Marcus W. Bosenberg MD, PhD

Associate Professor of Dermatology and of Pathology

Research Interests

Melanocytic neoplasms; Soft tissue tumors; Cutaneous lymphoma; Genodermatoses


Research Summary

Directs a National Cancer Institute funded melanoma research laboratory with interests in several aspects of melanoma biology including the cell biology and genetics of metastasis, prognostic and diagnostic markers and development of new therapeutic agents.

Extensive Research Description

Directs a National Cancer Institute funded melanoma research laboratory with interests in several aspects of melanoma biology including the cell biology and genetics of metastasis, prognostic and diagnostic markers and development of new therapeutic agents.


Selected Publications

  • Held MA, Langdon CG, Platt JT, Graham-Steed T, Liu Z, Chakraborty A, Bacchiocchi A, Koo A, Haskins JW, Bosenberg MW*, David F. Stern DF*. Genotype-selective combination therapies for melanoma identified by high-throughput drug screening. Cancer Discovery. 2013, 3:52-67
  • Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet. 2012, 44:1006-14.
  • Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. ß-catenin signaling controls metastasis in BRAF-activated Pten-deficient melanomas. Cancer Cell. 2011, 20:741-54.
  • Held MA, Curley DP, Dankort D, McMahon M, Bosenberg MW. Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010, 70:388-97.
  • Dankort D*, Curley DP*, Cartilage RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M*, Bosenberg M*. BrafV600E cooperates with Pten silencing to induce metastatic melanoma. Nat Genet. 2009, 41:544-52.

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