Fred Gorelick MD

Professor of Medicine (Digestive Diseases) and of Cell Biology; Deputy Director, Yale M.D., Ph.D. Program

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

LCME Academic Environment Subcommittee

Office of Student ResearchCell Biology: Membrane TrafficInternal Medicine: Digestive Diseases

Research Interests

Exocrine pancreas; Pancreatitis; Intracellular proteolysis; Vacuolar ATPase; AMPK; Protein kinase C more...


  • M.D., University of Missouri, 1973

Selected Publications

  • Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. Shugrue CA, Alexandre M, de Villalvilla AD, Kolodecik TR, Young LH, Gorelick FS, Thrower EC. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G723-32
  • Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS. PLoS One. 2012;7(7):e41320
  • Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. Low extracellular pH modulates calcium signaling in the pancreatic acinar cell. J. Biological Chemistry 2011 286(3):1919-26 PMC330423



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