Frederick J. Sigworth PhD

Professor of Cellular and Molecular Physiology and of Biomedical Engineering

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Medicine, Pharmacology, and Physiology | Biochemistry, Biophysics and Structural Biology

Office of Student Research

School of Engineering and Applied ScienceHigh Performance ComputationInterdepartmental Neuroscience ProgramCellular & Molecular Physiology: Membrane Proteins - Ion Channels; Membrane Biophysics; Membrane Protein Structure; Graduate Program in Cellular and Molecular Physiology

Research Interests

Cell Physiology; Electron Microscopy; Electrophysiology; Ion Channel; Mathematical Model; Patch Clamp; Potassium Channel; Protein Structure; Sodium Channel; Voltage Gated Channel; Xenopus Oocyte more...


  • Ph.D., Yale University, 1979

Selected Publications

  • Wang L and Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature, 461(7261):292-5, 2009.
  • Singer A, Coifman RR, Sigworth FJ, Chester DW, Shkolnisky Y. Detecting consistent common lines in cryo-EM by voting. J Struct Biol. 2009 Nov 17. [Epub ahead of print]
  • Weerakoon, P.; Sigworth, F.; Culurciello, E.. Integrated patch-clamp biosensor for high-density screening of cell conductance. Electronics Letters, 44:81-82, 2008.



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