Herve Francois Agaisse MSc, PhD
Associate Professor of Microbial Pathogenesis
Host/pathogen interaction, microorganisms; infection; cell-to-cell spread; Listeria; Shigella; Chlamydia; Rickettsia; Vaccinia; Drosophila melanogaster; immune response; stem cells; JAK/STAT signaling; aging
Intracellular pathogens, such as Listeria, Shigella, Rickettsia, and Vaccinia virus, display actin-based motility and spread from cell to cell through the
formation of plasma membrane protrusions. Although several virulence factors involved in actin-based motility have been identified, their interaction with the host cell machinery is still poorly understood. We have developed systematic
approaches to determine the host cell factors required for intracellular pathogen spread in human cells. The approach may not only lead to the identification of mechanisms underlying microbial pathogenesis, but may also uncover the native
function of the identified host factors. An additional focus of the lab is to determine the role of cytokine signaling in the maintenance of epithelium integrity
and the control of the rate of stem cell division in response to bacterial infection. The approach may lead to the identification of evolutionary conserved signaling mechanisms linking environmental challenges and stem cell division.