Craig M Crews, PhD

Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry; Executive Director, Yale Center for Molecular Discovery

Research Interests

Ambystoma mexicanum; Biochemistry; Biology; Chemistry; Cell Biology; Neoplasms; Pharmacology; Regeneration; Drugs, Investigational; Developmental Biology; Proteasome Endopeptidase Complex; Proteasome Inhibitors

Research Organizations

Secondary Faculty

Postnatal Development & Regeneration

Developmental Therapeutics

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology: Cell Cycle and Signal Transduction; Drug Design, Discovery and Mechanism

Stem Cell Center, Yale: Stem Cells and Tissue Repair

Cancer Center, Yale: Developmental Therapeutics

Diabetes Research Center

Office of Cooperative Research

Research Summary

We use a combination of biochemistry, molecular biology, and bio-organic chemistry to explore different aspects of developmental and cell biology. Different projects include 1) the exploration of how biologically active compounds from nature work in order to identify new probes for cell biology as well as identify novel drug targets and 2) the development of novel small molecules to control intracellular protein homeostasis.

Extensive Research Description

We develop novel reagents, which will allow us to explore new areas in cell biology. This 'chemical genetic' approach uses biologically active natural products and de novo designed small molecules to identify critical components in intracellular processes. In the past few years, our efforts have focused on anti-angiogenic, antitumor and anti-inflammatory natural products. More recently, we have explored the use of small molecules to control intracellular protein levels, either by inhibiting their degradation or by inducing their proteolysis via the 26S proteasome. A goal of this research is to develop novel methodologies that would allow for small molecule control of the 'undruggable proteome'.

Selected Publications

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