Molecular Cell Biology, Genetics, and Development Faculty
Murat Acar
Assistant Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Systems biology, synthetic biology, gene regulatory networks, noise in gene expression, aging, evolution of gene networks.
Herve Agaisse
Associate Professor of Microbial Pathogenesis
Research Interests:Host/pathogen interaction, microorganisms; infection; cell-to-cell spread; Listeria; Shigella; Chlamydia; Rickettsia; Vaccinia; Drosophila melanogaster; immune response; stem cells; JAK/STAT signaling; aging
Peter Aronson
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology
Research Interests:Urinary electrolyte excretion; cell membrane ion exchangers; proximal tubule
Allen Bale
Professor of Genetics
Director, DNA Diagnostic Lab
Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor
Susan Baserga
Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology
Research Interests:Ribosome biogenesis; rRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing
Anton Bennett
Associate Professor of Pharmacology and of Comparative Medicine
Co-Director, Program in Integrative Cell Signaling and Neurobiology of Metabolism
Director, BBS Minority Affairs
Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy
Joerg Bewersdorf
Assistant Professor of Cell Biology and of Biomedical Engineering
Research Interests:Super-resolution fluorescence microscopy
Jonathan Bogan
Associate Professor of Medicine (Endocrinology) and of Cell Biology
Research Interests:Protein trafficking; ubiquitin-like modification; cell structure; insulin signaling; type 2 diabetes; metabolic diseases
Titus Boggon
Associate Professor of Pharmacology
Research Interests:Structural biology of signal transduction
Alfred Bothwell
Professor of Immunobiology
Director of Graduate Studies
Research Interests:Human T cell recognition; inflammation and cancer; type 1 diabetes; function of PPARs
Emile Boulpaep
Professor of Cellular and Molecular Physiology
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology
Research Interests:Electrical properties of membrane proteins in plasma membranes and junctions of renal tubule cells
Douglas Brash
Senior Research Scientist in Therapeutic Radiology and Professor of Dermatology and of Genetics and Clinical Professor of Therapeutic Radiology
Research Interests:Ultraviolet Light; Skin Cancer
Ronald Breaker
Henry Ford II Professor of Molecular, Cellular, and Developmental Biology
Investigator, Howard Hughes Medical Institute
Research Interests:non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA's role in evolution
Thomas Brown
Professor of Psychology and of Cellular and Molecular Physiology
Research Interests:Neurobiological mechanism of learning and memory.
Gary Brudvig
Eugene Higgins Professor of Chemistry and Professor of Molecular Biophysics and Biochemistry
Research Interests:photosystem II; EPR spectroscopy; metalloproteins; artificial photosynthesis
Martina Brueckner
Associate Professor of Pediatrics (Cardiology) and of Genetics
Research Interests:Development of left-right asymmetry; Heterotaxy syndrome; Kartagener syndrome; Situs inversus
Christopher Burd
Associate Professor of Cell Biology
David Calderwood
Associate Professor of Pharmacology and of Cell Biology
Research Interests:Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology
Cecilia Canessa
Professor of Cellular and Molecular Physiology and of Medicine (Nephrology)
Research Interests:Renal Function; Epithelial Sodium Channels
Michael Caplan
C. N. H. Long Professor of Cellular and Molecular Physiology and Professor of Cell Biology
Chair, Cellular and Molecular Physiology
Research Interests:Ion pumps in polarized epithelia; Sorting and function
John Carlson
Eugene Higgins Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Drosophila, olfaction, taste, Anopheles, mosquito
Topher Carroll
Assistant Professor of Cell Biology
Research Interests:Epigenetics; Chromosomes; Chromatin; Gene expression; Nuclear Organization; Nuclear Membrane;
Sreeganga Chandra
Assistant Professor of Neurology and of Molecular, Cellular, and Developmental Biology
Research Interests:Presynaptic Biology; Synapse Maintenance; Parkinson's Disease; Neurodegeneration
Kei-Hoi Cheung
Associate Professor of Anesthesiology (Medical Informatics) and of Genetics
Research Interests:Genetic database and tool interpolation
Tian Chi
Associate Professor of Immunobiology
Research Interests:Epigenetic memory; transgenerational inheritance; chromatin biology
Judy Cho
Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and Professor of Genetics and of Pediatrics (Gastroenterology)
Director, Inflammatory Bowel Disease Center
Research Interests:Inflammatory Bowel Disease (IBD); identifying genetic variation that affects susceptibility to and expression of Inflammatory Bowel Disease (IBD)
Damon Clark
Assistant Professor of Molecular, Cellular, and Developmental Biology and Residential College Associate Fellow in Faculty of Arts and Sciences
Nicole Clay
Assistant Professor of Molecular, Cellular, and Developmental Biology
Daniel Colon-Ramos
Assistant Professor of Cell Biology
Research Interests:Neural connectivity; Brain; Nematode C. elegans
Lynn Cooley
C. N. H. Long Professor of Genetics and Professor of Cell Biology and of Molecular, Cellular, and Developmental Biology
Director, Combined Program in the Biological & Biomedical Sciences
Research Interests:Molecular Genetics of Drosophila Oogenesis; Actin Cytoskeleton Regulation; Drosophila; Oogenesis; Ring Canal; Ovarian Muscle Function
Chris Cotsapas
Assistant Professor of Neurology and of Genetics
Research Interests:We use genetics, computational biology and cell-based approaches to discover and understand the mechanisms that give rise to disease. We are particularly interested in disorders of the immune system and brain.
Peter Cresswell
Eugene Higgins Professor of Immunobiology and Professor of Cell Biology and of Dermatology
Research Interests:Molecular mechanisms of antigen processing; assembly and intracellular transport of CD1 molecules, class I and class II MHC molecules; effector functions and mechanisms of action of interferon-induced proteins; viral immunity
Craig Crews
Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry and of Pharmacology
Executive Director, Yale Molecular Discovery Center
Research Interests:Limb regeneration; wound epidermis; blastema; natural product mode of action studies; angiogenesis; Wnt signaling; protein turnover; protein kinase regulation
Pietro De Camilli
Eugene Higgins Professor of Cell Biology and Professor of Neurobiology
Director, Yale Program in Cellular Neuroscience and Neurodegeneration and Repair
Investigator, Howard Hughes Medical Institute
Research Interests:Synapses; exocytosis; endocytosis; membranes; clathrin; dynamin; phosphoinositides; Lowe syndrome; BAR proteins; neurodegeneration
Enrique De La Cruz
Professor of Molecular Biophysics and Biochemistry
Research Interests:Cytoskeleton; RNA helicases; Kinetics; Thermodynamics; Polymer Mechanics; Processivity
Stephen Dellaporta
Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Functional genomics; plant molecular genetics; marine genomics; biofuels
Xing Wang Deng
Daniel C. Eaton Professor of Molecular, Cellular, and Developmental Biology
Daniel C. Eaton Professor of Plant Biology at Yale
Director of Peking-Yale Center for Plant Molecular Genetics & Agrobiotechnology
Research Interests:Plant Biology, Genome and Epigenome, Development mechanism, Hybrid Vigor, Agribiotechnology Light Regulation
Michael DiGiovanna
Associate Professor of Medicine (Medical Oncology) and of Pharmacology
Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; estrogen receptor, signal transduction
Ralph DiLeone
Associate Professor of Psychiatry and of Neurobiology
Research Interests:Addictions; Animal Behavior; Ethology; Animal Nutrition; Diseases and Disorders; Drug Abuse; Eating Disorders; Etiology; Evolution; Genetic Manipulation; Natural History; Obesity; Psychiatry
Daniel DiMaio
Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Scientific Director, Yale Cancer Center
Deputy Director, Yale Cancer Center
Research Interests:Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence ; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus
Thierry Emonet
Associate Professor of Molecular, Cellular, and Developmental Biology and of Physics
Research Interests:Computational Biology chemotaxis, olfaction, immunology
Shawn Ferguson
Assistant Professor of Cell Biology
Research Interests:lysosomes; membrane traffic; energy homeostasis; nutrient homeostasis; transcription factor; signaling; neurodegeneration; neuronal ceroid lipofuscinosis; genetics
Biff Forbush
Professor of Cellular and Molecular Physiology
Research Interests:Membrane Proteins; Epithelial Transport; Ion Transport; Na-K-Cl Cotransporter; Nerve Cells; Muscle Cells
Paul Forscher
Professor of Molecular, Cellular, and Developmental Biology
Research Interests:cytoskeleton; actin filament; microtubule; protein dynamics; axon growth; axon guidance; axon regeneration; mechanotransduction; calcium; Rho GTPase
Jorge Galan
Lucille P. Markey Professor of Microbial Pathogenesis and Professor of Cell Biology
Chair, Department of Microbial Pathogenesis
Research Interests:Microbial Pathogenesis; host/pathogen interaction
Patrick Gallagher
Professor of Pediatrics (Neonatology), of Genetics and of Pathology
Director, Yale Center for Blood Disorders
Director, Expression and Genomics Core, Yale Center of Excellence in Molecular Hematology
Research Interests:Neonatal hematology; Erythropoiesis; Inherited abnormalities of the erythrocyte including metabolic, membrane, and hemoglobin disorders; Sickle cell disease; Hereditary spherocytosis; Elliptocytosis; Pyropoikilocytosis; Stomatocytosis
Martin Garcia-Castro
Associate Professor of Molecular, Cellular, and Developmental Biology
Joel Gelernter
Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neurobiology
Director, Division of Human Genetics (Psychiatry)
Research Interests:Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Gene mapping
Mark Gerstein
Albert L. Williams Professor of Biomedical Informatics
Co-Director, Yale Computational biology and Bioinformatics Program
Research Interests:Biochemistry; Bioinformatics; Biophysics; Computational Biology; DNA; Genomics; Molecular Simulation; Proteins; Sequence Alignment; Structural Biology
Antonio Giraldez
Associate Professor of Genetics
Member of the Yale Cancer Center
Member of the Stem Cell Center
Director of Graduate Studies
Research Interests:Non-coding RNAs, Post-transcriptional regulation; microRNAs; Developmental Biology; Gene regulatory networks; Systems Biology; Zebrafish
Peter Glazer, MD, PhD
Robert E. Hunter Professor of Therapeutic Radiology and Professor of Genetics
Chair, Department of Therapeutic Radiology
Research Interests:Gene targeting and gene therapy; Genetic instability in cancer; Mutagenesis; DNA repair; Radiation resistance; Cellular responses to radiation
Andrew Goodman
Assistant Professor of Microbial Pathogenesis
Research Interests:Microbiota; Microbiome; Genomics; Gnotobiotic; Germfree; Symbiosis; Gut; Flora; Bacteria; Pathogen
Fred Gorelick
Professor of Medicine (Digestive Diseases) and of Cell Biology
Associate Director, Yale M.D., Ph.D. Program
Research Interests:Exocrine pancreas; pancreatitis; intracellular proteolysis; vacuolar ATPase; AMPK; protein kinase C
Valentina Greco
Assistant Professor of Genetics and of Dermatology
Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; cancer
Eduardo Groisman
Professor of Microbial Pathogenesis and Residential College Associate Fellow in Faculty of Arts and Sciences
HHMI Investigator
Research Interests:bacterial genetics; signal transduction; infectious diseases; gene regulation; bacteria-host interactions; gut commensal bacteria
Jeffrey Gruen
Professor of Pediatrics (Neonatology) and of Genetics
Research Interests:Complex inherited traits including bladder exstrophy; Genetic susceptibility to newborn disorders; Genetics of reading disability (dyslexia)
Murat Gunel
Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neurobiology
Co-Director, Yale Program on Neurogenetics
Director, Neurovascular Surgery
Research Interests:Molecular genetics and biology of brain aneurysms and cavernous malformations; molecular genetics of brain development
Marc Hammarlund
Assistant Professor of Genetics
Research Interests:Axon regeneration and degeneration; Neuronal plasticity; Femtosecond laser surgery; C. elegans neurobiology
Jo Handelsman
Professor of Molecular, Cellular, and Developmental Biology
Frederick Phineas Rose Professor
Howard Hughes Medical Institute Professor
Carl Hashimoto
Professor of Cell Biology
Research Interests:Proteolysis; serpins; intercellular signaling; morphogenesis; disease modeling; Drosophila molecular genetics
Shilpa Hattangadi
Assistant Professor of Pediatrics (Hematology / Oncology) and of Pathology
Assistant Professor, Pathology
Research Interests:Terminal erythroid development, hematopoiesis; bone marrow failure; red cell aplasia; chromatin condensation; nuclear protein export; proteomics; genomics; transcriptional regulation; histone modification; post-transcriptional modification of hematopoietic regulators
Michael Higley
Assistant Professor of Neurobiology
Primary Member, Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR)
Member, Kavli Institute fir Neuroscience
Research Interests:Synaptic integration; GABAergic interneurons; Inhibition; 2-photon; Electrophysiology
Mark Hochstrasser
Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin
Scott Holley
Associate Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Somitogenesis, Body Elongation, Morphogenesis, Developmental Gene Networks, Embryo Biomechanics
Valerie Horsley
Assistant Professor of Molecular, Cellular, and Developmental Biology and of Dermatology
Arthur Horwich
Sterling Professor of Genetics and Professor of Pediatrics
and Investigator HHMI
Research Interests:Chaperones in protein folding; ALS (Lou Gehrig's Disease)
Michael Hurwitz
Assistant Professor of Medicine (Medical Oncology)
Research Interests:Cell migration; Kinase signaling; Phosphorylation; Cytoskeleton; Engulfment; Apoptosis; C. elegans; Cancer biology
Vivian Irish
Professor of Molecular, Cellular, and Developmental Biology and of Ecology and Evolutionary Biology
Research Interests:developmental genetics; Arabidopsis; evolution of development
Farren Isaacs
Assistant Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Synthetic Biology; Systems Biology; Genomics; Biotechnology
Natalia Ivanova
Assistant Professor of Genetics
Research Interests:Embryonic and somatic stem cells; Vertebrate development; Functional genomics; Systems biology
Akiko Iwasaki
Professor of Immunobiology and of Molecular, Cellular, and Developmental Biology
Professor of Molecular Cellular and Developmental Biology
Howard Hughes Medical Investigator
Research Interests:Innate immunity; Autophagy; Inflammasomes; sexually transmitted infections; Herpes simplex virus; human papillomavirus;respiratory virus infections; Influenza infection; T cell immunity; Commensal bacteria
Christine Jacobs-Wagner
Professor of Molecular, Cellular, and Developmental Biology and of Microbial Pathogenesis
HHMI Investigator
Research Interests:Cell division; chromosome segregation; cell cycle coordination; cell morphogenesis, cytokeleton, cell polarity
Samuel Katz
Assistant Professor of Pathology
Paula Kavathas
Professor of Laboratory Medicine, of Genetics, of Immunobiology and of Molecular, Cellular, and Developmental Biology
Associate Chair for Research
Director, Science Education Outreach Program
Research Interests:Gene Regulation; Immunology; Molecular Cellular Entities; Receptors; Structure or Function (Health or Safety or Medical); Transgenic Animals
Barbara Kazmierczak
Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis
Associate Director for Basic Research, MD-PhD Program, Yale University
Research Interests:Pseudomonas aeruginosa; Staphylococcus aureus; innate immunity; host-pathogen interactions; mucosal immunity
Haig Keshishian
Professor of Molecular, Cellular, and Developmental Biology
Mustafa Khokha
Associate Professor of Pediatrics (Critical Care) and of Genetics
Research Interests:Establishment of vertebrate body plan; Embryonic patterning and gene regulatory networks; Xenopus (frog) genetics
Kenneth Kidd
Professor of Genetics, of Ecology and Evolutionary Biology and of Psychiatry
Research Interests:Complex Human Disorders; Neuropsychiatric Disorders; Human Population ; Genetics; Human Evolution
In-Jung Kim
Assistant Professor of Ophthalmology and Visual Science and of Neurobiology
Research Interests:Neuroscience; Development; Visual System; Neural Circuits; Transgenic approaches; Direction Selectivity
Tae Hoon Kim
Assistant Professor of Genetics
Member, Yale Cancer Center
Member, Yale Stem Cell Center
Research Interests:Transcriptional Regulatory Elements and Chromatin Structure; Expression of the Cancer Genome; Epigenomics
Megan King
Assistant Professor of Cell Biology
Research Interests:microtubules; nucleus; nuclear envelope; DNA repair; cellular mechanics; telomere biology
Michael Koelle
Associate Professor of Molecular Biophysics and Biochemistry
Research Interests:C. Elegans; G Protein; Neurotransmission; RGS Protein; Serotonin; Molecular Genetics; Neurobiology; Neurotransmitters; Proteins and Macromolecules; Receptors
Anthony Koleske
Professor of Molecular Biophysics and Biochemistry and of Neurobiology
Research Interests:Neuronal morphogenesis and degeneration; stress; schizophrenia; cell migration; cancer; metastasis; adhesion receptors
William Konigsberg
Professor of Molecular Biophysics and Biochemistry
Research Interests:Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
Diane Krause
Professor of Laboratory Medicine, of Cell Biology and of Pathology
Assoc. Director, Yale Stem Cell Center
Assoc. Director, Transfusion Medicine Service
Director, Frisbee Laboratory for Hematopoietic Graft Engineering
Research Interests:Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia
Gary Kupfer
Professor of Pediatrics (Hematology / Oncology) and of Pathology
Clinical Program Leader, Pediatric Hematology & Oncology Program, Smilow Cancer Hospital
Section Chief, Pediatric Hematology/Oncology
Clinical Research Program Leader, Pediatric Hematology & Oncology Program, Yale Cancer Center
Research Interests:Genomic instability; Development of cancer; Genetic syndrome Fanconi anemia (FA); Viral protein enhancement of cancer therapeutics
Themis Kyriakides
Associate Professor of Pathology and of Biomedical Engineering
Research Interests:Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Gene delivery; Biomaterials
Peining Li
Associate Professor of Genetics
Research Interests:Cytogenetic and genomic analysis; Dissection of genetic mechanisms for growth regulation, mental development, and cancer progression
Richard Lifton
Sterling Professor of Genetics and Professor of Medicine (Nephrology)
Chair, Department of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Molecular genetics of common human diseases
Janghoo Lim
Assistant Professor of Genetics
Research Interests:Mechanisms of neural development, neurological disorders, and neurodegenerative diseases
Chenxiang Lin
Assistant Professor of Cell Biology
Research Interests:Engineering DNA-nanostructure-based molecular tools for biological study
Haifan Lin
Professor of Cell Biology and of Genetics
Director, Yale Stem Cell Center
Research Interests:RNA-mediated epigenetic programming and post-transcriptional regulation of stem cells
Jun Lu
Assistant Professor of Genetics
Research Interests:Non-coding RNAs in blood stem cell differentiation and malignancies; MicroRNA-mediated control of embryonic stem cell fates; MicroRNA mechanisms
Patrick Lusk
Assistant Professor of Cell Biology
Research Interests:nuclear pore complex; nuclear periphery; membrane proteins; chromatin structure
Joseph Madri
Professor of Pathology
Director of Education
Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell-Endothelial cell interactions
Arya Mani
Associate Professor of Medicine (Cardiology) and of Genetics
Director, Cardiovascular Genetics Program
Research Interests:Identification of cardiovascular disorders that have strong familial pattern
Malaiyalam Mariappan
Assistant Professor of Cell Biology
Research Interests:Membrane protein homeostasis; Membrane protein targeting and insertion; Membrane protein assembly; Misfolded membrane protein degradation; Biochemical reconstitution
Ruslan Medzhitov
David W. Wallace Professor of Immunobiology
Investigator, Howard Hughes Medical Institute
Research Interests:Inflammation; Allergy; Immunology; Innate Immunity; Pathophysiology
Perry Miller
Professor of Anesthesiology (Medical Informatics)
Research Interests:Biomedical informatics; Clinical informatics; Bioinformatics; Neuroinformatics
Kathryn Miller-Jensen
Assistant Professor of Biomedical Engineering and of Molecular, Cellular, and Developmental Biology
Mark Mooseker
Ross Granville Harrison Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology
and Pathlogy
Research Interests:The cytoskeleton. Epithelial cell biology. molecular motors
Jon Morrow
Raymond Yesner Professor of Pathology
Chair, Department of Pathology
Chief of Pathology at YNHH
Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology
Walther Mothes
Associate Professor of Microbial Pathogenesis
Research Interests:cell biology; retroviral replication; retroviruses; immune; viral biology; genetic; biochemical; cell imaging; Viral entry and exit; Retroviruses including HIV
Michael Nathanson
Professor of Medicine (Digestive Diseases) and of Cell Biology
Section Chief, Digestive Diseases
Director, Yale Liver Center
Director, Center for Cell and Molecular Imaging
Research Interests:Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus
Timothy Nelson
Professor of Molecular, Cellular, and Developmental Biology
Director, Marsh Botanical Garden
Research Interests:Arabidopsis; Zea mays; vascular patterning
Don Nguyen
Assistant Professor of Pathology
Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment
Michael Nitabach
Associate Professor of Cellular and Molecular Physiology and of Genetics
Research Interests:Neurophysiology; Molecular genetics; Systems Physiology; Animal Behavior
James Noonan
Assistant Professor of Genetics
Member, Kavli Institute for Neuroscience
Member, Yale Cancer Center
Research Interests:Human Evolution; Evolutionary Dynamics of Gene Regulation; Synthetic Biology; Applications of Ultra-High Throughput Sequencing Technologies; Comparative and Functional Genomics in Vertebrates
In-Hyun Park
Assistant Professor of Genetics
Yale Stem Cell Center
Research Interests:Reprogramming; iPS cells; neurodevelopment; epigenetics
Katerina Politi
Assistant Professor of Medicine (Medical Oncology) and of Pathology
Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy
Thomas Pollard
Sterling Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Dean of the Graduate School of Arts and Sciences
Research Interests:Cytokinesis; cellular motility; role of actin filaments and myosin motors
Anna Marie Pyle
William Edward Gilbert Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry
Director, Division of Biological Sciences
Research Interests:Structure and function of catalytic RNA; RNA helicase mechanisms; Computational analysis of RNA structure
Yibing Qyang
Assistant Professor of Medicine (Cardiology) and of Pathology
Section of Cardiovascular Medicine
Research Interests:Heart; Stem cell; ES cell; iPS cell; Physiology; Tissue engineering; Small molecule; Patient; Disease; Cardiovascular
Lynne Regan
Professor of Molecular Biophysics and Biochemistry and of Chemistry
Research Interests:Mental retardation; protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); protein-based nanomaterials
Karin Reinisch
Associate Professor of Cell Biology
Valerie Reinke
Associate Professor of Genetics
Research Interests:Functional genomic analysis of global gene expression mechanisms; C. elegans germline development; germline stem cells
David Rimm
Professor of Pathology
Director of Pathology Tissue Services
Director of Translational Pathology
Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology
Jesse Rinehart
Assistant Professor of Cellular and Molecular Physiology
Research Interests:Ion Transport; Kinase/Kinome Interactions in Physiological Systems; System-Wide & Targeted Phosphoproteomics; Protein Engineering
Matthew Rodeheffer
Assistant Professor of Comparative Medicine and of Molecular, Cellular, and Developmental Biology
Research Interests:Genomics; Stem Cells
John Rose
Professor of Pathology
Director, Molecular Virology Program
Research Interests:Virology; Vaccine and gene expression vectors based on rhabdoviruses; Membrane protein assembly, transport and targeting; Viral assembly
Joel Rosenbaum
Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Cilia, flagella, ciliopathies, organelle assembly, Intraflagellar Transport, molecular motors, kinesins and dyneins, sensory cila.
James Rothman
Fergus F. Wallace Professor of Cell Biology and Professor of Chemistry and Residential College Associate Fellow in Faculty of Arts and Sciences
Chairman, Department of Cell Biology
Director, Nanobiology Institute
Research Interests:Elucidating the underlying mechanisms of vesicular transport within cells and the secretion of hormones and neurotransmitters
David Schatz
Professor of Immunobiology
Professor of Molecular Biophysics and Biochemistry
Research Interests:Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; lymphocyte development; mechanisms of DNA repair; function of the RAG1 and RAG2 proteins; mechanisms of lymphomagenesis
Alanna Schepartz
Milton Harris Professor of Chemistry
Professor of Molecular, Cellular, & Developmental Biology
Research Interests:Organic chemistry; chemical biology; biosynthetic engineering; drug design; synthetic biology; Novel methods to inhibit HIV infection
Joseph Schlessinger
William H. Prusoff Professor of Pharmacology
Chair, Pharmacology
Director, Cancer Biology Institute
Research Interests:Growth factor receptors; Intracellular signaling pathways;protein kinases; phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; drug discovery
Christian Schlieker
Assistant Professor of Molecular Biophysics and Biochemistry
Research Interests:Protein folding; ubiquitin; Protein quality control and its relation to viral pathogenesis
Martin Schwartz
Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology
Research Interests:Integrin signaling; mechanotransduction; atherosclerosis; vascular remodeling; heart disease; extracellular matrix; cell adhesion; cytoskeleton; cell-cell junctions; fluid shear stress
Michael Schwartz
Associate Professor of Neurobiology
Director, Medical Studies in Neurobiology
Associate Dean for Curriculum, YMS
Research Interests:Mammalian cerebral cortex
William Sessa
Alfred Gilman Professor of Pharmacology and Professor of Medicine (Cardiology)
Vice Chairman, Pharmacology
Director, Vascular Biology & Therapeutics Program
Research Interests:Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis
Gerald Shadel
Professor of Pathology and of Genetics
Director, Pathology Research
Research Interests:Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling
Gerald Shulman
George R. Cowgill Professor of Medicine (Endocrinology) and Professor of Cellular and Molecular Physiology
Investigator, Howard Hughes Medical Institute
Research Interests:Molecular mechanisms responsible for insulin resistance
Michael Simons
Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology
Section Chief, Cardiovascular Medicine
Director, Yale Cardiovascular Research Center
Research Interests:Angiogenesis; Arteriogenesis; Lymphangiogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis
Frank Slack
Professor of Molecular, Cellular, and Developmental Biology
Research Interests:microRNA; aging; cancer biology; development; RNA; c. elegans
Clifford Slayman
Professor of Cellular and Molecular Physiology
Research Interests:Charge-dependent Transport; Proton Pumps; Potassium channels; Ribosomally Synthesized AntiMicrobial Peptides (RAMPs)
Mark Solomon
Professor of Molecular Biophysics and Biochemistry
Research Interests:Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex
Stefan Somlo
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Genetics
Chief, Section of Nephrology
Research Interests:Genetic kidney and liver disease; Cilia function in tissue homeostasis; Polycystin function
Matthew State
Donald J. Cohen Professor (Adjunct) in the Child Study Center and Professor of Genetics and of Psychiatry
Co-Director, Yale Program on Neurogenetics
Deputy Chairman for Research, Department of Psychiatry
Research Interests:Genetic mechanisms; neuropsychiatric disorders of childhood
David Stern
Professor of Pathology
Associate Director, Shared Resources, Yale Cancer Center
Leader, Signal Transduction Research Program, Yale Cancer Center
Research Interests:Cancer Biology: signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma
Stephen Strittmatter
Vincent Coates Professor of Neurology and Professor of Neurobiology
Director, Cellular Neuroscience, Neurodegeneration and Repair
Director, Adler Memory Clinic in Neurology
Research Interests:Axon Guidance; Axon Regeneration; Spinal Cord Injury; Molecular Biology; Stroke; Neurodegenerative Disease; Alzheimer's Disease; Fronto-Temporal Dementia
Scott Strobel
Henry Ford II Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Howard Hughes Medical Institute Professor
Henry Ford II Professor
Research Interests:Antibiotics; Nucleic Acid Bioorganic Chemistry; Ribosome; Ribozyme; RNA Catalysis; RNA-Protein Interaction; Translation; Riboswitches, Biofuels; Endophytes; Natural Product Discovery
Bing Su
Associate Professor of Immunobiology
Research Interests:MAP Kinase pathways; mTOR regulation; Receptor signaling; Cell growth control; Lymphocyte development and differentiation
Zhaoxia Sun
Associate Professor of Genetics
Research Interests:Zebrafish genetics; Cilium; Kidney development; Polycystic kidney disease (PKD); Ciliopathy
Patrick Sung
Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Research Interests:Repair of DNA double-strand breaks; repair by homologous recombination; repair by DNA end-joining
Richard Sutton
Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis
Research Interests:HIV replication and the development of small animal models of HIV; HIV vectors; HIV replication and gene transfer into non-dividing cells
Joann Sweasy
Professor of Therapeutic Radiology and of Genetics
Vice-Chair for Basic Research
Research Interests:Genome Stability; Mutagenesis; DNA Replication; DNA Repair; Carcinogenesis
Peter Takizawa
Assistant Professor of Cell Biology
Director, Medical Studies
Peter Tattersall
Professor of Laboratory Medicine and of Genetics
Research Interests:Biochemistry; Genetics; Parvoviruses; DNA replication; Gene therapy; Oncolytic virus; Vaccines; Vectors; Viral replication and vectors
Derek Toomre
Associate Professor of Cell Biology
Research Interests:Cell Biology; Exocytosis; Endocytosis; Membrane Traffic; Tethering; Microscopy; Live Cell Imaging; TIRFM; Single molecule
Benjamin Turk
Associate Professor of Pharmacology
Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering
Elisabetta Ullu
Professor of Medicine (Infectious Diseases) and of Cell Biology
Research Interests:eukaryotic cells
Flora Vaccarino
Harris Professor in the Child Study Center and Professor of Neurobiology and Residential College Associate Fellow in Faculty of Arts and Sciences
Research Interests:Neural stem cells; Cerebral cortex; Neuronal progenitors; Tyrosine kinase growth factors; Excitatory neurons; GABAergic neurons; Postmortem human brain; Induced pluripotent stem cells; Hypoxia
Agnès Vignery
Senior Research Scientist in Orthopaedics and Rehabilitation and in Cell Biology
Research Interests:Differentiation mechanism of osteoblasts; Fusion mechanism of macrophages
Tobias Walther
Associate Professor of Cell Biology
Research Interests:Organelle homeostasis; Plasma membrane organization; Lipid metabolism; Lipid Droplets; Eisosomes; Sphingolipid metabolism; Systematic genetics; RNAi screening; Mass-spectrometry based proteomics
Zenta Walther
Associate Professor of Pathology
Medical Director, YNHH Tumor Profiling Laboratory
Research Interests:epithelial polarity and proliferation control; intestinal epithelial homeostasis; intestinal barrier function; innate immune signalling
Scott Weatherbee
Assistant Professor of Genetics
Research Interests:Limb development; Developmental genetics; Organogenesis; Mouse genetics; Signaling pathways; Embryogenesis
Sherman Weissman
Sterling Professor of Genetics
Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics
Sandra Wolin
Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Vice Chair, Department of Cell Biology
Research Interests:RNA quality control; noncoding RNAs; RNA damage; autoimmune disease
Andrew Xiao
Assistant Professor of Genetics
Research Interests:Chromatin biology: histone variants, modifications and chromatin remodeling complexes; Cellular reprogramming (iPS) and stem cell biology; Mammalian neural crest cell; Mammalian DNA damage response
Tian Xu
Professor of Genetics
Vice Chairman of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Genetic methodology; Cancer biology; Food and metabolism; Developmental mechanisms
Qin Yan
Assistant Professor of Pathology
Research Interests:Epigenetics; Transcription regulation; Cancer biology; Stem cell biology
Xiaoyong Yang
Assistant Professor of Comparative Medicine and of Cellular and Molecular Physiology
Research Interests:Nutrient Sensing; Circadian Rhythms; Metabolism; O-GlcNAc Modification; Nuclear Receptors; Diabetes; Cancer; Aging; Systems Biology
Jie Yao
Assistant Professor of Cell Biology
Research Interests:Transcription regulation; chromatin; nuclear periphery; nuclear compartmentalization; protein dynamics; cellular biophysics and imaging
David Zenisek
Associate Professor of Cellular and Molecular Physiology and of Ophthalmology and Visual Science
Research Interests:Physiology and cell biology of the presynaptic terminal; Retinal Bipolar Neuron; Synaptic Terminal; Synaptic Ribbons; Vesicle Transport; Exocytosis; Endocytosis
Yongli Zhang
Assistant Professor of Cell Biology
Research Interests:Single-molecule biophysics and biochemistry; optical tweezers; ATP-dependent chromatin remodeling; SNAREs; membrane fusion; dynamin; membrane fission
Hongyu Zhao
Ira V. Hiscock Professor of Public Health (Biostatistics) and Professor of Genetics and of Statistics
Research Interests:statistical genomics; computational biology; genetic epidemiology; genome wide association studies; complex diseases; risk prediction; high dimensional data; dimension reduction; network models; graphical models; bioinformatics; next generation sequencing analysis; cancer genomics; epigenetics; herbal medicine; microbiome; proteomics
Weimin Zhong
Associate Professor of Molecular, Cellular, and Developmental Biology
Research Interests:asymmetric cell division; differentiation; neurogenesis; progenitor cell; self-renewal; stem cell
Yong Zhu
Associate Professor of Epidemiology (Environmental Health)
Research Interests:Circadian genes; MicroRNAs; Shift-work; Breast Cancer; Lymphoma; Prostate Cancer
