Chuck V Sindelar, PhD

Assistant Professor of Molecular Biophysics and Biochemistry

Research Interests

Adenosine Triphosphate; Biochemistry; Biophysics; Kinesin; Crystallography, X-Ray; Cryoelectron Microscopy

Research Organizations

Faculty Research

Structural Biology

Office of Cooperative Research

Research Summary

My more recent work has turned towards advancing cryo-electron microscopy techniques to the point where atomic-level features can be obtained for systems such as cytoskeletal filaments. These efforts led to my recent synthesis, using cryo-electron microscopy (cryo-EM) and X-ray crystallography information, of an atomic-level model for kinesin’s ATP-sensing machinery in its active form, which is only assumed following microtubule attachment. This discovery led to a simple and intuitive “seesaw” mechanism describing how ATP binding leads to force generation in the microtubule-attached motor. My laboratory's research interests are rapidly expanding to include numerous other filament-related molecular machines, such the myosin molecular motor that powers muscle movement, and diverse protein machinery involved in DNA repair and splicing.

Selected Publications

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