John D MacMicking, PhD

Associate Professor of Microbial Pathogenesis; Investigator, Howard Hughes Medical Institute

Departments & Organizations

Microbial Pathogenesis


Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology: Computational Immunology; Infectious Disease and Host-Pathogen Interaction; Mounting an Immune Response; Regulating the Immune Response; Structural Analysis of Immune System Receptors and Effectors | Microbiology: Bacteria; Immunology & Host Response

Office of Cooperative Research


Dr. MacMicking began research as an undergraduate B.Sc Honours Fellow (1st Class) within the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the the John Curtin School of Medical Research, Australian National University in Canberra.

He then pursued Ph. D studies with Carl Nathan in the combined Immunology program at Sloan-Kettering Institute-Cornell University Medical College in New York City before post-doctoral work as an HHMI Life Science Research Foundation Fellow and Adjunct Assistant Professor at the Rockefeller University with John McKinney. Here he identified and began characterizing members of an IFN-inducible GTPase superfamily important for cell-autonomous immunity to infection. Since joining Yale in 2004 his work in this area has been recognized through several awards, being named a 2004 Edward Mallinckrodt Jr Foundation Fellow, 2005 Searle Scholar, 2006 Cancer Research Institute Investigator, 2008 Burroughs-Wellcome Fund Investigator in the Pathogenesis of Infectious Disease, 2010 CCFA Senior Research Awardee, 2014 AAF Scholar and 2014 Kenneth Rainin Foundation Innovator.

Dr. MacMicking was promoted to Associate Professor in 2010 and received Tenure in 2014. He was selected as a Howard Hughes Medical Institute (HHMI) Investigator in 2015 and began a joint appointment in the Department of Immunobiology in 2016.

Education & Training

PhD Cornell University (1997)
BS Australian National Univ (1990)
Assistant Professor (Adjunct) The Rockefeller University
Research Associate The Rockefeller University
HHMI LSRF Fellow The Rockefeller University
Revson Biomedical Fellow The Rockefeller University

Honors & Recognition

  • Howard Hughes Medical Institute (HHMI) Investigator (2015)

  • Innovator Award, Kenneth Rainin Foundation (2014)

  • American Asthma Foundation (AAF) Scholar (2014)

  • Crohn’s and Colitis Foundation of America (CCFA) Senior Investigator Award (2010)

  • Burroughs Wellcome Fund (BWF) Investigator in the Pathogenesis of Infectious Disease Award (2008)

  • Cancer Research Institute (CRI) Investigator Award (2006)

  • Searle-Chicago Community Trust Scholar (2005)

  • Edward Mallinckrodt, Jr. Foundation Fellow (2004)

  • HHMI Life Science Research Foundation (LSRF) Fellow The Rockefeller University (1998)

  • Charles H. Revson Fellow in Biomedical Research The Rockefeller University (1997)

  • Distinguished Student Commencement Speaker AwardSloan Kettering Institute-Cornell University Medical College, New York, NY (1997)

Professional Service

  • President, Division E (Immunology) American Society of Microbiology (2015)

  • Standing member, Immunity and Host Defense (IHD) Study Section NIAID, NIH (2013 - 2015)

International Activity

  • German Research Foundation (DFG)
 Bonn, Germany (2013)

    International Reviewer, Life Sciences 2 Programme

  • French National Research Agency (ANR) Paris, France (2012)

    International Reviewer, Programme Blanc International

  • Health Research Board of Ireland (HRB) Dublin, Ireland (2011)

    International Reviewer, Translational Medicine Fellowships Programme

  • European Research Council (ERC) Brussels, Belgium (2011)

    International Reviewer, European Union 7th Research Framework Advanced Grants Programme (FP7)

  • Medical Research Council (MRC) London, United Kingdom (2009)

    International Reviewer, Strategic Grants Programme

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Contact Info

John D MacMicking, PhD
Mailing Address
Boyer Center for Molecular MedicineSection of Microbial Pathogenesis
333 Cedar Street

New Haven, CT 06536-0812