Molecular Medicine, Pharmacology, and Physiology

Ameen, Nadia Annitia

Research Interests:Apical endocytosis and exocytosis; Protein traffic; Secretory diarrhea; Cystic fibrosis

Anderson, Karen S

Research Interests:Enzyme function; Anti-viral agents

Aronson, Peter S.

Research Interests:Urinary electrolyte excretion; Cell membrane ion exchangers; Proximal tubule

Bagriantsev, Slav

Research Interests:Sensory physiology; Biophysics; Biochemistry; Neuroscience; Electrophysiology; Polymodal ion channels; Temperature-sensitive ion channels; Mechanosensitive ion channels; Two-pore potassium channels; Ion channel pharmacology

Bale, Allen Everett

Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor

Beardsley, George Peter

Research Interests:Biology of Osteosarcoma; Molecular enzymology of purine biosynthesis indicators for osteosarcoma; Molecular Pharmacology of anticancer and antiviral drugs which alter DNA structure; Biochemical Pharmacology of antifolate drugs; Development of novel antifolates

Ben Mamoun, Choukri

Research Interests:Malaria

Bender, Jeffrey R.

Research Interests:Inflammatory, Immune, Metabolic and Hormonal Effects on the Endothelium

Bennett, Anton M.

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

Bindra, Ranjit S.

Research Interests:DNA repair; Translational research; Clinical trials with experimental therapeutics; High-throughput drug screening

Bordey, Angelique

Research Interests:Neurogenesis; stem cells; mTOR; Neural stem cell; Cognitive functions; autism

Bosenberg, Marcus W.

Research Interests:Melanocytic neoplasms; Soft tissue tumors; Cutaneous lymphoma; Genodermatoses

Boulpaep, Emile Louis Jean Bapti

Research Interests:Electrical properties of membrane proteins in plasma membranes and junctions of renal tubule cells

Braddock, Demetrios

Research Interests:Structural biology; Hematopathology; Genitourinary Pathology

Brown, Thomas H

Research Interests:Neurobiological mechanism of learning and memory.

Bucala, Richard

Research Interests:Mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology; Emergence of steroid resistance; Biochemical, biological, and genetic characterization of the MIF cytokine family; MIF's role in malaria and global infectious diseases; Pharmacologic immuniomodulation of the MIF pathway; Role of fibrocytes in different systemic fibroses

Canessa, Cecilia

Research Interests:Renal Function; Epithelial Sodium Channels

Cantley, Lloyd Garnet

Research Interests:Nephrology; Acute Kidney Injury; Physiology and integrative medical biology; Epithelial cell migration and morphogenesis; Epithelial cell adhesion; Migration; Branching tubulogenesis

Caplan, Michael J

Research Interests:Ion pumps in polarized epithelia; Sorting and function

Chang, Sandy

Research Interests:Mouse models of cancer; DNA damage; Telomere biology

Cheng, Yung-Chi

Research Interests:Cancer; Viral chemotherapy; Chinese herbs; Chinese medicine

Cohen, Lawrence Baruch

Research Interests:Brain; Central Nervous System; Neurons; Vertebrate Physiology; Olfaction; Olfactory Bulb; Protein Sensors of Voltage and Calcium

Costa, Jose

Research Interests:Oncology; Carcinogenesis; Tumor development and progression; Advanced diagnostics; Molecular diagnostics; Diagnosed genetic alterations in tumors; Cancer risk detection by mutational load distribution analysis

Craft, Joseph Edgar

Research Interests:Autoimmunity; Cytokines; Lupus; T Cell Differentiation; Tolerance

Dhodapkar, Madhav V.

Research Interests:Myeloma and related plasma cell disorders; Human immune system's interaction with growing tumors in patients; Preneoplastic monoclonal gammopathy and multiple myeloma, tumor and host related factors

DiGiovanna, Michael P

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; Estrogen receptor; Signal transduction; Breast cancer clinical trials

Egan, Marie E

Research Interests:Cystic fibrosis clinical studies; Cystic fibrosis basic science research (ion transport, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function); Cystic fibrosis translational research studies (strategies to bypass the basic defect)

Ehrlich, Barbara E

Research Interests:Intracellular calcium regulation

Eichmann, Anne

Research Interests:Vascular development and angiogenesis; Guidance of vascular patterning; Tip cells; Axonal growth cones; Vascular growth factors in the nervous system

Ellman, Jonathan A

Research Interests:proteases, phosphatases, inhibitors, C-H functionalization, asymmetric amine synthesis

Eswarakumar, Jacob V.P.

Research Interests:Fibroblast Growth Factor Receptors (FGFRs)

Fernandez-Hernando, Carlos

Research Interests:Cholesterol homeostasis; Lipoprotein metabolism; Post-transcriptional regulation; microRNAs; Atherosclerosis; RNAi screening

Finberg, Karin Elisabeth

Research Interests:Human Genetics; Genetic and Acquired Disorders of Systemic Iron Balance; Hepcidin Regulation; Hepatic BMP/SMAD Signaling.

Forbush, Biff

Research Interests:Membrane Proteins; Epithelial Transport; Ion Transport; Na-K-Cl Cotransporter; Nerve Cells; Muscle Cells

Geibel, John P

Research Interests:Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease; electrophysiology; CFTR; AMPKinase volume regulation

Gracheva, Elena

Research Interests:Sensory physiology; Molecular adaptations; Hibernation; Thermoregulation; Ion channels; Neuroscience

Greco, Valentina

Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; Cancer

Grutzendler, Jaime

Research Interests:Neuro-glio-vascular interactions, cerebral blood flow and metabolism blood-brain barrier, two-photon microscopy, myelin imaging, synaptic plasticity, development and pathology of the brain microvasculature, Neuroinflammationin, neurodegenerative diseases and stroke

Ha, Ya

Research Interests:Membrane protein; X-ray crystallography; Enzyme mechanism

Hattangadi, Shilpa

Research Interests:Terminal erythroid development; Hematopoiesis; Bone marrow failure; Red cell aplasia; Chromatin condensation; Nuclear protein export; Proteomics; Genomics; Transcriptional regulation; Histone modification; Post-translational modification of hematopoietic regulators

Hodsdon, Michael Edwin

Research Interests:Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology

Jensen, Ryan B.

Research Interests:Cancer biology; DNA repair; BRCA2; DNA damage signaling; Genomic instability

Kaczmarek, Leonard Konrad

Research Interests:Neuroscience; Learning and memory; Ion channels

Karatekin, Erdem

Research Interests:Membrane fusion; Exocytosis; Secretory vesicle dynamics; Fluorescence microscopy; Image analysis; Microfluidics; Supported bilayers; Proteoliposomes

Kazmierczak, Barbara Irene

Research Interests:Pseudomonas aeruginosa; Staphylococcus aureus; Innate immunity; Host-pathogen interactions; Mucosal immunity

Kibbey, Richard Glenn

Research Interests:Mechanisms of insulin secretion by beta-cells; Pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; Mitochondria

Kluger, Yuval

Research Interests:Signal processing and dimensional reduction of genome-wide data; Local and non-local genomic pattern recognition; Identification of cancer subclones with proliferation and invasion potential in heterogeneous cancer biopsies

Krause, Diane S

Research Interests:Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia

Krauthammer, Michael Oliver

Research Interests:Molecular interaction networks, computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology, term identification, information extraction

Kupfer, Gary

Research Interests:Genomic instability; Development of cancer; Genetic syndrome Fanconi anemia (FA); Viral protein enhancement of cancer therapeutics

Kyriakides, Themis

Research Interests:Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Gene delivery; Biomaterials

Lolis, Elias

Research Interests:Cancer; Inflammation; Infectious disease; Macromolecular X-ray crystallography; Signaling pathways; Drug design; High throughput screening (HTPS)

Min, Wang

Research Interests:Inflammation; Angiogenesis/lymphangiogenesis; Atherosclerosis; Transplant rejection; Tumor microenvironment and metastasis

Miranker, Andrew D

Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils

Mistry, Pramod Kumar

Research Interests:Gaucher's disease; Molecular genetics; Genotype/phenotype correlations modifier genes; Animal models and therapies; Wilson's disease; Glycogen storage disease type 1a

Morrow, Jon Stanley

Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

Nairn, Angus Clark

Research Interests:Dopaminergic signal transduction; Structure and function of protein kinases and phosphatases

Nathanson, Michael Harris

Research Interests:Mechanisms and effects of calcium signals in polarized epithelia; Effect of spatial organization of calcium signals on organ function regulation; Factors that organize Ca2+ waves in hepatocytes; Organization and effects of Ca2+ waves in cholangiocytes; Mechanisms and effects of Ca2+ signals in the nucleus

Nguyen, Don

Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

Nitabach, Michael N

Research Interests:Neurophysiology; Molecular genetics; Systems Physiology; Animal Behavior

Paintsil, Elijah

Research Interests:HIV translational research; Cellular pharmacology of HIV-RT inhibitors in relation to clinical toxicities; Fitness and evolution of HIV drug resistant mutants; Molecular epidemiology and dynamics of HIV/HCV transmission

Picciotto, Marina

Research Interests:Neuroscience; Molecular basis of behavior; Intracellular signaling; Mouse genetic models

Pieribone, Vincent Allen

Research Interests:Neurophysiology; Neurotransmission; Voltage and calcium imaging; Sensory physiology; Drug development; Coral biology; Fluorescent proteins

Pober, Jordan Stuart

Research Interests:Immunobiology of vascular endothelial cells; Cytokine actions and mechanisms; Transplantation immunology

Politi, Katerina

Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

Qyang, Yibing

Research Interests:Heart; Stem cell; ES cell; iPS cell; Physiology; Tissue engineering; Small molecule; Patient; Disease; Cardiovascular

Rimm, David L

Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

Rinehart, Jesse

Research Interests:Physiological Systems; Protein Phosphorylation; Cell Signaling; Phosphoproteomics; Protein Engineering; Ion Transport; Synthetic Biology; Translational Research

Rodeheffer, Matthew S

Research Interests:Genomics; Stem Cells

Roth, Robert Henry, Jr

Research Interests:Neurotransmitter function; Psychotropic drugs; Catecholamine-containing neurons

Rudnick, Gary

Research Interests:Neurotransmitter recycling; Mechanism of membrane transport

Saltzman, W. Mark

Research Interests:Bio-compatible polymers, drug delivery systems

Santos-Sacchi, Joseph

Research Interests:Mammalian inner ear

Sessa, William C.

Research Interests:Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis

Shadel, Gerald S

Research Interests:Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling

Shulman, Gerald I

Research Interests:Cellular and molecular mechanisms responsible for insulin resistance.

Sigworth, Frederick J.

Research Interests:Cell Physiology; Electron Microscopy; Electrophysiology; Ion Channel; Mathematical Model; Patch Clamp; Potassium Channel; Protein Structure; Sodium Channel; Voltage Gated Channel; Xenopus Oocyte

Simons, Michael

Research Interests:Angiogenesis; Arteriogenesis; Lymphangiogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis

Singh, Satinder Kaur

Research Interests:Chemical neurotransmission; Neuropsychiatric disease; Epilepsy; Neuropharmacology; Biogenic amine; Gamma-aminobutyric acid; Neurotransmitter transporter; Antidepressant; Structural neurobiology; X-ray crystallography; Transporter kinetics

Sklar, Jeffrey L.

Research Interests:Molecular biology of human disease, especially cancer; Molecular biologic methods of disease diagnosis; Cancer-related genes and their functions in neoplasia and normal cellular physiology; Chromosomal structure and chromosomal abnormalities in genetic and neoplastic disorders; Immunogenetics

Slayman, Clifford L.

Research Interests:Charge-dependent Transport; Proton Pumps; Potassium channels; Ribosomally Synthesized AntiMicrobial Peptides (RAMPs)

Somlo, Stefan

Research Interests:Genetic kidney and liver disease; Cilia function in tissue homeostasis; Polycystin function

Spiegel, David Adam

Research Interests:Design of novel molecules that enhance the recognition of various pathogens, including viruses, by the human immune system

Stern, David F.

Research Interests:Cancer Biology; Signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma

Suarez, Yajaira

Research Interests:Vascular Biology; Angiogenesis; Inflammation; Cholesterol homeostasis; Endothelial cells, Macrophages; Non-coding RNAs; Post-transcriptional regulation of Gene expression; MicroRNAs

Thoreen, Carson

Research Interests:Growth control; RNA; Translation; Cancer biology; Signaling; Biochemistry; Bioinformatics; Metabolism

Tomita, Susumu

Research Interests:Synaptic transmission; Brain; Biochemistry; Molecular biology; Immunocytochemistry; Gene-targeted animals; Electrophysiology

Turk, Benjamin E

Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering

Wajapeyee, Narendra

Research Interests:Genetic and epigenetic mechanisms of cancer initiation and progression

Waxman, Stephen George

Research Interests:Axons; Electrophysiology; Genes; Ion Channels; Molecular Biology; Multiple Sclerosis; Pain Syndromes; Sodium Channels; Spinal Cord Injury; Stroke

Weissman, Sherman Morton

Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics

Wu, Dianqing (Dan)

Research Interests:Wnt; signal transduction; G protein, Chemotaxis;Cell migration; Cancer biology and therapeutics; Stem cell biology; Chemoattractant signaling; Inflammation

Yan, Qin

Research Interests:Epigenetics; Gene regulation; Cancer biology; Stem cell biology

Yang, Xiaoyong

Research Interests:Nutrient Sensing; Cell Signaling; Circadian Rhythm; Post-translational Modifications; Metabolic Physiology; Diabetes; Cancer; Aging; Systems Biology

Yarbrough, Wendell

Research Interests:Head and neck oncology; Salivary oncology; Mouse modeling of human cancer; Human-in-mouse cancer models; Tumor suppressor activity; Molecular defects in cancer; NF-kappa B; NF-kB; Signaling; DNA damage; Human papilloma virus; HPV

Young, Lawrence Howard

Research Interests:Myocardial ischemia; Metabolic adaptation to hypoxic stress; Cardio-protection; Cardiomyopathy; LKB1-AMPK pathway; Diabetes

Zenisek, David

Research Interests:Physiology and cell biology of the presynaptic terminal; Retinal Bipolar Neuron; Synaptic Terminal; Synaptic Ribbons; Vesicle Transport; Exocytosis; Endocytosis

Zhou, Z. Jimmy

Research Interests:physiology and development of the mammalian retina under normal and pathological conditions; organization and function of retinal synapses and circuits; mechanisms of retinal diseases