Chris Cotsapas PhD

Assistant Professor of Neurology and of Genetics

Research Interests

Genetics; Computational biology; Cell-based approaches to discover and understand the mechanisms that give rise to disease; Disorders of the immune system and brain

Research Summary

We look for genetic factors that predispose to disease and try to understand the biology they perturb. We ask what genes are perturbed, what processes they participate in and whether these perturbations are sufficient to induce differences at the molecular and cellular levels.This gives us novel targets for biomarkers, diagnosis and treatment.

Our approach encompasses statistical and computational tools, genetics and molecular biology. We are a hybrid lab with strong quantitative and experimental skills and we cycle between hypotheses generated by rigorous analysis and confirmation and discovery in experimental systems.

Selected Publications

  • Immune-mediated disease genetics: the shared basis of pathogenesis. Cotsapas C, Hafler DA. Trends Immunol. 2013 Jan;34(1):22-6. doi: 10.1016/ Epub 2012 Sep 29. Review.
  • Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Neurology. 2013 Sep 10;81(11):956-63. doi: 10.1212/WNL.0b013e3182a43b48. Epub 2013 Aug 6.

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