Howard Hughes Medical Investigator

Research Interests:Innate immunity; Autophagy; Inflammasomes; sexually transmitted infections; Herpes simplex virus; human papillomavirus;respiratory virus infections; Influenza infection; T cell immunity; Commensal bacteria

Christine Jacobs-Wagner

Professor of Molecular, Cellular, and Developmental Biology and of Microbial Pathogenesis
HHMI Investigator

Research Interests:Cell division; chromosome segregation; cell cycle coordination; cell morphogenesis, cytokeleton, cell polarity

Samuel Katz

Assistant Professor of Pathology

Paula Kavathas

Professor of Laboratory Medicine, of Genetics, of Immunobiology and of Molecular, Cellular, and Developmental Biology
Associate Chair for Research
Director, Science Education Outreach Program

Research Interests:Gene Regulation; Immunology; Molecular Cellular Entities; Receptors; Structure or Function (Health or Safety or Medical); Transgenic Animals

Barbara Kazmierczak

Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis
Associate Director for Basic Research, MD-PhD Program, Yale University

Research Interests:Pseudomonas aeruginosa; Staphylococcus aureus; innate immunity; host-pathogen interactions; mucosal immunity

Haig Keshishian

Professor of Molecular, Cellular, and Developmental Biology

Mustafa Khokha

Associate Professor of Pediatrics (Critical Care) and of Genetics

Research Interests:Establishment of vertebrate body plan; Embryonic patterning and gene regulatory networks; Xenopus (frog) genetics

Kenneth Kidd

Professor of Genetics, of Ecology and Evolutionary Biology and of Psychiatry

Research Interests:Complex Human Disorders; Neuropsychiatric Disorders; Human Population ; Genetics; Human Evolution

In-Jung Kim

Assistant Professor of Ophthalmology and Visual Science and of Neurobiology

Research Interests:Neuroscience; Development; Visual System; Neural Circuits; Transgenic approaches; Direction Selectivity

Tae Hoon Kim

Assistant Professor of Genetics
Member, Yale Cancer Center
Member, Yale Stem Cell Center

Research Interests:Transcriptional Regulatory Elements and Chromatin Structure; Expression of the Cancer Genome; Epigenomics

Megan King

Assistant Professor of Cell Biology

Research Interests:microtubules; nucleus; nuclear envelope; DNA repair; cellular mechanics; telomere biology

Michael Koelle

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:C. Elegans; G Protein; Neurotransmission; RGS Protein; Serotonin; Molecular Genetics; Neurobiology; Neurotransmitters; Proteins and Macromolecules; Receptors

Anthony Koleske

Professor of Molecular Biophysics and Biochemistry and of Neurobiology

Research Interests:Neuronal morphogenesis and degeneration; stress; schizophrenia; cell migration; cancer; metastasis; adhesion receptors

William Konigsberg

Professor of Molecular Biophysics and Biochemistry

Research Interests:Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules

Diane Krause

Professor of Laboratory Medicine, of Cell Biology and of Pathology
Assoc. Director, Yale Stem Cell Center
Assoc. Director, Transfusion Medicine Service
Director, Frisbee Laboratory for Hematopoietic Graft Engineering

Research Interests:Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia

Gary Kupfer

Professor of Pediatrics (Hematology / Oncology) and of Pathology
Clinical Program Leader, Pediatric Hematology & Oncology Program, Smilow Cancer Hospital
Section Chief, Pediatric Hematology/Oncology
Clinical Research Program Leader, Pediatric Hematology & Oncology Program, Yale Cancer Center

Research Interests:Genomic instability; Development of cancer; Genetic syndrome Fanconi anemia (FA); Viral protein enhancement of cancer therapeutics

Themis Kyriakides

Associate Professor of Pathology and of Biomedical Engineering

Research Interests:Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Gene delivery; Biomaterials

Peining Li

Associate Professor of Genetics

Research Interests:Cytogenetic and genomic analysis; Dissection of genetic mechanisms for growth regulation, mental development, and cancer progression

Richard Lifton

Sterling Professor of Genetics and Professor of Medicine (Nephrology)
Chair, Department of Genetics
Investigator, Howard Hughes Medical Institute

Research Interests:Molecular genetics of common human diseases

Janghoo Lim

Assistant Professor of Genetics

Research Interests:Mechanisms of neural development, neurological disorders, and neurodegenerative diseases

Chenxiang Lin

Assistant Professor of Cell Biology

Research Interests:Engineering DNA-nanostructure-based molecular tools for biological study

Haifan Lin

Professor of Cell Biology and of Genetics
Director, Yale Stem Cell Center

Research Interests:RNA-mediated epigenetic programming and post-transcriptional regulation of stem cells

Jun Lu

Assistant Professor of Genetics

Research Interests:Non-coding RNAs in blood stem cell differentiation and malignancies; MicroRNA-mediated control of embryonic stem cell fates; MicroRNA mechanisms

Patrick Lusk

Assistant Professor of Cell Biology

Research Interests:nuclear pore complex; nuclear periphery; membrane proteins; chromatin structure

Joseph Madri

Professor of Pathology
Director of Education

Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell-Endothelial cell interactions

Arya Mani

Associate Professor of Medicine (Cardiology) and of Genetics
Director, Cardiovascular Genetics Program

Research Interests:Identification of cardiovascular disorders that have strong familial pattern

Malaiyalam Mariappan

Assistant Professor of Cell Biology

Research Interests:Membrane protein homeostasis; Membrane protein targeting and insertion; Membrane protein assembly; Misfolded membrane protein degradation; Biochemical reconstitution

Ruslan Medzhitov

David W. Wallace Professor of Immunobiology
Investigator, Howard Hughes Medical Institute

Research Interests:Inflammation; Allergy; Immunology; Innate Immunity; Pathophysiology

Thomas Melia

Assistant Professor of Cell Biology

Research Interests:Macroautophagy; autophagy

Perry Miller

Professor of Anesthesiology (Medical Informatics)

Research Interests:Biomedical informatics; Clinical informatics; Bioinformatics; Neuroinformatics

Kathryn Miller-Jensen

Assistant Professor of Biomedical Engineering and of Molecular, Cellular, and Developmental Biology

Mark Mooseker

Ross Granville Harrison Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology
and Pathlogy

Research Interests:The cytoskeleton. Epithelial cell biology. molecular motors

Jon Morrow

Raymond Yesner Professor of Pathology
Chair, Department of Pathology
Chief of Pathology at YNHH

Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

Walther Mothes

Associate Professor of Microbial Pathogenesis

Research Interests:cell biology; retroviral replication; retroviruses; immune; viral biology; genetic; biochemical; cell imaging; Viral entry and exit; Retroviruses including HIV

Michael Nathanson

Professor of Medicine (Digestive Diseases) and of Cell Biology
Section Chief, Digestive Diseases
Director, Yale Liver Center
Director, Center for Cell and Molecular Imaging

Research Interests:Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus

Timothy Nelson

Professor of Molecular, Cellular, and Developmental Biology
Director, Marsh Botanical Garden

Research Interests:Arabidopsis; Zea mays; vascular patterning

Don Nguyen

Assistant Professor of Pathology

Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

Michael Nitabach

Associate Professor of Cellular and Molecular Physiology and of Genetics

Research Interests:Neurophysiology; Molecular genetics; Systems Physiology; Animal Behavior

James Noonan

Assistant Professor of Genetics
Member, Kavli Institute for Neuroscience
Member, Yale Cancer Center

Research Interests:Human Evolution; Evolutionary Dynamics of Gene Regulation; Synthetic Biology; Applications of Ultra-High Throughput Sequencing Technologies; Comparative and Functional Genomics in Vertebrates

In-Hyun Park

Assistant Professor of Genetics
Yale Stem Cell Center

Research Interests:Reprogramming; iPS cells; neurodevelopment; epigenetics

Katerina Politi

Assistant Professor of Medicine (Medical Oncology) and of Pathology

Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

Thomas Pollard

Sterling Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Dean of the Graduate School of Arts and Sciences

Research Interests:Cytokinesis; cellular motility; role of actin filaments and myosin motors

Anna Marie Pyle

William Edward Gilbert Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry
Director, Division of Biological Sciences

Research Interests:Structure and function of catalytic RNA; RNA helicase mechanisms; Computational analysis of RNA structure

Yibing Qyang

Assistant Professor of Medicine (Cardiology) and of Pathology
Section of Cardiovascular Medicine

Research Interests:Heart; Stem cell; ES cell; iPS cell; Physiology; Tissue engineering; Small molecule; Patient; Disease; Cardiovascular

Lynne Regan

Professor of Molecular Biophysics and Biochemistry and of Chemistry

Research Interests:Mental retardation; protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); protein-based nanomaterials

Karin Reinisch

Associate Professor of Cell Biology

Valerie Reinke

Associate Professor of Genetics

Research Interests:Functional genomic analysis of global gene expression mechanisms; C. elegans germline development; germline stem cells

David Rimm

Professor of Pathology
Director of Pathology Tissue Services
Director of Translational Pathology

Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

Jesse Rinehart

Assistant Professor of Cellular and Molecular Physiology

Research Interests:Ion Transport; Kinase/Kinome Interactions in Physiological Systems; System-Wide & Targeted Phosphoproteomics; Protein Engineering

Matthew Rodeheffer

Assistant Professor of Comparative Medicine and of Molecular, Cellular, and Developmental Biology

Research Interests:Genomics; Stem Cells

John Rose

Professor of Pathology
Director, Molecular Virology Program

Research Interests:Virology; Vaccine and gene expression vectors based on rhabdoviruses; Membrane protein assembly, transport and targeting; Viral assembly

Joel Rosenbaum

Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Cilia, flagella, ciliopathies, organelle assembly, Intraflagellar Transport, molecular motors, kinesins and dyneins, sensory cila.

James Rothman

Fergus F. Wallace Professor of Cell Biology and Professor of Chemistry and Residential College Associate Fellow in Faculty of Arts and Sciences
Chairman, Department of Cell Biology
Director, Nanobiology Institute

Research Interests:Elucidating the underlying mechanisms of vesicular transport within cells and the secretion of hormones and neurotransmitters

David Schatz

Professor of Immunobiology
Professor of Molecular Biophysics and Biochemistry

Research Interests:Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; lymphocyte development; mechanisms of DNA repair; function of the RAG1 and RAG2 proteins; mechanisms of lymphomagenesis

Alanna Schepartz

Milton Harris Professor of Chemistry
Professor of Molecular, Cellular, & Developmental Biology

Research Interests:Organic chemistry; chemical biology; biosynthetic engineering; drug design; synthetic biology; Novel methods to inhibit HIV infection

Joseph Schlessinger

William H. Prusoff Professor of Pharmacology
Chair, Pharmacology
Director, Cancer Biology Institute

Research Interests:Growth factor receptors; Intracellular signaling pathways;protein kinases; phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; drug discovery

Christian Schlieker

Assistant Professor of Molecular Biophysics and Biochemistry

Research Interests:Protein folding; ubiquitin; Protein quality control and its relation to viral pathogenesis

Martin Schwartz

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology

Research Interests:Integrin signaling; mechanotransduction; atherosclerosis; vascular remodeling; heart disease; extracellular matrix; cell adhesion; cytoskeleton; cell-cell junctions; fluid shear stress

Michael Schwartz

Associate Professor of Neurobiology
Director, Medical Studies in Neurobiology
Associate Dean for Curriculum, YMS

Research Interests:Mammalian cerebral cortex

William Sessa

Alfred Gilman Professor of Pharmacology and Professor of Medicine (Cardiology)
Vice Chairman, Pharmacology
Director, Vascular Biology & Therapeutics Program

Research Interests:Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis

Gerald Shadel

Professor of Pathology and of Genetics
Director, Pathology Research

Research Interests:Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling

Gerald Shulman

George R. Cowgill Professor of Medicine (Endocrinology) and Professor of Cellular and Molecular Physiology
Investigator, Howard Hughes Medical Institute

Research Interests:Molecular mechanisms responsible for insulin resistance

Michael Simons

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology
Section Chief, Cardiovascular Medicine
Director, Yale Cardiovascular Research Center

Research Interests:Angiogenesis; Arteriogenesis; Lymphangiogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis

Frank Slack

Professor of Molecular, Cellular, and Developmental Biology

Research Interests:microRNA; aging; cancer biology; development; RNA; c. elegans

Clifford Slayman

Professor of Cellular and Molecular Physiology

Research Interests:Charge-dependent Transport; Proton Pumps; Potassium channels; Ribosomally Synthesized AntiMicrobial Peptides (RAMPs)

Mark Solomon

Professor of Molecular Biophysics and Biochemistry

Research Interests:Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex

Stefan Somlo

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Genetics
Chief, Section of Nephrology

Research Interests:Genetic kidney and liver disease; Cilia function in tissue homeostasis; Polycystin function

Matthew State

Donald J. Cohen Professor (Adjunct) in the Child Study Center and Professor of Genetics and of Psychiatry
Co-Director, Yale Program on Neurogenetics
Deputy Chairman for Research, Department of Psychiatry

Research Interests:Genetic mechanisms; neuropsychiatric disorders of childhood

David Stern

Professor of Pathology
Associate Director, Shared Resources, Yale Cancer Center
Leader, Signal Transduction Research Program, Yale Cancer Center

Research Interests:Cancer Biology: signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma

Stephen Strittmatter

Vincent Coates Professor of Neurology and Professor of Neurobiology
Director, Cellular Neuroscience, Neurodegeneration and Repair
Director, Adler Memory Clinic in Neurology

Research Interests:Axon Guidance; Axon Regeneration; Spinal Cord Injury; Molecular Biology; Stroke; Neurodegenerative Disease; Alzheimer's Disease; Fronto-Temporal Dementia

Scott Strobel

Henry Ford II Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Howard Hughes Medical Institute Professor
Henry Ford II Professor

Research Interests:Antibiotics; Nucleic Acid Bioorganic Chemistry; Ribosome; Ribozyme; RNA Catalysis; RNA-Protein Interaction; Translation; Riboswitches, Biofuels; Endophytes; Natural Product Discovery

Bing Su

Associate Professor of Immunobiology

Research Interests:MAP Kinase pathways; mTOR regulation; Receptor signaling; Cell growth control; Lymphocyte development and differentiation

Zhaoxia Sun

Associate Professor of Genetics

Research Interests:Zebrafish genetics; Cilium; Kidney development; Polycystic kidney disease (PKD); Ciliopathy

Patrick Sung

Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology

Research Interests:Repair of DNA double-strand breaks; repair by homologous recombination; repair by DNA end-joining

Richard Sutton

Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis

Research Interests:HIV replication and the development of small animal models of HIV; HIV vectors; HIV replication and gene transfer into non-dividing cells

Joann Sweasy

Professor of Therapeutic Radiology and of Genetics
Vice-Chair for Basic Research

Research Interests:Genome Stability; Mutagenesis; DNA Replication; DNA Repair; Carcinogenesis

Peter Takizawa

Assistant Professor of Cell Biology
Director, Medical Studies

Peter Tattersall

Professor of Laboratory Medicine and of Genetics

Research Interests:Biochemistry; Genetics; Parvoviruses; DNA replication; Gene therapy; Oncolytic virus; Vaccines; Vectors; Viral replication and vectors

Derek Toomre

Associate Professor of Cell Biology

Research Interests:Cell Biology; Exocytosis; Endocytosis; Membrane Traffic; Tethering; Microscopy; Live Cell Imaging; TIRFM; Single molecule

Benjamin Turk

Associate Professor of Pharmacology

Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering

Elisabetta Ullu

Professor of Medicine (Infectious Diseases) and of Cell Biology

Research Interests:eukaryotic cells

Flora Vaccarino

Harris Professor in the Child Study Center and Professor of Neurobiology and Residential College Associate Fellow in Faculty of Arts and Sciences

Research Interests:Neural stem cells; Cerebral cortex; Neuronal progenitors; Tyrosine kinase growth factors; Excitatory neurons; GABAergic neurons; Postmortem human brain; Induced pluripotent stem cells; Hypoxia

Agnès Vignery

Senior Research Scientist in Orthopaedics and Rehabilitation and in Cell Biology

Research Interests:Differentiation mechanism of osteoblasts; Fusion mechanism of macrophages

Tobias Walther

Associate Professor of Cell Biology

Research Interests:Organelle homeostasis; Plasma membrane organization; Lipid metabolism; Lipid Droplets; Eisosomes; Sphingolipid metabolism; Systematic genetics; RNAi screening; Mass-spectrometry based proteomics

Zenta Walther

Associate Professor of Pathology
Medical Director, YNHH Tumor Profiling Laboratory

Research Interests:epithelial polarity and proliferation control; intestinal epithelial homeostasis; intestinal barrier function; innate immune signalling

Scott Weatherbee

Assistant Professor of Genetics

Research Interests:Limb development; Developmental genetics; Organogenesis; Mouse genetics; Signaling pathways; Embryogenesis

Sherman Weissman

Sterling Professor of Genetics

Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics

Sandra Wolin

Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Vice Chair, Department of Cell Biology

Research Interests:RNA quality control; noncoding RNAs; RNA damage; autoimmune disease

Andrew Xiao

Assistant Professor of Genetics

Research Interests:Chromatin biology: histone variants, modifications and chromatin remodeling complexes; Cellular reprogramming (iPS) and stem cell biology; Mammalian neural crest cell; Mammalian DNA damage response

Tian Xu

Professor of Genetics
Vice Chairman of Genetics
Investigator, Howard Hughes Medical Institute

Research Interests:Genetic methodology; Cancer biology; Food and metabolism; Developmental mechanisms

Qin Yan

Assistant Professor of Pathology

Research Interests:Epigenetics; Transcription regulation; Cancer biology; Stem cell biology

Xiaoyong Yang

Assistant Professor of Comparative Medicine and of Cellular and Molecular Physiology

Research Interests:Nutrient Sensing; Circadian Rhythms; Metabolism; O-GlcNAc Modification; Nuclear Receptors; Diabetes; Cancer; Aging; Systems Biology

Jie Yao

Assistant Professor of Cell Biology

Research Interests:Transcription regulation; chromatin; nuclear periphery; nuclear compartmentalization; protein dynamics; cellular biophysics and imaging

David Zenisek

Associate Professor of Cellular and Molecular Physiology and of Ophthalmology and Visual Science

Research Interests:Physiology and cell biology of the presynaptic terminal; Retinal Bipolar Neuron; Synaptic Terminal; Synaptic Ribbons; Vesicle Transport; Exocytosis; Endocytosis

Yongli Zhang

Assistant Professor of Cell Biology

Research Interests:Single-molecule biophysics and biochemistry; optical tweezers; ATP-dependent chromatin remodeling; SNAREs; membrane fusion; dynamin; membrane fission

Hongyu Zhao

Ira V. Hiscock Professor of Public Health (Biostatistics) and Professor of Genetics and of Statistics

Research Interests:statistical genomics; computational biology; genetic epidemiology; genome wide association studies; complex diseases; risk prediction; high dimensional data; dimension reduction; network models; graphical models; bioinformatics; next generation sequencing analysis; cancer genomics; epigenetics; herbal medicine; microbiome; proteomics

Weimin Zhong

Associate Professor of Molecular, Cellular, and Developmental Biology

Research Interests:asymmetric cell division; differentiation; neurogenesis; progenitor cell; self-renewal; stem cell

Yong Zhu

Associate Professor of Epidemiology (Environmental Health)

Research Interests:Circadian genes; MicroRNAs; Shift-work; Breast Cancer; Lymphoma; Prostate Cancer