Computational Biology and Bioinformatics Faculty

James Aspnes

Professor of Computer Science

Kei-Hoi Cheung

Associate Professor of Anesthesiology (Medical Informatics) and of Genetics

Research Interests:Genetic database and tool interpolation

Ronald Coifman

Phillips Professor of Mathematics and Professor of Computer Science

Chris Cotsapas

Assistant Professor of Neurology and of Genetics

Research Interests:We use genetics, computational biology and cell-based approaches to discover and understand the mechanisms that give rise to disease. We are particularly interested in disorders of the immune system and brain.

Forrest Crawford

Assistant Professor of Public Health (Biostatistics)

Xing Wang Deng

Daniel C. Eaton Professor of Molecular, Cellular, and Developmental Biology
Daniel C. Eaton Professor of Plant Biology at Yale
Director of Peking-Yale Center for Plant Molecular Genetics & Agrobiotechnology

Research Interests:Plant Biology, Genome and Epigenome, Development mechanism, Hybrid Vigor, Agribiotechnology Light Regulation

Thierry Emonet

Associate Professor of Molecular, Cellular, and Developmental Biology and of Physics

Research Interests:Computational Biology chemotaxis, olfaction, immunology

Donald Engelman

Eugene Higgins Professor of Molecular Biophysics and Biochemistry

Research Interests:Helix Interactions; Lipid Bilayers; Membranes; Physical Biochemistry; Protein Folding; Proteins

Alison Galvani

Associate Professor of Epidemiology (Microbial Diseases) and of Ecology and Evolutionary Biology

Research Interests:Applications of epidemiology and evolutionary ecology in the study of numerous diseases

Mark Gerstein

Albert L. Williams Professor of Biomedical Informatics
Co-Director, Yale Computational biology and Bioinformatics Program

Research Interests:Biochemistry; Bioinformatics; Biophysics; Computational Biology; DNA; Genomics; Molecular Simulation; Proteins; Sequence Alignment; Structural Biology

Antonio Giraldez

Associate Professor of Genetics
Member of the Yale Cancer Center
Member of the Stem Cell Center
Director of Graduate Studies

Research Interests:Non-coding RNAs, Post-transcriptional regulation; microRNAs; Developmental Biology; Gene regulatory networks; Systems Biology; Zebrafish

William Jorgensen

Sterling Professor of Chemistry
Director, Division of Physical Sciences & Engineering

Kenneth Kidd

Professor of Genetics, of Ecology and Evolutionary Biology and of Psychiatry

Research Interests:Complex Human Disorders; Neuropsychiatric Disorders; Human Population ; Genetics; Human Evolution

Tae Hoon Kim

Assistant Professor of Genetics
Member, Yale Cancer Center
Member, Yale Stem Cell Center

Research Interests:Transcriptional Regulatory Elements and Chromatin Structure; Expression of the Cancer Genome; Epigenomics

Steven Kleinstein

Associate Professor of Pathology

Research Interests:Computational immunology; Systems biology; Disease/tissue/pathway/process modeling and simulation; Statistical and model-based analysis of experimental and clinical data

Yuval Kluger

Associate Professor of Pathology

Research Interests:Signal processing and dimensional reduction of genome-wide data; Local and non-local genomic pattern recognition; Identification of cancer subclones with proliferation and invasion potential in heterogeneous cancer biopsies

Michael Krauthammer

Associate Professor of Pathology

Research Interests:Molecular interaction networks: computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology: term identification, information extraction

Paul Lizardi

Professor of Pathology

Research Interests:Cancer Genetics/Epigenetics; Cancer biology; Dynamics of abnormal chromatin states in neoplasia and metastasis; DNA amplification technology (MDA, RCA); DNA microarray technology for epigenetic analysis, array-CGH; Proteomics analysis of cancer tissues

Elias Lolis

Professor of Pharmacology
Director of Graduate Studies

Research Interests:Cancer; Inflammation; Infectious disease; macromolecular X-ray crystallography; Signaling pathways; Drug design; High throughput screening (HTPS)

Shuangge Steven Ma

Associate Professor of Public Health (Biostatistics)

Research Interests:Bioinformatics; Survival analysis; Semiparametric methods; Cancer study; Mental disorders; Health economics

Perry Miller

Professor of Anesthesiology (Medical Informatics)

Research Interests:Biomedical informatics; Clinical informatics; Bioinformatics; Neuroinformatics

Andrew Miranker

Professor of Molecular Biophysics and Biochemistry

Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils

James Noonan

Assistant Professor of Genetics
Member, Kavli Institute for Neuroscience
Member, Yale Cancer Center

Research Interests:Human Evolution; Evolutionary Dynamics of Gene Regulation; Synthetic Biology; Applications of Ultra-High Throughput Sequencing Technologies; Comparative and Functional Genomics in Vertebrates

Corey O'Hern

Associate Professor of Mechanical Engineering and of Physics
Assoc Prof Dept of Mechanical Engineering & Materials Science and Physics
Associate Professor

Research Interests:protein-protein interactions; intrinsically disordered proteins; active media; cell motion; wound healing in epithelial tissue; molecular dynamics simulations; statistical mechanics; Markov state modeling

Anna Marie Pyle

William Edward Gilbert Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry
Director, Division of Biological Sciences

Research Interests:Structure and function of catalytic RNA; RNA helicase mechanisms; Computational analysis of RNA structure

Lynne Regan

Professor of Molecular Biophysics and Biochemistry and of Chemistry

Research Interests:Mental retardation; protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); protein-based nanomaterials

Valerie Reinke

Associate Professor of Genetics

Research Interests:Functional genomic analysis of global gene expression mechanisms; C. elegans germline development; germline stem cells

Martin Schultz

Arthur K. Watson Professor Emeritus of Computer Science

Gordon Shepherd

Professor of Neurobiology

Research Interests:Neurons; Synapses; Nervous system

Dieter Soll

Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry

Research Interests:Aminoacyl-tRNA Synthesis; Functional Genomics; Life Science Biological; Mechanism of Translation

Jeffrey Townsend

Assistant Professor of Ecology and Evolutionary Biology
Asst Prof Ecology/Evolutionary Biology

Gunter Wagner

Alison Richard Professor of Ecology and Evolutionary Biology

Research Interests:evolution of development gene regulation molecular evolution transcription factor evolution uterus function and evolution parturition limb development

Zuoheng Anita Wang

Assistant Professor of Public Health (Biostatistics)

Research Interests:Statistical Genetics; Bioinformatics; Genomics

Heping Zhang

Susan Dwight Bliss Professor of Public Health (Biostatistics) and Professor in the Child Study Center and of Statistics

Research Interests:Biostatistics; Genomics; Epidemiology; Psychiatry; Pregnancy; Infertility; Substance Use; Bioinformatics

Jing Zhang

Assistant Professor of Statistics

Hongyu Zhao

Ira V. Hiscock Professor of Public Health (Biostatistics) and Professor of Genetics and of Statistics

Research Interests:statistical genomics; computational biology; genetic epidemiology; genome wide association studies; complex diseases; risk prediction; high dimensional data; dimension reduction; network models; graphical models; bioinformatics; next generation sequencing analysis; cancer genomics; epigenetics; herbal medicine; microbiome; proteomics

Steven Zucker

David and Lucille Packard Professor of Computer Science and Professor of Biomedical Engineering