We are interested in links between in transcription and splicing, as well as the role of cellular subcompartments in RNA biogenesis. We use imaging, techniques that capture RNA-protein interactions, and next generation sequencing as major tools. We study these phenomena in yeast (fission and budding), zebrafish and mammalian tissue culture cells.
- M. Brugiolo, L. Herzel and K.M. Neugebauer. 2013. Counting on Co-transcriptional Splicing. F1000Prime Reports 5:9-15.
- Müller-McNicoll, M. and K.M. Neugebauer. 2013. How cells get the message: dynamic assembly and function of mRNA-protein complexes. Nature Reviews Genetics 14:275-87.
- Bieberstein, N., F. Carrillo Oesterreich, K. Straube and K.M. Neugebauer. 2012. First exon length controls active chromatin signatures and transcription. Cell Reports 2:62-68.
- Änkö, M-L., M. Müller-McNicoll, H. Brandl, T. Curk, C. Gorup, I. Henry, J. Ule and K.M. Neugebauer. 2012. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Genome Biology 13: R17.
- Carrillo Oesterreich, F., S. Preibisch, and K.M. Neugebauer. 2010. Global analysis of nascent RNA reveals transcriptional pausing in terminal exons. Molecular Cell 40: 571-581.
- Strzelecka, M, S. Trowitzsch, G. Weber, R. Lührmann, A.C. Oates and K.M. Neugebauer. 2010. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17: 403–409.