Molecular Medicine, Pharmacology, and Physiology

Anderson, Karen

Research Interests:Enzyme function; Anti-viral agents

Aronson, Peter

Research Interests:Urinary electrolyte excretion; cell membrane ion exchangers; proximal tubule

Research Interests:Sensory physiology; Biophysics; Biochemistry; Neuroscience; Electrophysiology; Polymodal ion channels; Temperature-sensitive ion channels; Mechanosensitive ion channels; Two-pore potassium channels; Ion channel pharmacology

Bale, Allen

Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor

Beardsley, George

Research Interests:Biology of Osteosarcoma; Molecular enzymology of purine biosynthesis indicators for osteosarcoma; Molecular Pharmacology of anticancer and antiviral drugs which alter DNA structure; Biochemical Pharmacology of antifolate drugs; Development of novel antifolates

Ben Mamoun, Choukri

Research Interests:Malaria

Bender, Jeffrey

Research Interests:Inflammatory, Immune, Metabolic and Hormonal Effects on the Endothelium

Bennett, Anton

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

Bordey, Angelique

Research Interests:Neurogenesis; stem cells; mTOR; Neural stem cell; Cognitive functions; autism

Bosenberg, Marcus

Research Interests:Melanocytic neoplasms; soft tissue tumors; cutaneous lymphoma; genodermatoses

Boulpaep, Emile

Research Interests:Electrical properties of membrane proteins in plasma membranes and junctions of renal tubule cells

Braddock, Demetrios

Research Interests:Structural biology; Hematopathology; Genitourinary Pathology

Brash, Douglas

Research Interests:Ultraviolet Light; Skin Cancer

Brown, Thomas

Research Interests:Neurobiological mechanism of learning and memory.

Bucala, Richard

Research Interests:Mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology; Emergence of steroid resistance; Biochemical, biological, and genetic characterization of the MIF cytokine family; MIF's role in malaria and global infectious diseases; Pharmacologic immuniomodulation of the MIF pathway; Role of fibrocytes in different systemic fibroses

Campbell, Stuart

Canessa, Cecilia

Research Interests:Renal Function; Epithelial Sodium Channels

Cantley, Lloyd

Research Interests:Nephrology; physiology and integrative medical biology; epithelial cell migration and morphogenesis; epithelial cell adhesion; migration; branching tubulogenesis

Caplan, Michael

Research Interests:Ion pumps in polarized epithelia; Sorting and function

Carrasco, Nancy

Chang, Sandy

Research Interests:Mouse models of cancer; DNA damage; Telomere biology

Cheng, Yung-Chi

Research Interests:Cancer; Viral chemotherapy; Chinese herbs; Chinese medicine

Cho, Judy

Research Interests:Inflammatory Bowel Disease (IBD); identifying genetic variation that affects susceptibility to and expression of Inflammatory Bowel Disease (IBD)

Cohen, Lawrence

Research Interests:Brain; Central Nervous System; Neurons; Vertebrate Physiology; Olfaction; Olfactory Bulb; Protein Sensors of Voltage and Calcium

Costa, Jose

Research Interests:Oncology; Carcinogenesis; Tumor development and progression; Advanced diagnostics; Molecular diagnostics; Diagnosed genetic alterations in tumors; Cancer risk detection by mutational load distribution analysis

Craft, Joseph

Research Interests:Arthritis; Autoimmunity; Cytokines; Diseases and Disorders; Lupus; T Cell Differentiation; T Cells; Tolerance

Dhodapkar, Madhav

Research Interests:Myeloma and related plasma cell disorders; human immune system's interaction with growing tumors in patients; preneoplastic monoclonal gammopathy and multiple myeloma, tumor and host related factors

DiGiovanna, Michael

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; estrogen receptor, signal transduction

Duman, Ronald

Research Interests:Depression; Antidepressants; Stress; Molecular biology; Neuropharmacology Signal transduction pathways; Gene expression; Identifying the molecular and cellular adaptations that underlie the actions of psychotropic drugs and stress

Egan, Marie

Research Interests:Cystic fibrosis clinical studies; Cystic fibrosis basic science research (ion transport, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function); Cystic fibrosis translational research studies (strategies to bypass the basic defect)

Ehrlich, Barbara

Research Interests:Intracellular calcium regulation

Eichmann, Anne

Research Interests:vascular development and angiogenesis; guidance of vascular patterning; tip cells; axonal growth cones; vascular growth factors in the nervous system

Elias, Jack

Research Interests:Cell and Molecular biology of lung injury and repair; Asthma; COPD; Pulmonary fibrosis; acute lung injury; Cytokines; Inflammation; Internal Medicine; Pulmonary Diseases; Transgenic mice; genetically modified mice; Emphysema; Fibrosis; Inflammation

Ellman, Jonathan

Research Interests:proteases, phosphatases, inhibitors, C-H functionalization, asymmetric amine synthesis

Eswarakumar, V.

Research Interests:Fibroblast Growth Factor Receptors (FGFRs)

Forbush, Biff

Research Interests:Membrane Proteins; Epithelial Transport; Ion Transport; Na-K-Cl Cotransporter; Nerve Cells; Muscle Cells

Geibel, John

Research Interests:Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease, electrophysiology; CFTR; AMPKinase volume regulation

Gracheva, Elena

Research Interests:Sensory physiology, molecular adaptations, hibernation, thermoregulation, ion channels, neuroscience

Greco, Valentina

Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; cancer

Grutzendler, Jaime

Research Interests:Two-photon microscopy; Neurodegeneration; Alzheimer's; Blood-brain barrier; Microvasculature; Synapses; Neuroinflammation; Microglia; Astrocyte; Endothelium, myelin imaging

Ha, Ya

Research Interests:Membrane protein; X-ray crystallography; Enzyme mechanism

Hattangadi, Shilpa

Research Interests:Terminal erythroid development, hematopoiesis; bone marrow failure; red cell aplasia; chromatin condensation; nuclear protein export; proteomics; genomics; transcriptional regulation; histone modification; post-transcriptional modification of hematopoietic regulators

Hodsdon, Michael

Research Interests:Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology

Hurwitz, Michael

Research Interests:Cell migration; Kinase signaling; Phosphorylation; Cytoskeleton; Engulfment; Apoptosis; C. elegans; Cancer biology

Jordt, Sven-Eric

Research Interests:Sense of touch and pain in humans and animals; Chemosensory processes in sensory neurons and their role in chemical environmental exposures; Neural sensitization in asthma; Hypersensitivity disorders

Kaczmarek, Leonard

Research Interests:Neuroscience; Learning and memory; Ion channels

Karatekin, Erdem

Research Interests:Membrane fusion, exocytosis, secretory vesicle dynamics, fluorescence microscopy, image analysis, microfluidics, supported bilayers, proteoliposomes

Katz, Samuel

Kazmierczak, Barbara

Research Interests:Pseudomonas aeruginosa; Staphylococcus aureus; innate immunity; host-pathogen interactions; mucosal immunity

Kibbey, Richard

Research Interests:Mechanisms of insulin secretion by beta-cells; pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; mitochondria

Kluger, Yuval

Research Interests:Signal processing and dimensional reduction of genome-wide data; Local and non-local genomic pattern recognition; Identification of cancer subclones with proliferation and invasion potential in heterogeneous cancer biopsies

Krause, Diane

Research Interests:Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia

Krauthammer, Michael

Research Interests:Molecular interaction networks: computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology: term identification, information extraction

Kupfer, Gary

Research Interests:Genomic instability; Development of cancer; Genetic syndrome Fanconi anemia (FA); Viral protein enhancement of cancer therapeutics

Kyriakides, Themis

Research Interests:Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Gene delivery; Biomaterials

Lister, George

Lizardi, Paul

Research Interests:Cancer Genetics/Epigenetics; Cancer biology; Dynamics of abnormal chromatin states in neoplasia and metastasis; DNA amplification technology (MDA, RCA); DNA microarray technology for epigenetic analysis, array-CGH; Proteomics analysis of cancer tissues

Lolis, Elias

Research Interests:Cancer; Inflammation; Infectious disease; macromolecular X-ray crystallography; Signaling pathways; Drug design; High throughput screening (HTPS)

Madri, Joseph

Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell-Endothelial cell interactions

Maihle, Nita

Research Interests:Cancer; Women's cancers; Diagnostics; Theragnostics; Biotherapeutics; Precision/personalized medicine, signal transduction; EGFR/ERBB/HER-driven adult solid tumors

Martin, Kathleen

Research Interests:vascular smooth muscle; differentiation; signal transduction; transcription; translation

Means, Robert

Research Interests:Viruses; Immune responses; AIDS-associated cancers; KSHV; Adverse pregnancy events; Oncogenesis; Cancer metabolism; Tumor virology; Herpesviruses

Min, Wang

Research Interests:Inflammation; Angiogenesis/lymphangiogenesis; Atherosclerosis; Transplant rejection; Tumor microenvironment and metastasis

Miranker, Andrew

Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils

Mistry, Pramod

Research Interests:Gaucher's disease: Molecular genetics, Genotype/phenotype correlations modifier genes, Animal models and therapies; Wilson's disease; Glycogen storage disease type 1a

Morrow, Jon

Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

Nairn, Angus

Research Interests:Dopaminergic signal transduction; Structure and function of protein kinases and phosphatases

Nathanson, Michael

Research Interests:Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus

Nguyen, Don

Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

Nitabach, Michael

Research Interests:Neurophysiology; Molecular genetics; Systems Physiology; Animal Behavior

Paintsil, Elijah

Research Interests:HIV translational research; cellular pharmacology of HIV-RT inhibitors in relation to clinical toxicities; Fitness and evolution of HIV drug resistant mutants; Molecular epidemiology and dynamics of HIV/HCV transmission

Picciotto, Marina

Research Interests:Neuroscience; Molecular basis of behavior; Intracellular signaling; Mouse genetic models

Pieribone, Vincent

Research Interests:Neurophysiology; Neurotransmission; Voltage dye imaging; Sensory physiology; Drug development; Coral biology; Fluorescent proteins

Pober, Jordan

Research Interests:Immunobiology of vascular endothelial cells: cytokine actions and mechanisms; transplantation immunology

Politi, Katerina

Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

Qyang, Yibing

Research Interests:Heart; Stem cell; ES cell; iPS cell; Physiology; Tissue engineering; Small molecule; Patient; Disease; Cardiovascular

Rimm, David

Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

Rinehart, Jesse

Research Interests:Ion Transport; Kinase/Kinome Interactions in Physiological Systems; System-Wide & Targeted Phosphoproteomics; Protein Engineering

Robek, Michael

Research Interests:Virus-host interactions; viral immunology; hepatitis viruses; interferon

Rockwell, Sara

Research Interests:Microenvironmental heterogeneity in solid tumors; Experimental cancer therapy; Biological effects of ionizing radiation; Effects of hypoxia and low pH

Rodeheffer, Matthew

Research Interests:Genomics; Stem Cells

Roth, Robert, Jr

Research Interests:Neurotransmitter function; Psychotropic drugs; Catecholamine-containing neurons

Rudnick, Gary

Research Interests:Neurotransmitter recycling; Mechanism of membrane transport

Saltzman, W. Mark

Research Interests:Bio-compatible polymers, drug delivery systems

Santos-Sacchi, Joseph

Research Interests:Mammalian inner ear

Sessa, William

Research Interests:Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis

Shadel, Gerald

Research Interests:Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling

Shlomchik, Mark

Research Interests:Autoimmunity; Blood or Blood Products or Transfusions; Bone Marrow Transplantation; Immunobiology; Immunology; Immunopathology; Immunotherapy; Lymphocytes; Transgenic Animals

Shulman, Gerald

Research Interests:Molecular mechanisms responsible for insulin resistance

Sigworth, Frederick

Research Interests:Cell Physiology; Electron Microscopy; Electrophysiology; Ion Channel; Mathematical Model; Patch Clamp; Potassium Channel; Protein Structure; Sodium Channel; Voltage Gated Channel; Xenopus Oocyte

Simons, Michael

Research Interests:Angiogenesis; Arteriogenesis; Lymphangiogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis

Singh, Satinder

Research Interests:Chemical neurotransmission; Neuropsychiatric disease; Epilepsy; Neuropharmacology; Biogenic amine; Gamma-aminobutyric acid; Neurotransmitter transporter; Antidepressant; Structural neurobiology; X-ray crystallography; Transporter kinetics

Sklar, Jeffrey

Research Interests:Molecular biology of human disease, especially cancer; Molecular biologic methods of disease diagnosis; Cancer-related genes and their functions in neoplasia and normal cellular physiology; Chromosomal structure and chromosomal abnormalities in genetic and neoplastic disorders; Immunogenetics

Slayman, Clifford

Research Interests:Charge-dependent Transport; Proton Pumps; Potassium channels; Ribosomally Synthesized AntiMicrobial Peptides (RAMPs)

Somlo, Stefan

Research Interests:Genetic kidney and liver disease; Cilia function in tissue homeostasis; Polycystin function

Spiegel, David

Research Interests:Design of novel molecules that enhance the recognition of various pathogens, including viruses, by the human immune system

Stern, David

Research Interests:Cancer Biology: signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma

Tomita, Susumu

Research Interests:Synaptic transmission; Brain; Biochemistry; molecular biology; immunocytochemistry; gene-targeted animals; electrophysiology

Turk, Benjamin

Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering

Wajapeyee, Narendra

Research Interests:Cancer; Genomics; RNAi; Senescence; DNA methylation; RNAi delivery to cancer cells

Walther, Zenta

Research Interests:epithelial polarity and proliferation control; intestinal epithelial homeostasis; intestinal barrier function; innate immune signalling

Waxman, Stephen

Research Interests:Axons; Electrophysiology; Genes; Ion Channels; Molecular Biology; Multiple Sclerosis; Pain Syndromes; Sodium Channels; Spinal Cord Injury; Stroke

Weissman, Sherman

Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics